Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Chemotherapeutic treatments"”.
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Exercise mitigates chemotherapy-induced cognitive impairment in a mouse model of breast cancer.
… cancer survivors. While many commonly used chemotherapeutic treatments do not cross the blood-brain-barrier they do suppress cell proliferation which has been associated with the suppression of hippocampal neurogenesis. Previous studies have demonstrated that cancer likely plays into the …
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Bacteria-Enabled Autonomous Drug Delivery Systems: Design, Modeling, and Characterization of Transport and Sensing
The lack of efficacy of existing chemotherapeutic treatments of solid tumors is partially attributed to the limited diffusion distance of therapeutics and the low selectivity of anti-cancer drugs with respect to cancerous tissue, which also leads to high levels of systemic toxicity in patients. …
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Mathematical Modelling of Cancer Growth and Development: Adhesion, Stem Cells and Structure
… in a solid tumour can affect the efficacy of chemotherapeutic treatments.
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Analysis Of The Effects Of Metformin Administered Alone Or In Combined Treatments In Colorectal Cancer
… antagonised their effects in the majority of the treatments. On the contrary, its administration after long chemotherapeutic treatments significantly reduced the cell viability. I noted that metformin better inhibits cell proliferation in cell lines with rapid growth. I have also assessed the dual …
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Immune Cell Subsets Direct or Antagonize Tumor Immunity: Promotion of TH1 Responses in Tumor Vaccination
… production by splenic CD4+ T cells. Since chemotherapeutic treatments have potent cytostatic effects, we posited they enhance T cell dysfunctionality; which leads to limited therapeutic efficacy. Paclitaxel is a potent chemotherapeutic agent currently being administered in Stage III …
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The role of CCR7 axis in facilitating chemoresistance, radioresistance and induction of cell proliferation in cancer
… factors, in particular that caused by different chemotherapeutic treatments. In addition, we showed that CCL21, one of the two endogenous ligands for CCR7 is similarly produced under these conditions We used several techniques to establish the expression and functionality of CCR7 and CXCR4 in …
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The Protumorigenic Role of Caspase-8 in Neuroblastoma
… from cell death mediated by either integrins or chemotherapeutics. Paradoxically, casp8 expression is maintained in 30-50% of NB patient samples giving rise to the possibility that casp8 may provide selective advantages for NB tumorigenesis. Caspase-8 is shown to increase tumor cell adhesion, …
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Growth Factors Up-Regulate Epithelial Stem Cells: Treatment Strategies for Colorectal Cancers
… that CSCs are resistant to radiation and chemotherapeutic treatments, and are the likely cause of cancer relapse. It is therefore important to develop novel therapies which are relatively non-toxic and specifically target CSCs. Therefore the fourth goal was to examine the inhibitory …
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A histone H4 code regulates 53BP1-mediated responses to DNA damage
… cancer, and interruption of the DDR is used in chemotherapeutic treatments against cancer. Further investigation of the role of H4 modifications in DDR will enhance our understanding of how genome integrity is maintained in normal cells and may provide insights crucial for developing new cancer …
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Understanding cell fate decisions in response to 0⁶-Methylguanine DNA lesions
… agents comprise a major class of DNA damaging chemotherapeutics. The 0⁶MeG DNA lesion is a highly mutagenic, carcinogenic, and cytotoxic lesion produced by SNl methylating agents. Additionally, persistent 0⁶MeG lesions induce apoptosis in an 0⁶MeG DNA methyltransferase (MGMT) repair- and …
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The in vitro delivery of Doxorubicin using biosynthesized versus chemically synthesized stealth site-specific Bimetallic Selenium-silver nanoparticles
Submitted in partial fulfillment for the Master of Applied Science (Biotechnology), Durban University of Technology, Durban, South Africa, 2022.
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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
… lipophilic agents, of importance, MDR1 effluxes chemotherapeutics agents out of the cell resulting in a low and ineffective intracellular drug concentration. Thus, the over production of MDR1 in cancer cells can then be thought of as a protective factor for cancer cells, and as an effect causes …
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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
… lipophilic agents, of importance, MDR1 effluxes chemotherapeutics agents out of the cell resulting in a low and ineffective intracellular drug concentration. Thus, the over production of MDR1 in cancer cells can then be thought of as a protective factor for cancer cells, and as an effect causes …
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Potential of bacteriocin producing bacteria to control VRE infection
… faecalis is discussed. Also discussed are the chemotherapeutic treatments currently in use in treatment of VRE infections. Finally, a number of novel alternatives to antibiotics such as bacteriocins and bacteriophage and their efficiency are evaluated. In Chapter 2, the ability of Avicin, a …