Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Chemical imaging"”.
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Discrete frequency chemical imaging with stimulated Raman scattering microscopy
Chemical imaging, the process of using chemically-specific label-free light-matter interactions as a contrast mechanism for imaging or microscopy, is a powerful set of tools for performing investigations where the distribution of chemical constituents within a specimen is of importance. This can …
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Reagents for infrared chemical imaging of fingerprints on difficult surfaces
… such surfaces, Fourier transform infrared (FTIR) chemical imaging can provide superior results. FTIR chemical imaging involves the simultaneous collection of thousands of mid-infrared spectra across a sample using a focal plane array (FPA) detector. This allows for the collection of chemically …
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Quantitative chemical imaging: A top-down systems pathology approach to predict colon cancer patient survival
… tissue microarrays using infrared spectroscopic imaging. We developed supervised classification algorithms that were used to reliably segment colon tissue into histological components, including differentiation of normal and desmoplastic stroma. Thus, infrared spectroscopic imaging enabled us to …
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Benthic mineralization and microscale heterogeneity
… microscale heterogeneity affecting the biogeochemical functioning. Studies on microscale dynamics have been facilitated by recent developments of high resolution sensors for 2-dimensional chemical imaging. The presented<br/>work has contributed to this development by introducing a simple, …
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Advances in Stimulated Raman Scattering Microscopy via Deep Learning
… Raman scattering (SRS) microscopy is a powerful chemical imaging technique that acquires images based on the vibrational-spectral “fingerprints” of molecules within an imaged field of view often without the need for exogenous fluorophores or labels. SRS microscopy has found an established niche …
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Breast cancer diagnosis using Fourier transform infrared imaging and statistical learning
Cancer alters both the morphological and the biochemical properties of multiple cell types in a tissue. Generally, the morphology of epithelial cells is practically used for routine disease diagnoses. Current histopathological diagnosis involves manual interpretation of stained images for patient …
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Applying Mechanistic Understanding of Optical Absorption and Scattering Phenomena to Enhance the Spectroscopic Analyses of Pharmaceutical Materials
… applications.</p><p> Near-Infrared (NIR) chemical imaging based spatially-resolved spectroscopy was used to measure radially-diffused reflectance on pharmaceutical materials. A Monte Carlo simulation based partial least square (PLS) model was constructed to determine the absorption and …
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Molecular imaging with mass spectrometry: instrumental and methodological advances for biological applications
Mass spectrometry imaging (MSI) is an analytical technique providing a unique combination of capabilities: label-free, non-targeted, and highly multiplex detection and imaging of chemical species ranging in mass from single protons to large proteins exceeding 100 kDa, identifiable by mass and …
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Systems pathology: a bottom-up approach for understanding fibroblast-epithelial interactions in breast cancer
… of disease in tumor biopsies using an emerging chemical imaging technology. It has been described extensively that the tumor microenvironment, or stroma, can promote or suppress cancer phenotypes in many tissues. We hypothesized that interaction with fibroblasts, the predominant cell type found …
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Use of fourier transform- infrared spectroscopic imaging as a tool for understanding early molecular events driving breast cancer progression
… Fourier Transform infrared (FT-IR) spectroscopic imaging. Fibroblasts were stimulated using the growth factor TGFβ1, co-culture with MCF-7 tumorigenic breast epithelial cells, and co-culture with MCF10A normal breast epithelial cells in trans-well co-culture and also three-dimensional cell …
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Multi-Material Discrimination Using Photon Counting Spectral Computed Tomography
… applications in many areas including biomedical imaging, defense and security, geophysical imaging of rock composition and in materials and chemical imaging. Dual or multi-kVp x-ray exposure when using an energy-integrating detector has been proposed and demonstrated in the past for biomedical …
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Development of experimental and instrumental systems to study biological systems
… over traditional Raman instrumentation for rapid chemical imaging. While the MHI can reproduce the functionality of a traditional Raman spectrometer, its true speed advantage is realized after pre-training on known sample components. The MHI makes use of a spatial light modulator as a programmable …
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Discrete-frequency infrared imaging with a quantum cascade laser and diffuse optical Raman tomography: methods toward improving clinically relevant label-free chemical contrast
Label-free chemical imaging provides the ability to probe chemical structure without interference from dyes or other contrast agents which potentially alter the system being studied. Two emerging, non-invasive spectroscopic methods with significant potential include the use of quantum cascade laser …
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DEVELOPMENT AND APPLICATION OF CHEMOENZYMATIC TOOLS TO VISUALIZE MAMMALIAN PHOSPHOLIPASE D SIGNALING
Chemical imaging techniques have been instrumental in advancing our understanding of the spatiotemporal regulation of signal transduction pathways. Phospholipase D (PLD) enzymes are a critical signaling node responsible for production of the pleiotropic lipid second messenger phosphatidic acid via …
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Nanoscale infrared absorption imaging and tomography
Near-field spectroscopic imaging techniques offer a non-perturbative, molecular contrast for characterization of nanomaterials. While several techniques now provide nanoscale chemical maps by combining molecular vibrational spectroscopies with Atomic Force Microscopy (AFM), data are often …
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Label-free Photothermal Quantitative Phase Imaging with Spectral Modulation Interferometry
The photothermal effect is a way in which chemical contrast can be measured as an optical pathlength or phase change. When a chemical species in a sample absorbs optical energy at a particular wavelength, this absorption raises the temperature at these points in the sample via the photothermal …
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Identification and imaging different lipid species within phase-separated model membranes by integration of TOF-SIMS and principal component analysis
… ion mass spectrometry (TOF-SIMS) enables chemically imaging the distributions of various lipid species in model membranes. However, discriminating the TOF-SIMS spectra of structurally similar lipids is very difficult because the low mass fragment ions that are abundant in the spectra are …
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Method development for investigating chemical distributions in the nervous system using mass spectrometry imaging
Chemical heterogeneity is a fundamental property of multicellular organisms. Multiple classes of biomolecules exhibit complex spatial and temporal variations and interactions during different biological processes. One way to investigate this chemical diversity is to visualize biomolecule …
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Label-free tracking of photocatalysis on a single nanoparticle
… are exploited to catalyze industrially relevant chemical reactions. The successful design of these heterogeneous catalysts is hindered by our limited understanding of the chemical dynamics occurring in the working environment of a catalyst. An example is the limited mechanistic insights available …
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Pharmaceutical formulation development utilizing hot melt extrusion and other techniques for development of immediate and controlled release dosage forms
… using in vitro release testing and Near Infrared chemical imaging techniques. Manufactured films exhibited controlled release for ∼24 hrs with HPC exhibiting a more pronounced effect than RSPO. A correlation of 90% was obtained between polymer concentration on fifty percent and eighty percent drug …
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