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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 204 for “"Chemotherapeutic Agents"”.
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Novel chemotherapeutic agents for oesophageal cancer
Chemotherapeutic agents such as cisplatin, doxorubicin and 5-fluorouracil are currently used in the treatment of a variety of cancers, including oesophageal cancer. Although these agents have been part of our therapeutic repertoire for many years, there are several side effects that have been …
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Some potential chemotherapeutic agents derived from aralkyl ketones
Dissertation (Ph.D.)--University of Kansas, Pharmaceutical Chemistry, 1952.
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Responses of Nitrifying Bacteria to Aquaculture Chemotherapeutic Agents
As in any animal production industry, disease is inevitable; therefore, it is imperative that aquaculturists are able to effectively manage the disease and maintain their high production levels in an effort to bridge the gap between supply and demand in the seafood industry that has been caused in …
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USE OF DNA APTAMERS FOR TARGETED DELIVERY OF CHEMOTHERAPEUTIC AGENTS
The development of safe and efficacious chemotherapeutics has been the goal of cancer researchers for decades. Many different methods have been used to pursue this goal ranging from small molecules that act targets to large biomolecules such as antibodies. Aptamers are a new class of biomolecules …
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The synthesis, structural characterization and biological evaluation of potential chemotherapeutic agents
… them potential targets at which to direct novel chemotherapeutic agents. The inhibitor N-benzoyl-L-Leu-Gly nitrile prepared in this laboratory was shown to possess significantly greater inhibitory potency on the liver fluke Fasciola hepatica cysteine cathepsin L like endoproteases over the known …
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Application of pharmaceutical technologies to improve the activity of cancer chemotherapeutic agents
… modality in cancer treatment. Conventional chemotherapeutic agents usually have limited efficacy. Furthermore, chemotherapeutic agent- and/or excipient-related toxicities comprise a serious problem that may, in many cases, deteriorate the patient’s quality of life. In this dissertation, …
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NATURAL OR BIO-INSPIRED POLYPHENOLS IN THE SYNTHESIS OF POTENTIAL CHEMOTHERAPEUTIC AGENTS
… compounds and to their evaluation as potential chemotherapeutic agents. More specifically, my research activity was devoted to lignans and neolignans, synthetized by chemical and/or enzimatic methodology. Hence, in particular, two polyphenol groups were studied, namely benzoxanthene lignans, …
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Development of Core-Shell Polymeric Nanostructures for Delivery of Diagnostic and Chemotherapeutic Agents
Macromolecular complexes of anionic-nonionic block copolymers and cationic antibiotic aminoglycosides have been formed by electrostatic condensation. Amphiphilicity of the complexes was introduced into the shells by incorporating a hydrophobic poly(propylene oxide) segment into the block copolymer. …
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The Effect of Some Chemotherapeutic Agents on The Blood and Bone Marrow of Chickens
Made available in DSpace on 2015-05-12T17:14:36Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 0018194.PDF: 4181260 bytes, checksum: 91c7e57fb98d2fed7ef5bee95a2e56d3 (MD5) Previous issue date: 1956
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The Effect of Some Chemotherapeutic Agents on The Blood and Bone Marrow of Chickens
Made available in DSpace on 2014-12-05T23:14:06Z (GMT). No. of bitstreams: 1 0018194.pdf: 4181260 bytes, checksum: 91c7e57fb98d2fed7ef5bee95a2e56d3 (MD5) Previous issue date: 1956
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Intracellular Transport in Cancer Treatments: Carbon Nanohorns Conjugated to Quantum Dots and Chemotherapeutic Agents
… cellular barriers to transport. Nanoparticle or chemotherapeutic compound intracellular transport has implications in understanding therapeutic effect and toxicity. The scope of this thesis was to study the intracellular transport of carbon nanohorns and to improve the efficacy of various …
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Developing New Chemotherapeutic Agents Against Bone Resorption and Parasitic Diseases Through Computer -Aided Drug Design
Using the above mentioned 3D-QSAR methods we have developed predictive models of the inhibition of human farnesyl pyrophosphate synthase (FPPS), important for osteoclast function and survival as well as Trypanosoma brucei FPPS, soluble vacuolar pyrophosphatase and phosphoglycerate kinase, all …
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Studies of DNA lesion-protein interactions : toward the development of DNA repair-inhibiting chemotherapeutic agents
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1996.
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Design and synthesis of modified deoxynucleosides, site specifically damaged oligonucleotides, and repair inhibiting chemotherapeutic agents
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.
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In Vivo Interaction Between Health Food Supplements and Chemotherapeutic Agents on DNA Damage and Cell Production
… DNA and cause cell damage and can interact with chemotherapeutic agents, and that flow cytometric analysis is a rapid and reliable technique for screening the cytotoxic and genotoxic effects of these products.
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Rational Design of Chemotherapeutic Agents by Quantitative Structure-Activity Relationships and Solution NMR Methods for High Resolution Protein Structure Refinement
Second, work towards the study of solution protein structure refinement methods by high-resolution multi-dimensional nuclear magnetic resonance (NMR) spectroscopy is discussed. Uniformly 13C, 15N-labeled Saccharomyces cerevisiae iso-1 cytochrome c was overexpressed in Escherichia coli and purified …
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Establishing a Mouse Model of Glioblastoma (GBM) And Developing Strategies to Eliminate Cancer Cells.
… demand. Among the widely used anti-metabolites (Chemotherapeutic agents, CAs), each compound approved for human use by the Food and Drug Administration (FDA) has side effects. Three main phenomena contribute to the side effects and the reappearance of cancer: (a) the cancer cells become resistant …
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Targeted and stimuli-responsive polymers as chemotherapeutic delivery systems
Successful administration of chemotherapeutic agents for cancer treatment requires a balance between the efficacy and the safety of the drug. This often limits physicians to a very narrow therapeutic window. To avoid the harmful side-effects, chemotherapeutic agents may be administered at a …
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Evaluation of Peptides and Peptide–Doxorubicin Conjugates Designed and Synthesized for Targeting Triple-Negative Breast Cancer via Cell-Surface Receptors
… problem faced in oncology is the lack of chemotherapeutic agents that are tumor site-specific, resulting in reduced therapeutic efficacy and unintended infliction of harm to surrounding healthy tissues and cells that often lead to serious side effects. Current strategies being explored to …
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