Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 106 for “"Chemoattractant"”.
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Neutrophil Chemotaxis in Multiple Chemoattractant Gradients
… process, a number of chemical signals, called chemoattractants, are produced at or proximal to sites of infection and diffuse into the surrounding tissue. Immune cells sense these chemoattractants and move in the direction where their concentration is greatest, thereby locating the source of …
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Engineering chemoattractant gradients using controlled release polysaccharide microspheres
Chemoattractant gradients play important roles in the normal function of immune system, from lymphocyte homeostasis to mounting efficient immune responses against infection. Improved fundamental knowledge about the role of chemoattractant gradients developed around single source cells in …
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Expression and regulation of monocyte chemoattractant protein-3 (MCP-3) in fibrosis
… explores the expression of chemokine, monocyte chemoattractant protein-3 (MCP-3/CCL7) in SSc and in murine models for SSc: type 1 tight skin mouse (Tsk1) and a transgenic mouse strain (TβRIIΔk) in which there is fibroblast-directed disruption of TGFβ signalling. The hypothesis that crosstalk …
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BIOLOGICAL AND TRANSDUCTIONAL EFFECTS OF ALLOSTERIC ANTAGONISTS ON THE ACTIVITY OF CHEMOATTRACTANT RECEPTORS
There are two major chemokine receptors expressed on the surface of neutrophils, CXCR1 and CXCR2.It is thought that targeting both receptors may be necessary for optimal inhibition of PMN influx in several inflammation disorders such as post-ischemia reperfusion injury, pulmonary fibrosis, sepsis, …
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A large scale analysis of chemoattractant induced cytoskeletal dynamics in Dictyostelium discoideum by means of proteomic and imaging approach
… response is a biphasic character of the chemoattractant-induced actin polymerisation. The two temporally distinct phases of actin polymerisation reveal very different characteristics and regulation, but the exact mechanisms responsible for these differences have not been determined. We …
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Investigation of Neutrophil-Like HL-60 Cell Migration in a 3D Collagen Matrix
… against invading pathogens. In the presence of chemoattractants, these cells are the first responders that start a directed migration toward the injured area. As neutrophils approach the site of infection, they transmigrate to the tissue and follow the chemoattractant concentration gradient to …
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Poly(ethylene glycol) hydrogel microspheres as a controlled release device
… glycol hydrogel microspheres that encapsulate a chemoattractant. This study was performed to determine whether the diffusion of the chemoattractant could be controlled by varying the amount of crosslinker and by incorporating ionic groups in the polymer matrix. It was found that the crosslinker …
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Nanoparticle effects on cell migration
… of cells in response to a chemical stimulus. Chemoattractants are inorganic and organic substances, usually proteins, that create a concentration gradient that attracts cells to move towards them. Chemoattractants are known to be involved in immune responses and wound healing processes in …
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Chemotaxis of Sperm Cells
Sperm cells are guided to the egg by chemoattractants in many species. Sperm cells are propelled in a liquid by the regular beat of their flagellum. In the presence of a concentration gradient of a chemoattractant, they can steer upwards the concentration gradient, a process called chemotaxis. Eggs …
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A Mathematical-Experimental Strategy to Decode the Complex Molecular Basis for Neutrophil Migratory Decision-Making
… an infection in the tissue, chemical cues called chemoattractants are released, which signal neutrophils to exit circulation and enter the tissue. Once in the tissue, neutrophils directionally migrate in response to the chemoattractant and toward the site of infection in a process called …
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Aging Delays and Exercise Accelerates Wound Healing and Decreases Inflammation in Old Mice
… (IL-1beta), interleukin-6 (IL-6), keratinocyte chemoattractant (KC), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor alpha (TNF-alpha). No significant differences in wound size were found as a result of exercise in young mice. However, exercise significantly decreased wound …
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The response of human spermatozoa to chemoattractants
The effect of the chemoattractant bourgeonal on [Ca\(^{2+}\)]i and chemotaxis in human sperm was investigated. Burgeonal induced a dose-dependent, slowly-developing tonic elevation in [Ca\(^{2+}\)]i, The response was dependent on capacitation. In low-Ca\(^{2+}\) or EGTA-buffered saline the response …
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INITIATION OF EXPERIMENTAL ACUTE PANCREATITIS AND MODULATION OF INFLAMMATORY RESPONSE
… causes early expression of CCL2 [monocyte chemoattractant protein-1 (MCP-1)] and subsequent early influx of monocytes. Increased expression of CXCL [cytokine-induced neutrophil chemoattractant-1 (CINC-1)] was not seen and neutrophils were shown to appear in the tissue later during the …
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Platelet micro-particles induce angiogenesis through the delivery of the micro-RNA Let-7a into endothelial cells
… of proangiogenic proteins including monocyte chemoattractant protein-1 and placental growth factor, and recruitment of activating transcription factor-4 protein to their promoter regions were explored. Main findings are: 1. Platelet micro-particles induce angiogenesis, migration, and release …
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Investigations of collective cell movement during gastrulation in the chick embryo
… progenitors to gradients of potential chemoattractants and assess their migratory behaviour in real-time. We established an in vitro assay that enables the isolation of the cells from the embryo with minimal damage and their preservation in serum-free conditions. We then used the Dunn …
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Development and Characterisation of a Vessel-On-a-Chip Model of Inflammation and Inflammatory Haemostasis
… and promoted neutrophil transmigration towards a chemoattractant gradient. Differences in neutrophil transmigration were observed depending on ECM composition. Neutrophils migrated in higher number, further, and did not require a chemoattractant gradient in vessels cultured against a mixed matrix …
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Molecular mechanisms of signal transduction in neutrophil chemotaxis
… during chemotaxis. Depletion of Lyn abolished chemoattractant-induced Rap1 activation at the cell's leading edge. Furthermore, Lyn controls spatial activation of Rap1 by recruiting the CrkL/C3G protein complex to the leading edge. Together, these results provide novel mechanistic insights into …
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Microfluidics for bacterial chemotaxis
… videomicroscopy and cell tracking in controlled chemoattractant gradients. Previously, transport parameters have been derived theoretically from single-cell swimming behavior using probabilistic models, but the mechanistic foundations of this up-scaling process have not been proven …
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Association Between Fluoride Exposure and Immune System Biomarkers in Pregnancy
… tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and C- reactive protein (CRP) from plasma samples collected during the third trimester of pregnancy. Results: We observed a departure from linearity in the association between WFC and CRP, such that CRP levels …
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Quantitative Image Analysis in the Study of Neutrophil and Neutrophil-Like HL-60 Chemotaxis
… responders of the innate immune system. External chemoattractant signals result in neutrophil polarization: the neutrophil forms a leading edge (front) which constantly protrudes and retracts actin-rich pseudopods, and a contractile myosin-enriched trailing edge (back) which is insensitive and …
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