Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 88 for “"Chemistry, Pharmaceutical."”.
-
Synthetic Studies on Small Molecule Modulators of Src Homology 2 (SH2) Domain-Containing Inositol 5’-Phosphatase (SHIP)
… become a hotly pursued area in medicinal chemistry. Pharmaceutical targeting of SHIP with small molecules has been identified as a new method to directly influence the phosphoinositide 3-kinase (PI3K) cell signaling pathway. Modulation of this pathway may be utilized in the development of …
-
MOLECULAR MODIFICATION OF SOME ATROPINE-LIKE ANTICHOLINERGICS AS PROBES FOR MUSCARINIC RECEPTORS.
MOLECULAR MODIFICATION OF SOME ATROPINE-LIKE ANTICHOLINERGICS AS PROBES FOR MUSCARINIC RECEPTORS.
-
Bioactive constituents of Broussonetia papyrifera and Antirhea acutata.
Bioactive constituents of Broussonetia papyrifera and Antirhea acutata.
-
Structure elucidation of sweet and bitter principles of Polypodium glycyrrhiza.
Structure elucidation of sweet and bitter principles of Polypodium glycyrrhiza.
-
CHEMICAL PATHWAYS FOR THE PREPARATION OF LABELED DERIVATIVES OF DIHYDROXYACETONE.
CHEMICAL PATHWAYS FOR THE PREPARATION OF LABELED DERIVATIVES OF DIHYDROXYACETONE.
-
Design, synthesis, and evaluation of rigid probes for the monoamine transporters.
Design, synthesis, and evaluation of rigid probes for the monoamine transporters.
-
LINDANE METABOLISM: EPOXIDATION OF POLYCHLOROALKENES AND EFFECTS OF ROUTE OF ADMINISTRATION ON EXCRETION.
LINDANE METABOLISM: EPOXIDATION OF POLYCHLOROALKENES AND EFFECTS OF ROUTE OF ADMINISTRATION ON EXCRETION.
-
Membrane interaction QSAR analysis: Methods and applications.
Membrane interaction QSAR analysis: Methods and applications.
-
Stereoselective metabolism of verapamil and four other chiral drugs by cDNA expressed CYP450's.
Stereoselective metabolism of verapamil and four other chiral drugs by cDNA expressed CYP450's.
-
Functional ionic liquids for use in pharmaceutical applications
For years, the pharmaceutical industry has relied heavily on crystalline active pharmaceutical ingredients (APIs) that can be approved by the Federal Drug Administration (FDA) as neutral compounds, salts, or solvates of said neutral compounds and salts. Yet, the solid crystalline form can have …
-
New paradigm for drug design: Design and synthesis of novel biologically active peptides that are agonists at opioid receptors and antagonists at cholecystokinin receptors
We now know from genomics that many disease states lead to changes in expressed proteins (adaptation/plasticity). Therefore, drug design and discovery based on normal states and single targets often is inadequate or even counter-indicated. Therefore, the "system changes" that have occurred must be …
-
Elucidating Targets for Infectious Diseases and Cancer: A Computational Approach
Cancer and infectious diseases represent huge health threats to societies around the globe. Bisphosphonate drugs, long known for their ability to treat bone resorption diseases, have also served as the template for designing new agents against a variety of other diseases. In this work, …
-
The Total Synthesis and Cytoprotective Abilities of Dykellic Acid and Its Structural Analogs
Experiments were also carried out to establish if dykellic acid's biological activity can be attributed to either of two well-established mechanisms, ROS quenching or caspase inhibition. Using fluorescent dyes sensitive to ROS it was established that dykellic acid is not capable of directly …
-
Targeting RNA With Small Molecules: SL3 of HIV -1 Psi-Rna
SL3 RNA of HIV-1 is the principal packaging determinant through its interaction with viral nucleocapsid protein, NCp7. Since SL3 is not a target of current anti-HIV therapeutics, the discovery of small molecules that target SL3 would not only expand the understanding of RNA recognition by small …
-
Synthesis of Delta(3)-Imidazolines as Latent Forms of Peptidyl Trifluoromethyl Ketones
Many trifluoromethyl-substituted imidazolines were efficiently synthesized directly into larger peptides, by use of carbamate-protected amino acid fluorides as the initiator of the dipolar cycloaddition. The imidazolines then functioned as a protecting group for the trifluoromethyl ketones during …
-
Technetium-Labeled Receptor-Specific Radiopharmaceuticals: Synthesis of oxorhenium(V) Mimics of Steroid Hormones Based on the Integrated Approach
Tetradentate oxorhenium(V) coordination motifs were subsequently investigated as possible modes by which the metal-chelate may be incorporated into a steroid-like structure. A novel amine amide thioether thiol (AATT) chelation paradigm was devised to replace the C and D rings of the steroid with a …
-
Application of Chemiluminescent Detection to a Capillary Electrophoresis System Contained on a Glass Slide and the Development of Non-Flowing Electrogenerated Chemiluminescence Probes
A capillary electrophoresis system contained on a micromachined glass slide which integrates chemiluminescence as the detection method has been constructed and demonstrated as a feasible analytical technique. A simple method which does not require highly specialized facilities to manufacture these …
-
Separation and Structure Characterization of Biologically Important Substances
An attempt was made to isolate urease inhibitors from commercial Yucca schidigera extract. Trans-3,3$\sp\prime$,5,5$\sp\prime$- tetrahydroxy-4-methoxystilbene was isolated and its structure was assigned. Biological tests indicated that it was a urease inhibitor, and that it was also active against …
-
Design, Syntheses and Functional Studies of DNA Binding Metal Complexes
Both cis- and trans- (Pt(NH$\sb3)\sb2$(4-Me-Py)Cl$\rbrack\sp+$ bind DNA covalently at the N7-site of the guanines forming a monodentate adduct, but only the cis-isomer has anticancer activity. The interactions of these platinum complexes with the DNA-heptamer d(CCTGTCC):d(GGACAGG) were examined and …
-
Characterization of Bioactive Compounds by Mass Spectrometry and Nuclear Magnetic Resonance
In the last part of this project, ESIMS and ESIMS/CID/MS were employed to profile eicosanoids in different cell cultures. Eicosanoids are fatty acid derivatives with a variety of extremely potent hormone-like actions on various tissues of vertebrate animals. Profiling eicosanoids by mass …
Page 1 of 5