Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 206 for “"Chemicals and Drugs"”.
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Natural Language Processing Methods to Automatically Parse Eligibility Criteria in Dietary Supplements Clinical Trials
… (DSs) have been widely used in the U.S. and evaluated in clinical trials as potential interventions for various diseases. However, many clinical trials face challenges in recruiting enough eligible patients in a timely fashion, causing delays or even early termination. Using electronic …
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Informatics Approaches to Linking Mutations to Biological Pathways, Networks and Clinical Data
… genome has begun to transform human biology and genetic medicine. The discovery of functionally important genetic variation lies at the heart of these endeavors, and there has been substantial progress in understanding the common patterns of single-nucleotide polymorphism (SNP) in humans- the …
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Investigation of porcupine bezoar extract (Hystrix Brachyuran) on hela cell combined with electroporation method
… pulses that can lead to a variety of biophysical and biochemical responses. It is a molecular biology technique that stimulates pores through cell membrane, to increase the permeability of the cell, allowing chemicals, and drugs or Deoxyribonucleic acid (DNA) to be introduced into the cell. In …
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The comparative efficacy of inhaled methoxyflurane and intranasal fentanyl for the pre hospital management of cardiac and or visceral pain
OBJECTIVE: To investigate the comparative safety and efficacy of inhaled Methoxyflurane and intranasal Fentanyl for the management of pain of cardiac or viscera/ aeitology and to secondly assess the usefulness of an alternative pain assessment tool utilised by the WA Ambulance Service. DESIGN: …
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The Transformation of Human Retinal Pigment Epithelial Cells
… (PVR) is a fibrotic eye disease and the most common cause of fail ure of retinal reattachment surgery. Although the etiology of this disease is unknown, TGFβ has been implicated as a key factor contributing to PVR.</p> <p>The risk factors of PVR include a tear on the neural …
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Cytokine Dysregulation Promotes HPV Persistence
… exposed to genital HPV, infection persists and can progress to cervical carcinoma. The inability to maintain the appropriate cytokine milieu in the cervical mucosa has been implicated in HPV persistence. The switch from a predominantly Type 1 cytokine response to a predominantly Type 2 …
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Impact of Oxytocin and Tetrahydrocannabinol on signs of fear in the rat
… delta-9 (psychoactive component of cannabidiol) and delta-8 (delta-9 isomer) THC pre-treatment on attenuating signs of fear in the rat. METHODS: For each experiment, male Sprague-Dawley rats were divided into 5 groups, (n=8 per group); 1.) controls (vehicle and no foot shock), 2.) shock (vehicle …
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5-HT3 Receptor Ligands and Their Effect on Psychomotor Stimulants
Drug abuse and addiction are considered to be a result, at least in part, of the rewarding effects produced by increasing dopamine levels. 5-HT3 serotonin receptors have been shown to indirectly affect dopamine levels. Therefore, the effect of the 5-HT3 receptor partial agonist, MD-354, on the …
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The Complex Association Between Cholesterol Metabolism and Cancer Risk
… is a leading cause of death in the United States and has consequently sparked a great deal of research into factors that might influence the cardiovascular system (Roger et al., 2012). Total serum cholesterol levels (TC) have been found to significantly correlate with cardiovascular diseases …
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Human Factors Contributing to Preventable Adverse Drug Events in Healthcare: A Grounded Theory Approach Pilot Study
… on the interview of individuals with first-hand experience with the phenomenon of interest. A total of 10 participants, eight nurses and two physicians, with varying levels of experience and places of employment, were recruited for these interviews. The resultant data were analyzed, coded, …
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Mapping Major Genetic Factors of Obesity
… world, the prevalence of obesity is increasing and has now reached a level deemed an epidemic. Obesity is a major public health concern as it is associated with much comorbidity including cancer, heart disease, and diabetes. The development of obesity is a result of many different factors, all …
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Review of drug and biologics recalls: 2009 through 2019
<p>This study analyzed drugs and biologics recalls for the period of 2009 and 2019. The data used in the study was generated from Food and Drug Administration records. A total of 466 drugs and 84 biologics were recalled during the 11-year period. The common causes of drug product recalls included …
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Differential Regulation of Synaptic Plasticity In Epilepsy
… characterized by spontaneous recurrent seizures and associated comorbidities. Examining alterations in synaptic plasticity can give us insight into the epileptogenic phenotype as well as accompanying conditions like cognitive decline and psychosis that may be observed in subjects with TLE. We …
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Developmental Resilience to Dopaminergic Vulnerability Associated With Human Immunodeficiency Virus
<p>HIV can induce marked and debilitating neurologic complications in infected children, often in spite of the use of Highly Active Antiretroviral Therapy. Clinical observations suggest a specific vulnerability of dopaminergic neurons, yet few studies have examined the possibility that these …
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Benefits of Quercetin on Metabolic and Inflammatory Biomarkers in High Fat Diet Induced Obesity: A Dose Response Study
… 2 diabetes, hypertension, degenerative diseases and a wide array of cancers. For this reason, dietary supplements with anti-inflammatory properties have been the focal point of many recent studies on diet-induced obesity. Quercetin, a polyphenolic compound found in many fruits and vegetables, is …
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Dual Mechanism Analgesia-Enhancing Agents
… studies have shown that both 5-HT3 receptors and α2B- adrenoceptors play a role in antinociception. MD-354, N-(3-chlorophenyl)guanidine, has a high-affinity both for 5-HT3 and α2B- adrenoceptors and could be viewed as the first example of a rather selective 5-HT3/α2B- adrenoceptor ligand. …
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Combination Therapy For the Treatment of Human Malignant Neuroblastoma
… is a tumor of sympathetic nervous system origin and the most common extracranial heterogenous solid tumor of childhood affecting primarily infants. Despite multimodal conventional therapeutic approaches including chemotherapy, radiation therapy, immunotherapy, and neurosurgery, the survival rate …
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The Biomechanical Role of Cancer-Associated Fibroblasts In Tumor-Stroma Reciprocity
… been found to influence tumor cell proliferation and metastasis with increased stiffening of the extracellular matrix being a hallmark of tumorigenesis. This thesis examines the role of the extracellular environment surrounding tumors, the tumor stroma, and investigates what effects the components …
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