Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Chemistry and Chemical Biology"”.
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Synthesis of Structurally Diverse N-Substituted Quaternary Carbon Containing Small Molecules and Their Application as Novel Starting Points for Drug Discovery
… are urgently required to seed both medicinal chemistry and chemical biology research. Within the two last decades, however, organic synthesis has been identified as a limiting factor in this regard owing to the historically uneven exploration of chemical space. Whilst fragment-based screening …
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Dual c–h functionalization of n-aryl amines & development of novel hydrogen bonding catalysts
… We have recently reported an efficient and alternative oxidative Povarov approach, along with its application in synthesis of polycyclic amines. This reaction features dual C–H activation, which in addition to α-functionalization of C(sp3)–H bonds of amines, simultaneously results in the …
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The Synthesis of Naphthalene-Containing Compounds and Materials Using Benzannulation Reactions
… building blocks for further derivatization and iterative benzannulation to access sterically crowded substrates (Chapter 2). Despite the high efficiency of this reaction, phenylene ethynylene macrocycles prove to be too rigid to undergo complete benzannulation (Chapter 3). Finally, the scope …
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Development of Protein Degraders Inspired by Chemical Modifications
… in this thesis focus on the development of the chemical modification-inspired dehydroalanine (Dha)-based protein degraders, including their synthesis, optimization, mechanistic elucidation, and transferability assessment. First, a Dha-based bromodomain-containing protein 4 (BRD4) degrader was …
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INVESTIGATION OF CARBON DOTS BEHAVIOR: DIFFUSIOPHORESIS AND INFLUENCE ON THE OIL-WATER INTERFACES
… are promising for enhanced oil recovery, medical and environmental applications, but the successful implementation of CDs in these fields needs a comprehensive understanding of their transport behavior within solvent gradients and their influence on interfacial tension and surface wettability.In …
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Multidimensional Spectra from Classical trajectories
… an important role in determining the dynamical and structural properties of chemical and biological systems. Exact quantum dynamical calculations for large complex systems are difficult. That opens the window for approximations to quantum dynamics to incorporate quantum effects in the …
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Understanding the Vibrational Features of Hydrogen-Bonded Dimers
Hydrogen-bonded systems often exhibit very broad and unusually shaped features in their vibrational spectra. The origin of these features is oftentimes unclear. Consequently, computational methods are frequently used to model these features in order to better understand their origin. However, …
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Elucidating the Reactivity of Cytochrome P460: Maturation, Product Selectivity, and Substrate Scope
… will address the reactivity of cytochrome P460 and put it into the context of AOB metabolism. Cytochrome P460 can catalyze a variety of reactions, both as the proenzyme and matured cross-linked enzyme. I will interrogate the mechanisms employed by cytochrome P460 using a combination of …
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Noncovalent Functionalization Of Graphene
… to graphene through three pyrene moieties and projects easily varied functionality away from the surface. The thermodynamic and kinetic binding parameters of a tripod bearing a redox-active Co(II) bisterpyridyl complex were investigated electrochemically. The complex binds strongly to …
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Semiclassical Approaches to Complex Chemical Simulation in Real Time
… a pedagogically rich connection between quantum and classical perspectives of nature, and, furthermore, is a promising approach to incorporating quantum effects into molecular dynamics simulations. However, a variety of numerical challenges associated with SC methods, such as the cumbersome …
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Materials For Energy: Complex Oxides And Nitrides For New Polymer Electrolyte Membrane Fuel Cell Catalysts And Supports
… for large-scale commercialization of PEMFCS, and must be stable in low pH (1-2) and up to +1.5 V (vs. SHE). The material also needs to be porous and conducting (at least 0.1 S cm-1). Furthermore, the catalyst support should also be capable of strongly binding Pt or Pt-based catalysts. Previous …
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Catalytic Studies Of Noble Metal Nanocatalysts Using Single-Molecule Fluorescence Microscopy
… level from many particles on a camera and fitting the emitted point spread function to a two-dimensional Gaussian function, sub-diffraction spatial resolution of ~25 nm was achieved. By overlaying the optical imaging results onto a scanning electron microscopy (SEM) image of the same …
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A Study Of Novel Activities Of Type Iii Sirtuins: Cobb And Pfsir2A
… that many cellular proteins are acetylated and are regulated by post translational modifications. Although initially, sirtuins gained notoriety when Sir2 yeast was discovered to increase life span under calorie restriction, current research suggests that sirtuins are involved in a myriad of …
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DEVELOPMENT AND APPLICATION OF CHEMOENZYMATIC TOOLS TO VISUALIZE MAMMALIAN PHOSPHOLIPASE D SIGNALING
Chemical imaging techniques have been instrumental in advancing our understanding of the spatiotemporal regulation of signal transduction pathways. Phospholipase D (PLD) enzymes are a critical signaling node responsible for production of the pleiotropic lipid second messenger phosphatidic acid via …
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Tissue Transglutaminase And Its Role In Human Cancer Progression
… in a novel EGFR/Src-signaling pathway and a potential target for inhibiting EGFR-promoted tumor progression. Specifically, EGF up-regulates tTG expression in human breast cancer cells, and knock-downs of tTG expression or the treatment of breast cancer cells with a tTG-specific …
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Investigating C. Elegans Small-Molecule Signaling Pathways Via 2D-Nmr Based Comparative Metabolomics
Molecular interactions provide the basis and structure of all life and living systems. Specifically, small molecules are principle mediators of essential processes across phyla, including signal transduction and metabolism, as well as interorganismal chemical attraction and defense. Therefore, the …
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Mechanistic Investigations Into The Thermal C-C Bond Forming Cyclization Of Metal Pyridine-Enamide Complexes And The Synthesis And Reactivity Of Cationic And Neutral Iron(Iv) Alkylidene Complexes
… pyridine adduct resulted in intraligand CC coupling to form an indolamide ligand. Control experiments with the corresponding lithium pyridine-enamide afforded the same indolamide. In order to probe the mechanism of cyclization, deuterium labeling experiments for the lithium …
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The Heme-Lysine Cross-Link of Cytochrome P460: Effects on Catalysis and Mechanism of Formation
… NH3-oxidizing bacteria (AOB), anammox bacteria, and comammox bacteria the enzyme hydroxylamine oxidoreductase (HAO) is able to convert hydroxylamine (NH2OH) to nitric oxide (NO). What makes HAO unique is the presence of a P460 cofactor, which has been observed in only one other known protein …
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