Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 99 for “"Chemotherapeutic drugs"”.
-
Apoptosis induced by cancer chemotherapeutic drugs and its genetic suppression
… apoptotic cell death on treatment with chemotherapeutic agents in an IL-3 dependent cell line (FDCP-1) and three different EBV genome-positive Burkitt's lymphoma cell lines, the survival of EBV-BL cell lines expressing either exogenous bcl-2 or BHRF1 was examined. Suppression of …
-
Chemotherapeutic drugs, 5-fluorouracil and cisplatin, differentially affect exprssion of drug metabolising enzyme genes in an oesophageal cancer cell line
… to a variety of other compounds that along with chemotherapeutic drugs may alter DME gene expression. Changes in DME gene expression influence the therapeutic outcomes for patients; thus, understanding the effects of drugs and compounds on the expression of DMEs is crucial for the advancement of …
-
E2F1 induction following DNA damage and oncogene activation
… drug induced death. E2F1 is induced by various chemotherapeutic drugs and this induction, in addition with oncogenic stress, contributes to increased chemosensitivity. Cells expressing the adenovirus early region 1A (E1A) oncogene have been used as a tool to identify cellular regulatory pathways …
-
Stabilization of Topoisomerase 2 Mutants Initiates the Formation of Duplications in DNA
… genome integrity. Top2cc stabilization by chemotherapeutic drugs such as etoposide leads to persistent and potentially toxic DSBs. This thesis characterizes two novel top2 mutants, both of which are associated with a mutation signature characterized by de novo duplications. These …
-
Mathematical Models of Chemotherapy
… the cancer and normal tissue, cell specific chemotherapeutic drug, the use of non-constant parameters to aid in modeling specific chemotherapeutic processes, and drug resistance. By studying the models we can obtain a better understanding of the dynamics of the chemotherapeutic drugs and how …
-
Impairment in mitochondrial oxidative phosphorylation alters clock gene expression
… oxygen species (ROS) in cells exposed to chemotherapeutic drugs. Melatonin influenced the cell cycle but did not cause significant differences in clock gene expression. Chemotherapeutic drugs differed in their effects on the production of intracellular ROS. A mitochondrial deficient (Rhø) …
-
Molecular mechanisms of drug resistance, invasion and metastasis in pancreatic carcinoma
… at an early stage and is refractory to most chemotherapeutic drugs. Investigation into drug resistance in pancreatic cancer involved pulse-selection of three cell lines with epirubicin, taxotere and gemcitabine. The drug-selected cell lines, in general, displayed low changes in sensitivity to …
-
A histological and immunological response study of an implantable microcapsule drug delivery device for the treatment of glioblastoma
… due to systemic toxicity associated with many chemotherapeutic drugs. Advances in implantable drug delivery devices look promising, but can suffer from the possibility of biofouling, or loss of function due to a patient's own immune response. An implantable microcapsule device, designed to …
-
Synthesis and biological activity of ajoenes with increased aqueous solubility
… shown to enhance the apoptotic effects of two chemotherapeutic drugs Doxorubicin and Vincristine via chemosensitization. This effect was attributed to the presence of at least one p-methoxybenzyl substituent in the structure.
-
Assessment of the in vitro efficacy of aspirin and aspirin analogues in combination with standard chemotherapeutics in glioma cell lines
… patients. Aspirin, one of the most commonly used drugs reduces the viability and proliferation of glioblastoma both in vitro and in vivo. This study examined the combination of aspirin or its analogue PN517 with the standard chemotherapeutic (cisplatin) and determined effects on cell viability, …
-
Toll-Like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice
… treatment limiting efficacy of DNA-damaging chemotherapeutic drugs. The Toll-like receptor 5 (TLR5) agonist, Entolimod, has demonstrated efficacy in mitigating damage to hematopoietic (HP) and gastrointestinal (GI) tissues caused by radiation. Here, using 5-Fluorouracil (5-FU) treated mice as …
-
DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL INDENOISOQUINOLINES AS POTENTIAL ANTICANCER AGENTS
… present, there are only two FDA-approved cancer chemotherapeutic drugs that target this enzyme. These agents bind to a covalent Top1-DNA cleavage complex intermediate that is formed when Top1 relaxes supercoiled DNA. The effect of this stabilization is that a DNA replication fork can “collide” …
-
Design and evaluation of drug loaded microbubbles for ultrasound guided cancer therapy
… are able to carry genetic (pDNA, siRNA) and chemotherapeutic (doxorubicin) drugs. We proved that these microbubbles can selectively deliver their genetic or chemotherapeutic drugs to melanoma cells upon ultrasound exposure. We also showed that the activity of currently available drug carriers …
-
Opto-Electronic Modulation of Quantum Dots by Cells and Bioactive Molecules
… dispersions due to bioactive molecules in common chemotherapeutic drugs and due to reactive oxygen species (ROS) produced by these cells (HL60, K562) following chemotherapy and radiotherapy. This optical modulation constitutes what we describe as opto-electronic modulation. This type of tuning …
-
Proline-rich acidic protein 1 in Life and Death
… significantly enhances the anti-tumor effect of chemotherapeutic drugs used in the treatment of CRC. This is partly mediated through the abrogation of S-phase arrest in a p53 dependent manner, resulting in increased DNA damage and activation of the apoptotic pathway over cell cycle arrest. PRAP …
-
The role of tunneling nanotubes in mediating intercellular communication in cancer
… heterogeneity, tumor metastasis, resistance to chemotherapeutic drugs, and the ability of TNT-mediated communication in conditions such as hypoxia that are typical of the tumor microenvironment. If intercellular communication via TNTs proves to be critical to tumor invasion and the development …
-
Development of microfluidic devices to maintain and interrogate tissue biopsies - biomedical applications
… interrogation by several apoptosis inducing and chemotherapeutic agents. Liver tissue samples were also disaggregated in situ on-chip into individual primary cells, using a collagenase digestion procedure, enabling further cell analysis to be carried out off-line. Cancer tissue was probed with …
-
Celastrol induces paraptosis-like cell death via mitochondrial Ca2+ overload in breast cancer cells
Various cancer cells are resistant to chemotherapeutic drugs-induced apoptosis. Thus, cancer cells that have acquired resistance to apoptosis need novel strategies for inducing non-apoptotic cell death. Paraptosis is a kind of non-apoptotic cell death and characterized by extensive vacuolization …
-
An investigation on role of the ATP-binding cassette B5 (ABCB5) transporter as potential mediator of melanoma resistance to BRAF inhibition
… types. These transporters expel the anti-cancer drugs out of the cell, thereby decreasing the intracellular concentration of the drug. In melanoma, the ATP-binding cassette B5 transporter (a member of ABC superfamily) has been linked to chemoresistance by drug extrusion. Moreover, overexpression …
Page 1 of 5