Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Chemical Signaling"”.
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Chemical Signaling and Resource Use by African Elephants (Loxodonta Africana)
In polygynous, sexually dimorphic species like the African elephant, Loxodonta africana, resource distribution influences female dispersion, while the location of females shapes male dispersion. Human constriction of viable habitat has affected elephant movements and impact. Elephants travel in …
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BEYOND CHEMICAL SIGNALING: MECHANICAL FORCES AS DRIVERS OF MITOTIC AND METABOLIC CONTROL
… both have been extensively characterized biochemically and genetically, less is known about their mechanics and the central role played by mechanotransduction in their modulation. To elucidate these mechanisms, we deployed novel tools to exert mechanical stress on cells while monitoring their …
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Towards Bacteria Inspired Stochastic Control Strategies for Microrobotic Swarm Intelligence
… of many control algorithms. Localized chemical signaling within bacterial communities is used for directed movement and dynamic density measurements. Both individual and population scale models have been created to adequately model community dynamics. These dynamics, including directed …
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Chemical communication in a declining North American anuran amphibian, the northern leopard frog (lithobates pipiens)
Chemical signaling is known to be an important communication mechanism for amphibians. However, very few studies have directly investigated chemical signaling in anuran groups (frogs and toads), particularly adult anurans. Previous work has focused primarily on salamander and larval anuran …
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Force regulation in contractile cells by chemical and mechanical signaling
<p>Chemical and mechanical signaling are essential for physiological processes. Dysregu- lation of these signals can promote disease states by altering force generation. It is cru- cial that we understand how these signals affect force generation and the implication of that force in health and …
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Electrochemical and Magnetochemical Approaches for Neuronal Modulation
The development of tools to deliver chemical signals to specific neurons can enhance our understanding of chemical signaling in the nervous system and enable chemical therapies for neurological disorders. Existing technologies for chemical neuromodulation, including intracranial injection of …
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Genetic Regulation of Retinal Cells by Variation of Underlying Elastic Modulus
… changing the transcription of DNA. How this non-chemical signaling occurs, as well as which genes are affected in which cells and what stiffness levels trigger these changes, is now what needs to be investigated. We began working with a retinal cell line to see if these unique cells change …
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Exploring chemical communication and chemical heterogeneity in biological systems with mass spectrometry imaging
Chemical heterogeneity is present in all biological systems—whether caused by lipid regulation and expression between individual mammalian single cells or by dynamic chemical communication in bacterial communities. Mass spectrometry imaging (MSI) is an untargeted and unlabeled analytical tool that …
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Step-growth hydrogels crosslinked through grafted polypeptides enable nano- to macroscale synthetic extracellular matrix design
… and modulate biological, mechanical and chemical signaling, and 2) more closely mimic protein secondary structure found in the native extracellular matrix. A specific grafted N-carboxyanhydride polypeptide, poly(y-propargyl-L-glutamate) (PPLG), forms the foundation of this thesis. PPLG is …
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The Role of Host Hormones and Metabolites in the Regulation of Virulence in Enterohemorrhagic Escherichia coli (EHEC)
… an activator of the LEE PI. In addition to chemical signaling, nutrient availability plays an important role in bacterial gene regulation. We investigated the role that carbon nutrients play in the regulation of EHEC virulence. We showed that the LEE PI is activated under gluconeogenic …
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Regulation of Synaptic Vesicle Trafficking at Central Synapses
… are where electrical information is converted to chemical signaling, allowing for careful regulation of inter-neuronal communication in the brain. At presynaptic terminals, synaptic vesicles fuse with plasma membrane in response to electrical stimulation, followed by rapid retrieval to the …
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CHARACTERIZATION OF TRANSMEMBRANE PROTEIN 35 EXPRESSION: CONSIDERATIONS OF SEX AND OVARIAN HORMONES
… protein 35 (TMEM35), is believed to modulate chemical signaling within the nervous system. Notably, the TMEM35 protein is detectable in humans, non-human primates and rodents, suggesting a conserved and critical function. Despite this, the functions of TMEM35 are ill-defined in the nervous …
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Continuum Models of Collective Migration in Living Tissues
… deformations are coupled to and feed back onto chemical signaling.</p> <p>We begin in Chapter 1 with a brief review of cell migration at both the single-cell and many-cell levels, and of the experimental tools used to probe the mechanical properties of cells and tissues. In Chapter 2 we …
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Mass spectrometry-based identification and quantitation of endogenous peptides in complex biological matrices
In the brain, chemical signaling molecules transfer information from cell-to-cell to modulate mood, behavior, and physiological functions like metabolism and circadian rhythm. The research presented in this dissertation is focused on characterizing a specific class of signaling molecules, …
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Chimera Ligand for Pili and Lectin A Protein Controls Antibiotic-Promoted Biofilm Formation, Swarming Motility, Tolerance and Persister Formation by Pseudomonas aeruginosa
… demonstrated. This study suggests a potential chemical signaling approach to control multiple bacterial activities.</p>
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An engineering analysis of natural and biomimetic self-repair processes for solar energy harvesting
… of meta-stable thermodynamic states, and chemical signaling to switch between states. In this thesis, we mimic such regenerative mechanisms in an effort to develop biological light-harvesting devices with prolonged lifetimes. We demonstrate the first synthetic photoelectrochemical cell …
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The endocrinology and evolution of tropical social wasps: from casteless groups to high societies
… to be important for reproduction, dominance, chemical signaling (e.g., cuticular hydrocarbons (CHCs)) in queens while promoting the early onset of certain tasks in workers. Evidence for a similar mechanism in bees and ants suggests a dual function of JH was intact in the last common ancestor …
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Structural and Mechanistic Roles of Novel Chemical Ligands on Quorum Sensing Transcription Regulator SdiA in Enterohemorrhagic Escherichia coli
… behavior by sensing endogenously produced chemical signaling molecules, acyl-homoserine lactones (AHLs) [1]. However, some bacteria such as Escherichia coli (E. coli) do not produce AHLs and, therefore, their quorum sensing LuxR-type proteins are thought to be regulated by AHLs from other …
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Structural characterization of primary cilia using accelerated piezoelectrically driven STED nanoscopy
… They play essential roles in transduction of chemical and mechanical signals across the cell membrane. For example, primary cilia are able to transduce sonic hedgehog signals, necessary in embryonic development and adult stem cell functions. Recent work on primary cilia has demonstrated …
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