Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Chemosensitizer"”.
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Synthesis and bioactivities of novel N¹-acylhydrazides
… The combinatorial study indicated that 60m is a chemosensitizer towards HCT 116 cells to 3,5-bis(benzylidene)-4-piperidone 63a and the reference drug 5-fluorouracil (Table 5.8, 6.2). When screened against various human oral carcinoma and normal cell lines, 63a has shown potent cytotoxicity (CC50 …
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Nuclear Factor Kappa B Pathway and human cancer therapeutics
… study was involved in using NF-κB inhibitor as a chemosensitizer to sentizise the anti-cancer drug-induced chemoresistance cells to anti-cancer drugs. The results derived from this study manifested that the anti-alcoholism drug, Disulfiram (DS), and anti-inflammatory drug, triptolide (PG490), …
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Structural and Inhibitor Binding Studies of Tyrosyl-DNA Phosphodiesterase 1
… agents in cancer cells. In addition to being a chemosensitizer target, a histidine to arginine (H493R) mutation in human TDP1 has also been shown to cause a neurodegenerative disease called spinocerebellar ataxia with axonal neuropathy (SCAN1). There are current efforts to develop activators as …
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The Membrane as a barrier or target in cancer chemotherapy
… generation of singlet oxygen. Addition of the chemosensitizer, verapamil (7gM), increased the efficacy of doxorubicin by 2-fold in EMT6-S cells and by 18-fold in EMT6-R cells. By contrast, the presence of verapamil did not increase the cytotoxicity of YBBO in either cell line. A series of …
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Clinical pharmacokinetics of low dose paclitaxel in Asian patients with nasopharyngeal carcinoma
The pharmacokinetics (PK) of low-dose paclitaxel in Asian patients with WHO Stage III nasopharyngeal carcinoma treated with a chemo-radiation regimen were determined and correlated with subjecta??s demographics, clinical parameters, outcome with the intent of optimizing therapeutic benefit to risk …