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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"Chemical Pathology"”.
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Digital chemical pathology
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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Conceptualising differentiated forms of knowledge : the Medical (MBChB) curriculum of the University of Cape Town
… (Biglan, 1973a,b). The two subjects chosen were Chemical Pathology and Culture, Psyche and Illness. Data were collected from course documentation, interviews with members of staff, and examples of assessments. These data were then analysed using Maton's legitimation code theory, which identifies …
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Determination of the frequency of four pathogenic variants causing inborn errors of metabolism in the western cape black population, using a multiplexed arms pcr approach
Background: Carrier frequency determination of repeatedly identified pathogenic variants causing inborn errors of metabolism will enable early diagnosis and treatment of illness, and counselling of prospective parents. Four single nucleotide variants (SNV) were identified in our black South African …
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Red blood cell pathophysiology : comparative and diagnostic aspects
Captive black rhinoceroses in the United States are threatened by three major clinical disorders. Among these, haemolytic anaemia ranks as the number one cause of death. The object of this study therefore was to determine the metabolic lesion responsible for the haemolytic anaemia. Since black …
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The prevalence of dysbetalipoproteinaemia in Ghanaian adults living in Accra
Background Dysbetalipoproteinaemia (dysβ) is a disorder characterised by elevated triglyceride-rich lipoprotein remnants leading to increased plasma levels of total cholesterol and triglyceride. Dysbetalipoproteinaemia is positively associated with premature cardiovascular disease. In several …
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Using urinary MCP-1 and TWEAK to assess disease activity in a cohort of South African patients with lupus nephritis
Background: Renal involvement is common in systemic lupus erythematosus (SLE) and can lead to chronic kidney disease (CKD). Diagnosis of lupus nephritis (LN) is dependent on renal biopsy. Due to its invasiveness, repeat renal biopsy for monitoring disease activity is not recommended, thus creating …
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DNA analysis of Ornithine Transcarbamylase (OTC) deficiency in South African patients
… nature and due to infective processes or liver pathology/immaturity, a significant number are due to defects in enzymes of the urea cycle. This cycle has evolved to cope with waste nitrogen disposal and the de novo synthesis of arginine. There are five distinct enzymatic steps in the urea cycle, …
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Molecular phylogenetics and conservation aspects of antelopes
This thesis concerns the molecular phylogenetics of three tribes of the family Bovidae, the Antilopini, Neotragini, and Tragelaphini. None of these tribes have been studied extensively with molecular techniques. The tribe Antilopini is one of the most speciose tribes (it includes 6 genera with 20 …
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Modelling neuroimmune interactions using organotypic slice cultures
Tuberculosis predominantly manifests in the form of a pulmonary infection, but may spread out into other parts of the body and is then referred to as extrapulmonary tuberculosis (EPTB). One form of EPTB is an infection of the central nervous system (brain & spinal cord), CNS-TB. Although CNS-TB is …
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A mutational analysis of the roles of cytoplasmic domains of the gonadotropin-releasing hormone receptor in coupling and internalization
The G protein-coupled receptor (GPCR) family is the largest group of homologous proteins in the human genome. GPCRs are of prime physiological and medical importance as the actions of a wide range of hormones and drugs are mediated by these receptors. The gonadotropin-releasing hormone (GnRH) …
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Systematic relationships in southern African Francolins as determined from mitochondrial DNA
The Francolins constitute the largest genus in the Galliform family Phasianidae. There is little accord concerning the taxonomic classification of its members. In the past, information on this group has been provided by morphological and palaeontological evidence. An investigation into the …
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The role of TNP-Nucleotides, LYS492 and CA²⁺chelators in the skeletal muscle sarcoplasmic reticulum CA²⁺atpase cycle
In the first part of this study, the kinetics of decay of TNP-nucleotide superfluorescence was investigated with a view to understanding the role of nucleotides and Lys492 in later steps in the catalytic cycle of the skeletal muscle Ca²⁺ATPase. It has been found previously, and verified here, that …
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Quantification of genetic variation on Island-breeding populations of Procellariiformes : an assessment of the impact of the longline fishing industry on seabirds
The number of albatrosses that are killed on longlines in the Southern ocean is conservatively estimated to be 44 000 birds per annum. These numbers are biologically significant since albatrosses are a prime example of an extreme K-selected species. Ongoing long line fishing in the Southern ocean …
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Whole Blood Mitochondrial DNA Depletion in Human Immunodeficiency Virus-Infected Children
Background: Nucleoside reverse transcriptase inhibitors (NRTIs) interfere with mitochondrial DNA polymerase gamma causing significant toxic effects, including fatal lactic acidosis. Little is known about mitochondrial DNA (mtDNA) in human immunodeficiency virus (HIV) infected children who face a …
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Properties of the non-catalytic nucleotide site of the Ca²⁺-ATPase of sarcoplasmic reticulum
Properties of the regulatory nucleotide binding site of the Ca²⁺-ATPase of skeletal muscle sarcoplasmic reticulum have been investigated. Previously, several lines of evidence have indicated the existence of both catalytic and regulatory nucleotide binding sites on the same polypeptide species. The …
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A study of the pathogenesis of fetal damage caused by ethanol in the experimental mouse
In an attempt to determine mechanisms of certain aspects of ethanol- induced fetal damage, I have established a mouse model of the fetal alcohol syndrome based on the work of Chernoff (1977), using inbred C3H mice. Ethanol or its metabolite, acetaldehyde, was administered to female mice prior to …
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Apolipoprotein E variants, plasma lipids, lipoproteins and dysApolipoprotein E variants, plasma lipids, lipoproteins and dysβLipoproteinaemia during pregnancy in Zimbabwean women.
This study of pregnant women in Zimbabwe therefore set itself the following aims: To describe lipid and lipoproteins during and after pregnancy, To examine the prevalence of apoE variants, To evaluate dysβlipoproteinaemia in pregnancy, The correlation between dysβplipoproteinaemia and the apoE …
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Membrane reconstitution studies on the irreversibility of inactivation of sarcoplasmic reticulum of rabbit skeletal muscle
Mild acid treatment or incubation in the presence of Ethylene glycol bis (β-aminoethyl ether) - N,N' - tetraacetic acid inactivates calcium transport by sarcoplasmic reticulum membranes but does not inhibit calcium stimulated ATPase activity. This inactivation is apparently irreversible. The …
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Properties of the nucleotide binding sites of the Ca²⁺-ATPase of sarcoplasmic reticulum
Properties of the nucleotide binding site of the Ca²⁺-ATPase of skeletal muscle sarcoplasmic reticulum have been investigated. The study centred around interaction of the high affinity ATP analog, 2'-3'-0-(2,4,6-trinitrophenyl)adenosine 5'-triphosphate, (TNP-ATP), with the Ca²⁺-ATPase. Defined …
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Cooling rates of dummies under various degrees of air humidity, wind speed and air temperature
Henssge observed that even a slight but permanent air movement accelerates cooling of a naked body significantly. However in those experimental studies the rate of air movement was not quantified. Today Henssge’s Nomogram method of thermometric thanatochronometry (mathematic estimation of the …
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