Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"Childhood cancers"”.
-
Lineage tracing of normal human development and childhood cancers
… analyses of tumours, mutations shared between childhood cancers and different normal tissues can shed light on the embryonic lineage of tumours and may reveal the precise juncture at which tumours began to form. Accordingly, I studied the origin of Wilms tumour, the most common childhood cancer …
-
Understanding Young Adult Survivors of Childhood Cancers’ Participation in Late Effects Screening: A Mixed Methods Approach
<p>Significant advancements in the treatment of childhood cancers have helped to increase the 5-year survival rate from 56% in the early 1970s to approximately 80-85% in the early 2000s (Greenlee, Murray, Bolden, & Wingo, 2000; Hampton, 2005). Treatment modalities such as chemotherapy and radiation …
-
Parental Factors Impacting Neurobehavioral Late Effects in Latino Pediatric Cancer Survivors
… care providers and families alike. Survivors of childhood cancers are at risk for late occurring sequelae, called late effects, which are associated with disease, chemotherapy, radiation, and surgery. Neurobehavioral late effects are some of the most debilitating late effects found, particularly …
-
Avaliação da prescrição médica na pediatria de um hospital oncológico do estado da Paraíba : elaboração de um guia farmacoterapêutico para promoção do uso racional de antineoplásicos
… occurring anywhere in the body. The most common childhood cancers are leukemias, central nervous system tumors and lymphomas. The treatment is through chemotherapy, radiation and surgery. To evaluate the medical prescriptions in pediatric an oncology hospital in the state of Paraiba, determining …
-
Patient-derived and xenograft-derived organoids for characterization, drugs testing and biobanking of pediatric brain tumors
… population and the leading cause of death among childhood cancers. They present common features related to the development and produce symptoms based on their location, rate of tumor growth and age of the child. Tumors of embryonal origin, such as medulloblastoma or primitive neuroectodermal …
-
Attitudes of Parents At Risk of Inheriting Li-Fraumeni Syndrome to wards Predictive Genetic Testing In Their Minor-Aged Children.
… predisposes individuals to cancer beginning in childhood. These risks are spread across a lifetime, from early childhood to adulthood. Mutations in the p53 tumor suppressor gene are known to cause the majority of cases of LFS. The risk for early onset cancer in individuals with Li-Fraumeni …
-
Cancer incidence by Ethnic Group in England, 2001-2007
… unexplained variations in the incidence of many cancers globally and the incidence of cancer in migrant populations can contribute to our understanding of aetiology for cancers for which there are few established risk factors. Studying different ethnic groups in the same country overcomes the …
-
Characterizing the Activity of Three Novel Differentiation-Inducing Compounds in Neuroblastoma Cells
… tumor in children. It makes up 8% of all childhood cancers and is the cause of 15% of all childhood cancer-related deaths. Neuroblastoma arises from neural crest precursor cells that fail to differentiate into mature neurons. The biggest threat for high-risk neuroblastoma patients is …
-
Incorporating range uncertainty into proton therapy treatment planning
… considered to be advantageous in treating most childhood cancers and certain adult cancers, including those of the skull base, spine and head and neck. Protons, unlike X-rays, have a finite range highly dependent on the electron density of the material they are traversing, resulting in a steep …
-
Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse
… rare cancer that accounts for only 0.5-2% if all childhood cancer cases, HB has the largest increase in incidence among childhood cancers in the United States and worldwide. The five-year survival rate of children with the aggressive forms of HB, including those that have developed metastatic or …
-
Paediatric brain tumours: The University of Cape Town experience from 1996 - 2017
… in general remain poor when compared with other childhood cancers. Optimal treatment of children with brain tumours is challenging and expertise and resources are not widely available in South Africa. This is important because the outcomes of children with brain tumours depend critically on the …
-
The Role of Cell Sterilization In Population Based Studies of Radiogenic Second Cancers Following Radiation Therapy
… of their sensitivity to radiation induced second cancers. However, due to the rarity of childhood cancers and the long latency of second cancers, large sample sizes are unavailable for the epidemiological study of contemporary radiotherapy treatments. Additionally, when specific treatments are …
-
Transcriptional consequences of genetic variation on single cells in development and cancer
… data. CNVs, frequently observed in human cancers, can serve as markers to track the development of cancer and subclones. By integrating the information from whole genome sequencing (WGS) data, alleleIntegrator definitively genotypes individual transcriptomes by assessing allelic imbalances …