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Showing 1 to 20 of 86 for “"Chemoselective"”.
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Chemoselective Oxidation of 6,13-Bis(decylthio) Pentacene
… research was performed to chemically control the chemoselective oxidation of the compound 6,13-5/s(decylthio)pentacene to produce a new pentacene derivative bearing either sulfoxide or sulfone functional groups thus forming a new pentacene derivative which may show greater photoxidative …
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Exploiting activated esters in novel chemoselective amide formation reactions
… includes the application of activated esters in chemoselective amide formation reactions. The introduction summarizes the significance and use of activating agents in lipase catalysed reactions over the classical methods of amides synthesis. Additionally, a detailed review on some currently …
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Radical reactions for chemoselective modification of peptides / by Caroline Mary Ward.
… with a view to developing procedures for chemoselective modification of peptides and proteins. Trapping and detection of these radicals has also been studied.
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Development and investigation of novel chemoselective processes in Pd and Cu catalysis
The development of chemoselective processes is of utmost importance for the future of synthetic organic chemistry, and has been described as 'the single greatest obstacle to complex molecule synthesis'. Chemoselectivity is required to exploit the full potential of synthetic developments in organic …
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Transition metal-catalyzed olefin functionalization for highly regio-, enantio-, and chemoselective C–X bond formation
The development of alkene functionalizations is an important challenge in modern catalysis.1 This thesis specifically focuses on using transition metal-catalysis to form C–X bonds from C–C double bonds with high degrees of regio-, chemo-, and stereoselectivity. In chapter 1, a regiodivergent …
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Developing New Methodologies for Crosslinked Polymeric Nanostructure Syntheses, Chemoselective Modifications, and Applications as Imaging and Delivery Agents
… with fluorescent molecules through chemoselectively-reductive amination and were shown to display interesting in vitro cell association behaviors. The micelles were modified with near-infrared fluorescent dyes and crosslinked with diamino crosslinkers, each via reductive amination, …
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A base modulated synthesis of indoles and quinolines, an expedient synthesis of salviadione, and chemoselective couplings en route to indoles and pyrroloindoles
Palladium-catalyzed reductive N-heteroannulation of ortho-nitrostyrenes has become a synthetically useful method for the construction of indoles and indole-based heterocycles. Soderberg's elaboration of this methodology has been utilized in the synthesis of indoles and quinolines from a common …
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Chemoselective and Stereoselective Exploration of the Chemical Reactivity Space of Castagnoli-Cushman-Derived Allylic Lactamoyl Esters: Application to the Synthesis of Aza-Polycyclic Architectures
The synthesis and evaluation of structure-activity relationships of saturated nitrogen heterocycles is the focal point of various pharmaceutical companies thanks to the high biological activity of previously isolated azacycles. Here, we describe an operationally simple and highly efficient approach …
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I. Chemoselective Dehydrative Glycosylation With Application Toward Oligosaccharide Synthesis. II. Sulfide-Mediated Direct Glycosylation of C(1)-Hydroxyl Glycosyl Donors. III. Studies Toward the Total Synthesis of Auriside A
Our efforts for the development of novel strategies for the total synthesis of auriside A are present in the third part of the dissertation. The hemiacetal disaccharide portion of auriside A is successfully synthesized. The convergent synthesis of the auriside aglycon component is accomplished in …
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Phosphate Tether-Mediated, One-Pot Metathesis Processes: Application in Small Molecule Synthesis
… to this molecule invokes cross-metathesis, chemoselective hydrogenation, regio- and diastereoselective cuprate addition and Mitsunobu esterification as key synthetic transformations. Additionally, a phosphorodiamidite coupling and one-pot, sequential RCM/CM/chemoselective hydrogenation …
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Metal-Catalyzed Formation and Transformations of Carbon-Boron Bonds
… of the sp2 and the sp3 C-B bonds can allow for chemoselective transformations. However, oxidation of the carbon-boron bond is one example in which the conditions are unselective. To address this shortcoming, a platinum catalyst was developed for the diboration of 1,1-diaryl allenes with a …
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Enantioselective epoxidation catalyzed by manganese-substituted human carbonic anhydrase
… for enantioselective, regioselective and chemoselective organic transformations. Despite several limitations associated with this type of hybrid catalysts system and their limited development relative to small molecule catalysts, significant advances have been achieved over the past few …
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Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents
… The synthesis involved a radical addition and a chemoselective oxidation as key steps. Characterisation was carried out by [1]H NMR, [13]C NMR, IR and HRMS spectroscopies.
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Dechalcogenative Allylic Selenosulfide And Disulfide Rearrangements For Cysteine Modification And Glycoligation
… <p>Chapter one introduces the concept of chemoselective ligations for the modification of macromolecules like carbohydrates and proteins. It overviews the native and non-native ligation techniques for their modification of such entities with a attention focusing on thiol based ligation …
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Applications of Cobaloxime/Photoredox Co-operative Catalysis Toward Olefin Functionalization
… has been to devise strategies that allow for the chemoselective cross-coupling of olefins with a variety of versatile functional groups toward the synthesis of synthetically valuable building-blocks, whilst simultaneously adhering to the principles of green chemistry. This has been achieved …
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Preparation of Dehydropeptides and Their Application in the Convergent Synthesis of Peptide Conjugates
… into peptides will provide a handle for the chemoselective incorporation of nucleophiles. Based on this analysis, a convergent route involving site-specific modification of the unprotected dehydropeptide (the electrophilic handle) by Michael additions of suitable nucleophiles was developed. …
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Organic reactions catalyzed by copper(I) hydride complexes
… Allylation of Imines with Terminal Allenes A chemoselective hydrometalation process enables the use of easily accessible allenes as allylmetal nucleophile surrogates in imine allylation reactions. By modulating the nitrogen-protecting group, either highly branched- or linear-selective addition …
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Chemical Biology Tools to Study Bacterial Cell Surface Glycans
… other biomacromolecules, which often exploit chemoselective reactions for covalent modification, capture, or imaging. Unlike the amino acid residues that constitute proteins, glycan building blocks are composed primarily of polyol isomers and lack distinguishing reactivity required for …
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Charge-Transfer Complexes for Amine Synthesis
… and hydrogen atom source. Subsequently, the chemoselective reductive amination of secondary amines over primary amines was attempted. Preliminary studies on a di-amine drug indicated that the radical reductive amination had high selectivity for primary aminothiazoles over secondary amines, …
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Synthesis and anti-HIV activity of [d4U]-spacer-[HI-236] bifinctional HIV-1 reverse transcriptase inhibitors
… The synthesissurmounted several challenges, with chemoselective distinction of unsaturation vialate introduction of the d4U double bond using Corey-Winter methodology as thehighlight.
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