Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"Chemotherapeutic agent"”.
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Evaluation of ceftiofur sodium as a chemotherapeutic agent in grass carp (Ctenopharyngodon idella)
… drug as an alternative bacterial therapeutic agent for the aquaculture and ornamental fish industry. Grass carp, Ctenopharyngodon idella have been selected as the fish model for this study since they are a good representative for both foodfish and ornamental fish and are one of the major …
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Development of a Canine Coccidiosis Model and the Anticoccidial Effects of a New Chemotherapeutic Agent
… to determine the efficacy of a new anticoccidial agent. A canine coccidiosis model would be useful in evaluating new anticoccidial treatments. Oral infections with 5 X 104 (n=2) and 1 X 105 (n=20) sporulated C. canis oocysts were attempted in 22 purpose bred beagle puppies. Clinical signs …
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Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort
… after curative surgical resection. The main chemotherapeutic agent is 5-Fluoroucacil (5-FU). Studies have attempted to elucidate whether the MMR status of a colorectal cancer (CRC) cohort will define a response to 5-FU therapy. However, no difference in long term response or survival after …
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Methodological Innovations in Polyketide Synthesis and their Application toward the Scalable Synthesis of Anti-Tumor Agent Spongistatin 1
… a scalable synthetic route to access anti-tumor agent spongistatin 1, or analogs thereof. In an effort to achieve this goal, several new chemical reaction platforms were established. Though these novel chemical transformations were developed specifically for use in the total synthesis of …
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The development and characterisation of MicroRNA and gemcitabine nanotherapies for the treatment of pancreatic cancer
… genes. The utilization of miRNAs as therapeutic agents has showed promising rapid progress in the last 10 years but are limited because of the lack of appropriate delivery systems that will ensure reach of the pharmacological targets. On the other hand, the bottleneck with using gemcitabine, the …
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The Influence of Certain Lytic Agents on the Oxygen Consumption of Dog Erythrocytes
… war (3). Investigation of methylene blue as a chemotherapeutic agent again revealed its hemolytic action. Mice were successfully treated with the dye for Tsutsugamushi disease but subsequently developed anemia (4).
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FLUOXETINE AS A NOVEL TREATMENT TO ATTENUATE CISPLATIN-INDUCED COGNITIVE IMPAIRMENT
<p>Cisplatin, a chemotherapeutic agent, initiates cell death through various methods that include mtDNA damage during cell replication and produces damaging pro-inflammatory cytokines. This can result in long-term chemotherapy-related cognitive impairment (CRCI). Fluoxetine (FLX) is a selective …
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Preparation and characterization of multifunctional chitosan microparticles for lung delivery
… approach with an aim of utilizing both chemotherapeutic agent as well as radio frequency (RF) heating for targeted lung cancer therapy. The system designed for achieving this was a chitosan microparticulate system containing iron oxide nanoparticles and gemcitabine as the …
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A MOLECULAR ORBITAL STUDY OF 5-FLUOROURACIL AND RELATED COMPOUNDS
<p>5-fluorouracil is a chemotherapeutic agent which is used in the treatment of disseminated colon and breast cancers. As an antimetabolite it has been found to inhibit the mechanism in which the normal substrate reacts with the enzyme and a cofactor in nucleic acid synthesis. A number of …
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In vivo activation and biocompatibility of a MEMS microreservoir drug delivery device
… molecules (fluorescein and mannitol) and a chemotherapeutic agent (carmustine) in rats. Both temporal and spatial profiles of the tracer molecules were established; only the temporal kinetics of the carmustine were studied. The MEMS drug delivery device is based on a silicon substrate into …
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A Model for Studying Vasogenic Brain Edema
… states. This is of importance when dealing with chemotherapeutic agent delivery to brain tumors, where vasogenic edema (VE) exists. The current study aims to characterize a model of VE suitable for studying CED.VE was produced in the right hemisphere of the rat brain using multiple infusions of …
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Investigating the effects of EZH2 inhibitors on targeting epigenetic changes in head and neck squamous cell carcinoma
… HPV oncogenes E6 and E7 are the main causative agents for cancer progression in HPV positive HNSCC, due to their interactions with tumour suppressor proteins P53 and Rb and the HPV oncogene’s ability to inactivate them. Similarly, in HPV negative HNSCC mutations in the p53 and Rb tumour …
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Novel Small Molecule Induces Apoptosis in Malignant Peripheral Nerve Sheath Tumors of Neurofibromatosis Type I
… as therapy, but this DNA-intercalating agent has relatively low tumor specificity and limited efficacy. In this study, we exploited a robust genetically-engineered mouse model of MPNST that recapitulates human NF1 associated MPNST to identify a novel small chemical compound that inhibits …
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THE STUDY OF CD24 AS A PREDICTIVE INDICATOR IN CISPLATIN TREATMENT RESPONSE OF HEAD AND NECK CANCER
Platinum-based therapy is the most often used chemotherapeutic agent to treat advanced cases of head and neck cancers. However, only a small fraction of the patient population responds to cisplatin, with a median survival time of less than a year. Currently, there is a lack of clinically employable …
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Design, Synthesis and Biological Evaluation of Novel Estradiol-Triazole Analogs Targeting Epidermal Growth Factor Receptors in Colorectal Cancer
… ranging from 3.5 μM to 30 μM in comparison to a chemotherapeutic agent 5- flurouracil (5-FU) (IC50 17.3 μM) which is a standard drug for CRC.</p>
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Mechanical characterization and in vivo operation of an implantable drug delivery MEMS device
… of tracer molecules as well as a radiolabled chemotherapeutic agent (carmustine, or BCNU) from the device. However, systematic characterization of the mechanical and electrochemical behavior of gold membranes on the drug delivery device was necessary in order to achieve more reliable device …
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EVALUATING THE EFFECTS OF FASTING CONDITIONS IN COMBINATION WITH TEMOZOLOMIDE FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME
… followed by adjuvant treatment with the chemotherapeutic agent temozolomide (TMZ) and radiotherapy. O-6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein involved in TMZ resistance. Known as the Warburg effect, cancer cells will preferentially oxidize glucose to lactate …
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Immune Cell Subsets Direct or Antagonize Tumor Immunity: Promotion of TH1 Responses in Tumor Vaccination
… production by splenic CD4+ T cells. Since chemotherapeutic treatments have potent cytostatic effects, we posited they enhance T cell dysfunctionality; which leads to limited therapeutic efficacy. Paclitaxel is a potent chemotherapeutic agent currently being administered in Stage III …
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Paclitaxel-induced macrophage activities in the tumor-bearing host: immunologic implications and therapeutic applications
… activities. Because the antineoplastic agent paclitaxel (TAXOL) activates Mf function, we studied mechanisms of paclitaxel-mediated cytotoxic and immunostimulatory responses by tumor-induced Mfs. Although tumor-derived factors, including interleukin-10 and transforming growth factor-b1, …
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Induction of Immunogenic Cell Death via Nanoparticle-Mediated Dual Chemotherapy and Photothermal Therapy
… Both NPs were loaded with doxorubicin, a chemotherapeutic agent, and indocyanine green, a PTT agent that can absorb the light in near infrared (NIR) region and convert it to heat. NPs were characterized and confirmed to be suitable for agent delivery. Both types of NPs were shown to …
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