Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 150 for “"Chemoresistance"”.
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The mechanism of ovarian cancer chemoresistance
… as the PI3K/Akt/mTOR signalling pathway in OC chemoresistance, and provides a range of potential candidate chemoresistant biomarkers with proteomic technologies. The aims of this study were to: 1) compare the expression differences of EMT, CSC and PI3K/Akt/mTOR pathway related biomarkers …
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Characterising pathways driving aggressive biology and chemoresistance in triple negative breast cancers biology and chemoresistance in triple negative breast cancers
… served to investigate the mechanisms driving chemoresistance in a series of in vitro TNBC cell line models. Molecular characterisation and comparison of drug resistant models allowed for the identification of promising druggable targets, whose efficacy in restoring chemosensitivity was …
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Inhibition of the autophagy pathway modulates osteosarcoma chemoresistance
… the survival rate of osteosarcoma patients, chemoresistance remains a major clinical problem underlying poor survival outcome. Previous studies have shown that deregulation of a cell survival process called autophagy is closely associated with this phenomenon. This study aims to further …
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Contribution of LEDGF/p75 to Prostate Cancer Chemoresistance
<p>Prostate cancer (PCa) is the second leading cause of male cancer death in the United States, and is considered a health disparity because of its disproportionate incidence and mortality in African American (AA) males. A major challenge in PCa treatment is its recurrence into hormone refractory …
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Mechanisms of microenvironmental paracrine signaling in cancer chemoresistance
Chemoresistance remains a major barrier to the effective treatment of cancer. Cancer therapy occurs in the context of a tissue environment, with cancer cells surrounded by many non-malignant cells that contribute to tumor growth and resistance to therapy. Yet much remains unknown about the tumor …
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NON-GENETIC MECHANISMS OF CHEMORESISTANCE IN ACUTE MYELOID LEUKEMIA
… stem cells. My working hypothesis is that chemoresistance in AMLs is associated with specific phenotypic states that characterize rare cell populations found within the pool of quiescent leukemic cells. These cells are selected by chemotherapy and represent the cellular basis of the …
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Cancer Cell Mechanics in Chemoresistance and Chemotherapeutic Drug Exposure
… due to treatment failure or the development of chemoresistance. The concept of chemoresistance however is complex, recent studies have highlighted that cellular structure and extra-cellular composition, mechanics and structure play a role in the development of chemoresistance. The mechanical …
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CELLULAR AND MOLECULAR MECHANISMS OF CHEMORESISTANCE IN ACUTE MYELOID LEUKEMIA
… to the development of chemotherapy resistance. Chemoresistance is the cause of death for over 90% of AML patients. The mechanisms underlying chemoresistance in AML are not yet fully understood, and targeted therapies aimed at preventing chemoresistance are not currently available. …
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ROR1 and Rab27b – novel biomarkers for chemoresistance in ovarian cancer
… to investigate ROR1 and Rab27b as biomarkers for chemoresistance in ovarian cancer. Ovarian cancer cell line panel was assembled comprising of; HEY, SKOV-3, OVCAR-3 and OAW42. The IC50 doses of four drugs; cisplatin, carboplatin, taxol and talazoparib for the cell lines were determined. qPCR was …
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Evaluation of the role of autophagy in ovarian cancer chemoresistance
… for canonical and non-canonical autophagy in OC chemoresistance, and demonstrated for the first time a potential role for nucleophagy in OC cell recovery. It is hoped that autophagy inhibitors, along with appropriate biomarkers, may be incorporated into treatment strategies to overcome treatment …
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Involvement of CD133+ stem cells in the chemoresistance of glioma
… CD133+ cells in SFM. To establish a link between chemoresistance and cancer stem cells, the glioma cell lines were treated with commercially available anti-cancer drugs at various concentrations and their chemosensitivity was compared in SFM and SCM. The U87MG cells when treated with cisplatin …
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Effects of TGF-β Inhibitor on Chemoresistance in Ovarian Cancer Models
… Factor-β (TGF-β) was linked to poor prognosis, chemoresistance and metastasis risk in HGSC. Mechanisms include roles of TGF-β promoting epithelial to mesenchymal transition (EMT) and immune evasion via suppression of Granzyme B (Gzmb) and Perforin (Prf1) expression in cytotoxic T cells. We …
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Proteogenomic Insights Into The Nature Of Chemoresistance In Chronic Myelogenous Leukemia
Chronic Myelogenous Leukemia (CML) is a hematopoietic cancer caused by the formation of the Philadelphia chromosome, a reciprocal translocation of the ABL1 oncogene on chromosome 9, and the breakpoint cluster region gene (BCR) chromosome 22, resulting in the BCR-ABL oncoprotein. BCR-ABL is a …
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INVESTIGATING EPIGENETIC MECHANISMS OF CHEMORESISTANCE IN OVARIAN CANCER: THE ROLE OF H3K27ME3
… mechanisms linking H3K27me3 loss to the onset of chemoresistance in EOC, we generated in vitro platinum-resistant cell line models by exposing the platinum-sensitive A2780 cells to increasing concentrations of Carboplatin (CBP). The induction of platinum-resistance correlates with a decrease of …
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The Role of the Aryl Hydrocarbon Receptor in Tumor Growth and Chemoresistance
… toxins can contribute to the growth and chemoresistance of OSCCs. Nude mice tongues were injected with a human OSCCs cell line, SCC2s, and treated with an AHR antagonist at 25mg/kg daily via oral gavage. Primary tumor growth was measured via calipers and IVIS imaging. RT-qPCR analysis of …
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Isolation and characterisation of canine osteosarcoma cells to investigate mechanisms of chemoresistance
… dogs. It is thought that this is mainly due to chemoresistance and relapse, and our research group has recently identified autophagy as a potential mechanism for chemoresistance in human OSA, although the role of autophagy in canine OSA chemoresistance is still unknown. Due to the fact that pet …
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GLIOBASTOMA MULTIFORME UTILIZES SYSTEM Xc¯ FOR SURVIVAL UNDER OXIDATIVE STRESS AND PROMOTES CHEMORESISTANCE
<p>Glioblastoma multiforme (GBM) is a grade IV astrocytoma and is the most aggressive malignant primary brain tumor in adults. Without treatment, patients are expected to survive an average of three months. Conversely, current treatment regimens only extend survival to 12-14 months. …
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PLGA-DS reverses chemoresistance in malignant mesothelioma by targeting hypoxia induced cancer stem cells
… treatment. MM recurrence is unavoidable due to chemoresistance. Long-term inflammation triggered by asbestos activates a key transcription factor, nuclear factor-κB (NF-κB), which is further upregulated in cancer stem cells (CSCs) by hypoxia. Both hypoxia and NF-κB pathway plays a pivotal role …
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Genomic Evolution of Chemoresistance In Triple-Negative Breast Cancer Delineated By Single Cell Sequencing
… (NAC). Currently, the genomic basis of chemoresistance remains poorly understood. An important question is whether resistance to chemotherapy is driven by the selection of rare pre-existing subclones with genomic mutations and transcriptional programs that confer resistance to …
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