Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Chemical nociception"”.
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Evaluation of the Functional Roles of TRPA1 Homologs, Painless and dTRPA1, in Chemical Nociception in Drosophila
The detection of harmful chemical irritants is important for the avoidance of potential tissue-damaging and life threatening compounds. There are multiple physiological systems that exist to detect these irritants, and one specific target of these compounds is the TRPA1 channel. Drosophila possess …
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Allosteric Modulation of Metabotropic Glutamate Receptor 5 as a Treatment for Pain
… I found Fenobam to be analgesic in models of chemical nociception and inflammatory pain. Fenobam was also found to be without analgesic effect in mGlu5 KO mice, suggesting that its analgesic effect is mediated via mGlu5. Further assessment of both mGlu5 KO mice and the effects of fenobam …
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Isoform-Specific Roles of Extracellular Signal-Regulated Kinases in Pain
… are believed to be key signaling molecules in nociception and nociceptive sensitization. Studies utilizing inhibitors targeting the shared ERK1/2 upstream activator, mitogen-activated protein kinase kinase: MEK), and transgenic mice expressing a dominant negative form of MEK have established …