Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Chemokine CCL2"”.
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The chemokine CCL2/CCR2 signaling mediates cancer associated fibroblasts-cancer cells interaction and promotes basal-like breast cancer progression
… understood. We previously identified that the chemokine CCL2 was highly expressed in breast cancer associated fibroblasts. CCL2 is known to recruit monocyte/macrophage and promotes cancer progression. We previously found that recombinant CCL2 can directly signal to breast cancer cells and …
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Endogenous Mechanisms Regulating Myeloid Cell Mediated Inflammation During Acute Lung Injuries
… which was dependent on the upregulation of the chemokine, CCL2, in the alveolar space. Together, the studies described in this dissertation point to two previously unappreciated mechanisms that serve to limit the pro-inflammatory processes of macrophages and limit tissue damage during ALI. …
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Assessing The Outcomes of Blocking Ccl2-Ccr2 Signaling Axis On Breast Cancer Brain Metastasis
… signaling and increases the secretion of the chemokine CCL2, which enhances the chemotaxis of CCR2<sup>+</sup> myeloid cells, a major subpopulation of bone marrow-derived myeloid cells (BMDMs), from peripheral blood into the brain tumor microenvironment (TME), eventually promoting brain …
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Investigating the role of the CCL2/CCR2 axis in monocytes and its modulation by extracellular nucleotides
The chemokine CCL2 activates its cognate receptor CCR2 to orchestrate monocyte trafficking towards infected, inflamed, and injured tissues during immune responses and the development of inflammatory disease. However, despite research into this area being plentiful, CCR2 antagonists have lacked …
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Role of Macrophages in Ocular Surface Fibrosis
… was quantified using real-time PCR. Finally, chemokine release from macrophages was analyzed using real-time PCR and bead-based immunoassay.</p> <p>Our data demonstrates successful generation of M0 macrophages and their polarization into M1 and M2 phenotypes as confirmed by gene quantification …
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LKB1, CCL2, and Macrophages: A New Axis of Endometrial Cancer Progression
… dependent secretion of the inflammatory cytokine CCL2. Lkb1 inactivation in vivo resulted in abnormal production of CCL2, which led to recruitment of pro-tumorigenic macrophages (aka immunosuppressive macrophages) responsible for tumor invasion. Conditional inactivation of Ccl2 in an Lkb1-driven …