Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 48 for “"Chemical inhibitors."”.
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Analyzing Resistance to Design Chemical Inhibitors of AAA Proteins
… drug's binding sites. As selective binding of inhibitors to their protein targets is mediated by specific interactions of the inhibitor with the protein backbone and side chains, mutations that disrupt these interactions can lead to resistance. Identifying resistance-conferring alleles can thus …
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Effects of Scale Reduction Technologies and Chemical Inhibitors on Calcium Precipitation in Premise Plumbing Systems
… including cation exchange softeners, electrochemical deionization, physical magnets or electric field generators, media induced precipitation, sacrificial media (phosphate), and sacrificial media (citric acid). While calcium carbonate precipitation within a water distribution system is …
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Discovery and Characterization of Novel Chemical Inhibitors of Wnt Ligand Production with Implications for Anti-Cancer Therapy
… interest has shifted towards achieving chemically based control over aberrant pathway responses, with the ultimate goal of creating therapeutic utility. To this end our laboratory screened a diverse 200K compound library using cell based transcriptional reporters and uncovered several …
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An Experimental Study on the Effects of Heat and Chemical Inhibitors on the Flow Behaviour of Waxy Crude Oils. The Effects of Heat and Chemical Inhibitors on the Rheological Properties of Waxy Crude Oils with regard to Pumping in Pipelines
Waxy crude oils (1/3 of oil produced worldwide), pumping through pipelines considered risky operation due to the crude wax content (15-40 wt.%) and to the temperature at which wax supersaturates and precipitates, leading to the danger of pipe blockage, eventually resulting, in multimillion dollars …
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Investigating the chemical space and metabolic bioactivation of natural products and cross-reactivity of chemical inhibitors in CYP450 phenotyping
… of years. Owing to the great diversity in chemical scaffolds they encompass, these compounds provide an almost limitless starting point for the discovery and development of novel semi-synthetic or wholly synthetic drugs. In Africa, and many other parts of the world, natural products in the …
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Electron Transfer Reactions of the Ubiquinol: Cytochrome C-2 Oxidoreductase of Rhodopseudomonas Sphaeroides
… through the use of optical spectroscopy and chemical inhibitors of the protein complex.
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Using Small Molecule Tools to Study ATPase Mechanoenzymes
… mechanoenzymes has been linked to diseases, and chemical inhibitors and activators can be powerful tools to probe mechanisms and test therapeutic hypotheses. However,the structural conservation across the AAA protein family makes designing selective chemical inhibitors challenging. Additionally, …
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Molecular mechanisms mediating the induction of apoptosis by chemopreventive selenium compounds
… and intervention studies using specific chemical inhibitors and/or dominant negative mutants suggested that INK, but not p38, was functionally important for the induction of apoptosis and Fasl. The relative levels of induction of INK activity and Fasl also correlated with the extent of …
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Methadone metabolism in placentas from preterm pregnancies
… aromatase. This was confirmed through the use of chemical inhibitors and monoclonal antibodies raised against specific CYP isoforms. The affinity of methadone to CYP19 remained relatively unchanged throughout gestation. However, the activity of the enzyme increased as gestation progressed, but …
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Assessment of dairy product quality by selective incubation and rapid techniques
… consisted of two phases. In the first phase, chemical inhibitors were evaluated for their ability to allow growth of gram-negative psychrotrophic bacteria while inhibiting growth of gram-positive organisms. Crystal violet, benzalkonium chloride, a mixture of crystal violet and benzalkonium …
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Algoritmo para cálculo de equilíbrio de fases com precipitação de parafinas
… usually mecanically remedied or mitigated by chemical inhibitors, what increases the costs of the production processes. Against such a background, a more economic and efficient approach consists in predicting the wax formation conditions by using simulators, which are still limited by low …
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Regulation of tumour necrosis factor receptor expression on neutrophils by arachidonic acid and other long chain fatty acids.
… effects of AA are not sensitive to the action of inhibitors of the cyclooxygenases and lipoxygenases. Using chemical inhibitors of intracellular signaling pathways, we demonstrate that the effect of AA on TNFRI is very sensitive to GFI09203X, PD098059, AACOCF3 and wortmannin, showing a role for …
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Melhoria do cálculo da temperatura inicial de aparecimento de cristais (TIAC) para petróleo com abordagens de modelagem termodinâmica simples
… with methods such as heat treatment and use of chemical inhibitors, for example, which are used to prevent the precipitation of wax. Therefore, it is necessary to specify the conditions under which precipitation can occur as a function of pressure, temperature and oil composition. Despite all …
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The role of reactive nitrogen species and aged garlic extract on platelet function
… along with the presence of specific inhibitors inhibited platelet aggregation independently of cGMP. Experimentation using chemical inhibitors also displayed erratic results in the presence of high concentrations of AGE, indicating that AGE was influencing the binding of such …
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E-cadherin mechanotransduction beyond cell-cell junctions
… Results presented in this thesis identified biochemical processes and signal transduction pathways in cadherin-based mechanotransduction. In this thesis, I investigated the role of E-cadherin in mechanotransduction, using modified Magnetic Twisting Cytometry (MTC) and Traction Force Microscopy …
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West Nile virus versus the host cell: Identification of host factors that modulate infection
… IFN compared to wild type cells. Additionally, chemical inhibition of PKR activity or post-translational gene silencing of PKR expression severely impaired WNV-induced IFN production, suggesting that PKR is critical for the induction of IFN following WNV infection. Further analysis suggested …
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Small Molecules as Probes for Cell Division and Intracellular Transport
… processes. Phenotype-based screens with chemical libraries have been used to identify such inhibitors. However, probes for most proteins are still not available, and the requirements on compound collections to yield such probes are not well understood. Here I present two approaches to …
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Molecular mechanisms involved in the anticancer activity of BISPMB in oesophageal cancer cells
… However, inhibition of JNK and p38 MAPK by chemical inhibitors, SP600125 and SB 203580 respectively, had no effect on bisPMB antiproliferative activity against WHCO1 cells. On the other hand, inhibition of ERK1/2 MAPK by U0126 enhanced the anti-proliferative effect of bisPMB in WHCO1 cells. …
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Influence of salicylate and abscisic acid on the resisitance of tomato to biotrophic and necrotrophic pathogens
… against pathogenes by putting up physical and biochemical barriers through processes involving hormone-mediated signalling. The plant defence hormone, Salicylic acid (SA), was tested for its role in the response of tomato and tobacco to a necrotroph, Botrytis cinerea and a biotroph, Oidium …
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Roles of the ING1 Epigenetic Regulator in Breast Cancer
… dysregulating epigenetic pathways with different chemical inhibitors could show synergistic effects with ING1 on killing cancer cells. We tested whether ING1 could synergize better with chemotherapeutics that target the same epigenetic mechanism or a different epigenetic mechanism. Combination …
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