Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Chimeric Antigen Receptors"”.
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Redirecting T Cells With Chimeric Antigen Receptors to Target Cd123+ Leukemia
… T CELLS WITH CHIMERIC ANTIGEN RECEPTORS TO TARGET CD123</strong><strong>+ </strong><strong>LE</strong><strong>U</strong><strong>K</strong><strong>E</strong><strong>M</strong><strong>I</strong><strong>A</strong></h1> <p>Radhika Thokala, Ph.D*</p> <p>Advisory …
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Engineering of next-generation chimeric antigen receptors based on alternative binding domains
Exogenous expression of chimeric antigen receptors (CARs) on T lymphocytes (CAR-T) and NK cells (CAR-NK) has allowed the design of effective therapies against lymphoproliferative diseases and has recently achieved success against solid tumors. Given their success, several researchers set out to …
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Development of 89Zirconium-PET Tracers for Immune Cell Imaging
… of genetically engineered T cells expressing chimeric antigen receptors (CAR T-cells), together with modulations of immune checkpoints have brought the rapidly advancing field of immunotherapy into a new, revolutionary spotlight with a renewed interest in cell-based therapies. In vivo imaging …
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Novel immunotherapy for paediatric cancers
Chimeric antigen receptors (CAR) are synthetic receptors that redirect T lymphocytes to specific tumour antigens. CART cells targeting CD19 (CAR19) have demonstrated remarkable efficacy against B cell malignancies in clinic. Currently used methods of CAR gene transfer to T cells based on viral …
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Engineering human single-chain T cell receptors
… associated with cancer cells, as these tumor antigens have often induced tolerance or the tumor microenvironment promotes immunosuppression of T cells. To improve the response to tumors, gene therapy with tumor specific T cell receptors provides an attractive approach to effectively arm …
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Transcription factor modulation in T-cells to improve cancer immunotherapy
Adoptive transfer of T-cells expressing chimeric antigen receptors (CAR-T) effectively treats refractory hematologic malignancies in a subset of patients, but can be limited by the inability of ex vivo culture systems to expand T-cells sufficiently for effective dosing while producing highly active …
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Engineering and characterizing human T cell receptors for cancer immunotherapies
… CDR3), which interact with the peptide (pep)MHC antigen. The conserved docking angle of the six CDRs over the pepMHC antigens is thought to confer maximal signaling capabilities and it places the two most hypervariable loops (CDR3s) over the most diverse portion of the antigen (the peptide). …
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T-Cell Treatments For Solid and Hematological Tumors
… repertoire on CD19<sup>+</sup> artificial antigen presenting cells (aAPC). Enhanced cytolysis of CD19<sup>+</sup> leukemia was observed by CAR<sup>+</sup> gamma/delta T cells compared to CAR<sup>neg</sup> gamma/delta T cells, and leukemia xenografts were significantly reduced compared to …