Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 121 for “"Chemical modifications"”.
-
Endogenous and chemical modifications of model proteins
Protein modifications are ubiquitous in nature, introducing biological complexity and functional diversity. Of the known post-translational modifications, glycosylation is one of the most common and most complex, yet some of the biological implications of this modification remain poorly understood. …
-
Development of Protein Degraders Inspired by Chemical Modifications
… in this thesis focus on the development of the chemical modification-inspired dehydroalanine (Dha)-based protein degraders, including their synthesis, optimization, mechanistic elucidation, and transferability assessment. First, a Dha-based bromodomain-containing protein 4 (BRD4) degrader was …
-
Development and characterization of chemical modifications for siRNA strand selection
… a role in canonical strand selection; however, chemical modifications can improve strand selection and activity. To evaluate the impact of novel chemical modifications on strand activity, an RT-qPCR-based target cleavage assay was developed and validated. Dose-response analysis highlighted the …
-
Chemical modifications of insulin and their relation to fibril formation.
Massachusetts Institute of Technology. Dept. of Biology. Thesis. 1945. M.S.
-
Advancing and expanding siRNA and saRNA therapeutics applications through chemical modifications
… this study focuses on incorporating new chemical modifications into the RNA and assessing their impact on RNA activity. Our aim is to enhance RNA therapeutic efficacy for potential cancer therapy applications. The first goal focused on creating a combination therapy for cancer treatment …
-
Chemical and Enzymatic Methods to Detect Chemical Modifications in Nucleic Acids
The bases of DNA and RNA are chemically modified in a variety of ways across all branches of life. DNA and RNA chemical modifications function as a layer of epigenetic information that regulate gene expression. Studies on the chemical reactivity of nucleic acids and the biochemical activity of …
-
Chemical Modifications and Passivation Approaches in Metal Halide Perovskite Solar Cells
… different physical properties of passivated and chemically modified hybrid metal halide perovskite materials and development of highly efficient charge transport layers for perovskite solar cells. We first developed an efficient electron transport layer via modification of titanium dioxide …
-
Condensation and Freezing Front Propagation on Surfaces With Topographic and Chemical Modifications
Experimental data on propagation were reported for a freezing front crossing on micro-grooved substrates in a 200mum-to-400mum-thick water layer. The speed of a freezing front oscillates locally over the grooves, with propagation retarded in troughs and accelerated on crests. When the water …
-
Exploring multivalency and chemical modifications in the development of anti-PD-L1 peptide inhibitors for cancer immunotherapy
… to design peptidomimetic analogs of TR3. These modifications improved the stability of the resulting analogs by about 5-fold. The analogs also exhibited enhanced anti-PD-L1 blocking potency with IC₅₀ values of 355 nM, 359 nM, and 165 nM for TR3-29, TR3-30, and TR3-64, respectively, compared to …
-
STUDIES ON NATURAL AND EDIBLE BIOPOLYMERS. ISOLATION, CHARACTERIZATION AND CHEMICAL MODIFICATIONS OF POLY(Γ-GLUTAMIC ACID) (Γ-PGA) FROM BACILLUS SUBTILIS
… efforts having been spent in investigating its chemical and biological properties, much lies ahead to be elucidated about this polymer biosynthesis and conformational aspects. In addition, its potential applications appear to be still almost unexploited in the Western world. This Ph.D. thesis …
-
Nmr Solution Structures Of Two Hairpins Of E. Coli 16s Rrna: The Effects Of Mutations And Chemical Modifications On Structure And Function Of Rrna
… crystal structure. The structural role of the modifications, however, is not obvious in the published crystal structures (2AVY and 1J5E), and the 970 loop structures in the two crystal structures have some differences, possibly because that the 970 loop hairpin can form multiple functionally …
-
Importance of zein composition in quality protein maize (QPM) to microstructural and chemical modifications of proteins during extrusion and their impact on texture of corn-based extrudates
… the effect of the high γ-zein content in QPM to chemical, physical, and microstructural changes that occurs in zeins during extrusion and its impact on texture of intermediate corn-based extrudates. Three experiments were designed to test the overall scientific hypothesis that high γ-zein content …
-
Epitranscriptomics : translational regulation of metabolism, drug resistance and proteostasis during cellular stress
… -- the naturally occurring system of chemical modifications on ribonucleic acid (RNA) --
-
Expanding the Scope of T3 DNA Ligase-Catalyzed Oligonucleotide Polymerizations (T3-LOOPER)
… field of therapeutics but are quite costly and chemically unstable. Nucleic acid polymers can mimic antibody therapeutics but are more cost effective to produce, can reversibly denature, and have a high synthesis reproducibility. These polymers are called ‘aptamers’. However, they lack in …
-
Engineering a Photo-Control Mechanism for RNA Interference
… gene silencing. Nucleic acid chemical modifications have been incorporated to improve their pharmacological properties. Despite numerous developments in chemical modifications for increased stability, safety, and efficiency of these therapeutic agents, they still face …
-
Studies on the Application of Multiwalled Carbon Nanotubes for the Thermal Treatment of Cancer
… through three aims: 1) To determine the role of chemical modifications in mediating blood toxicities during intravenous delivery, 2) To determine the cell type-specific effects of nanotube-mediated thermal treatments and 3) To determine the long-term efficacy of nanotube-mediated thermal …
-
Acrylamide Based Hydrogels for Continuous Wear Contact Lenses
… This has been achieved by making a number of chemical modifications to a simple acrylamide-based copolymer in order to produce a material of appropriate water content, oxygen permeability, mechanical strength, and long-term dimensional stability whilst not encouraging the accumulation of …
-
Chemical modification of polymers
… knowledge of PVC degradation and stabilisation, chemical modifications were imposed on degraded PVC and raw PVC with the aim of obtaining non-migrating additives. The modifications were carried out mainly in the presence of dibutyl maleate (DBM), and the resulting polymer contained dibutyl maleic …
-
Investigations into the molecular basis of enzyme-catalyzed reactions in natural product biosynthesis
… I describe my efforts to structurally and biochemically characterize enzymes capable of carrying out interesting chemical modifications. In the first chapter, I introduce a class of secondary metabolite termed the ribosomally synthesized and post-translationally modified peptides (RiPPs). The …
Page 1 of 7