Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 294 for “"Chemokines"”.
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Chemokines as therapeutic targets in systematic inflammatory response syndrome
… dysfunction, organ failure and eventually death. Chemokines, a large family of small chemotactic cytokines, are critical inflammatory mediators in the development of both acute pancreatitis and sepsis. The present study has shown that blockage of CCR1 by a small molecule CCR1 antagonist has …
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The Novel Purification and Biophysical Characterization of CXC Chemokines
The chemokines are small, signaling proteins responsible for leukocyte recruitment through concentration gradient driven responses for inflammatory diseases such as tissue damage or sun burn, tumor suppression and regulation, and obesity from insulin resistance. In particular, the CXC family of …
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Cytokines and chemokines in the pathogenesis of low back pain
… the production of numerous cytokines and chemokines (chemoattractant cytokines) by the human IVDs’ native cell population. Detailed gene and protein expression studies identified several novel cytokines and chemokines that are differentially expressed in cells isolated from degenerate or …
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Suppression of LPS-induced cytokines/chemokines production by CXCL1 siRNA
… inhibition of LPS-induced pro-inflammatory chemokines, kinases, transcriptional factors, and apoptotic gene. CONCLUSIONS: This is a promising study regarding the mechanism of CXCL1 in the LPS-dependent pathway. CXCL1 is involved in the LPS-induced proinflammatory cytokine production through …
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The roles of the chemokines CXCL12 and CXCL16 in breast cancer.
A growing body of work implicates chemokines and their receptors in the progression of various types of cancer, including breast cancer. However, as potent chemotactic factors for leukocytes, chemokines also have the potential to enhance anti-cancer immunity. Evidence suggests that the chemokine …
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Enzymatic cleavage of chemokines CCL2 and CXCL10 : Implications for multiple sclerosis pathogenesis.
… nervous system (CNS). Chemotactic cytokines (chemokines), contribute to the recruitment of immune cells into the CNS, and are expressed by astrocytes, the most abundant cell type in the CNS, and endothelial cells. CCL2 and CXCL10 are chemokines expressed in MS lesions, which are thought to be …
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The in vitro effects of chemokines on microglia: Implications for multiple sclerosis.
… TNFalpha and respond by secretion of cytokines, chemokines, proteases, nitric oxide and superoxide radicals. As MS is a putative autoimmune disease of the CNS, chemokines (chemotactic cytokines), secreted by many cell types including T cells and macrophages in MS lesions, have been postulated as …
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Investigating the Role of Chemokines in Neutrophil Recruitment and Resolution During Inflammation
… including the chemokine family. Chemokines bind to cognate G protein-coupled receptors to induce cell migration and are upregulated in many chronic inflammatory diseases characterised by aberrant immune cell migration. While chemokines represent an attractive therapeutic target, …
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Regulation Of Neutrophil Homeostasis By Chemokines Signaling Through The Cxcr2 And Cxcr4 Receptors
The number of neutrophils in the blood is tightly regulated to ensure adequate protection against microbial pathogens while minimizing damage to host tissue. Neutrophil homeostasis in the blood is achieved through a balance of neutrophil production, release from the bone marrow, and clearance from …
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The role of chemokines in the pathology of multiple sclerosis and other neuroinflammatory diseases
… that in SSPE CNS the interferon -y-inducible a chemokines IP-10 and Mig, predominantly expressed by astrocytes and microglia, play a role in lesion formation. In contrast, the ßchemokine MEP-la, expressed both by perivascular macrophages and resident microglia, plays a role in the recruitment of …
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HIV-1 gp120 and Methamphetamine-mediated Induction of Proinflammatory Cytokines/chemokines and Oxidative Stress in Astrocytes: Implications in Neuroinflammation
… induction of various pro-inflammatory cytokines/chemokines and oxidative stress. In order to test these hypothesis four different studies were designed. We also investigated the mechanism(s) and pathways involved in the functional interaction between gp120 and MA. Furthermore, in order to …
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The effect of HIV-1 Tat and methamphetamine on expression of cytokines/chemokines and synaptic genes: Implications in HIV neuroAIDS
… mechanisms including production of cytokines/chemokines and decreased expression of neuroplasticity genes. The present study was based on the central hypothesis that HIV-1 Tat and methamphetamine work synergistically in mediating pro-inflammatory cytokines and decreasing synaptic proteins. The …
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Biochemical Characterization of CXCR4 Interactions With HIV -1, Natural Ligands and De Novo Designed Inhibitors
Chemokines and their receptors are implicated in a wide range of human diseases including Acquired Immune Deficiency Syndrome (AIDS) and HIV-associated dementia (HAD). The entry of human immunodeficiency virus type 1 (HIV-1) into the cell is initiated by the interaction of its surface envelope …
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On the role of mast cells in chemokine-induced leukocyte recruitment
… of inflammatory mediators, such as TNF-alpha and chemokines. Chemokines are effective leukocyte attractants and according to structural properties, chemokines are divided into two major subfamilies, CC and CXC. In general, CC chemokines exert chemotactic influence on monocytes and lymphocytes …
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Investigation of chemokine expression and modulation following traumatic brain injury
… described. Chemotactic cytokines, known as chemokines, are mediators of leucocyte recruitment and activation. Expression of chemokines and the resultant recruitment of leucocytes into the brain are generally thought to be integral to the enlargement of cerebral contusions which accompany …
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The Role of SDF1/CXCR4 Signaling in Opioid-Induced Hypernociception
… that has yet to be adequately explored is chemokines. Chemokines role in OIH is warranted given recent studies demonstrating the interaction between opioids and chemokines. Chemokines were originally thought to solely function in the immune system, but have recently been found to play a …
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Antibacterial peptides - key players in host defense at epithelial surfaces
… pharyngitis, high concentrations of the chemokines CXCL9/MIG, CXCL10/IP-10, CXCL11/I-TAC were found in tonsil fluid. Similarly, these chemokines were produced by activated pharyngeal epithelial cells in vitro. CXCL9/MIG was the predominant chemokine and also the most potent in killing …
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Dendritic Cell Migration and Traction Force Generation in Engineered Microenvironments
… We first characterize DC random motility (chemokinesis) on extracellular matrix proteins in the presence of chemokines. Then, using a microfluidic device, we present both single and competing chemokine gradients to murine bone-marrow derived DCs in a controlled, time-invariant …
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Role of N-terminal residues of CCL19 and CCL21 in binding and activation of CCR7
Chemokines are chemotactic cytokines, which mediate cell trafficking and play a key role in mobilisation of leukocytes. More recently, chemokines and their cognate receptors have been described as key players in different aspects of cancer biology contributing to proliferation, angiogenesis and …
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Ras Intrinsic and Extrinsic Pathways in Human Cancer
… oncogenic Ras led to secretion of all ELR+ CXC chemokines in oncogenic Ras driven tumor cell lines, a mouse tumor, a human tumor, and were sometimes elevated in the serum of pancreatic cancer patients, the cancer most associated with oncogenic Ras mutations. Moreover, knockdown of one of these …
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