Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"Chelators"”.
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Ferrocenic metal chelators : synthesis, biological and electrochemical studies
… of P. falciparum. A series of novel iron chelators were designed and synthesized based on thiosemicarbazone and/or ferrocenyl moieties. The novel compounds were characterized by NMR, infrared (IR) and mass spectroscopy as well as microanalysis and subjected to biological evaluation. All …
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A novel and rational approach towards designing aluminium chelators
… model for evaluating the influence of potential chelators on the passage of aluminium into cells. Preliminary studies involving the Cambridge Structural Database (CSD) identified that Al prefers binding to bidentate ligands in a 3:1 manner, whereby oxygen was the exclusive donating atom. …
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The good without the bad: Selective chelators for beryllium encapsulation
Beryllium is an indispensable metal. Its unmatched combination of unique properties such as extreme strength, low density and high machinability has made it vital in the automotive, nuclear, space, medical, defence sectors and other consumer industries. However, beryllium is considered the most …
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Leveraging copper chelators as targeted therapy for BRAFV600E mutant thyroid cancer
… Cu chelator tetrathiomolybdate (TM). Cu chelators have been in use for decades in patients with Wilson’s Disease, a disease of Cu accumulation. Unlike current BRAF and MEK inhibitors, Cu chelators can be well tolerated for decades with few side effects, and thus may find use in long-term …
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Prevention of bacterial growth in platelet products via inclusion of iron chelators
… Thus we hypothesize that the inclusion of iron chelators will bind and remove iron, thereby inhibiting bacterial growth in both culture medium and platelet concentrates. Additionally, we hypothesize that residual red blood cells (RBCs) in platelet units may contribute bioavailable iron that …
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Separation and Characterization of Reconstituted Skim Milk Powder Treated with Mineral Chelators
… of separating milk treated with calcium chelators using various separation techniques to evaluate the individual casein fractions of this disrupted system. Four separation methods (ultracentrifugation, membrane filtration, heat coagulation, and coagulation based on pH) were employed to …
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Development of amyloid beta binding bifunctional chelators for diagnosis of Alzheimer’s disease
… we designed a series of diester bifunctional chelators (BFCs) and characterize them via a series of biophysical experiments, including ex vivo transgenic mouse brain section staining and autoradiography studies for assessment of amyloid plaques targeting ability, along with 64Cu radiolabeling …
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Crocidolite dissolution in the presence of Fe chelators: implications for mineral-induced disease
… Fe removed from the fiber surface by molecular chelators present in the body can promote a series of reactions that yield the hydroxyl radicals (•OH) which are known to cause DNA damage. This breakdown of DNA may be part of the mechanism for crocidolite-induced pathogenesis. X-ray photoelectron …
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The role of TNP-Nucleotides, LYS492 and CA²⁺chelators in the skeletal muscle sarcoplasmic reticulum CA²⁺atpase cycle
… it was shown that addition of small amounts of chelators EGTA, EDTA, BAPTA, DTPA, HEDTA and NTA to a Ca²⁺ transport assay in which the free Ca²⁺ concentration is monitored by Fluo-3 causes the Ca²⁺ATPase to pump to apparently lower levels as seen in the [Ca²⁺] lim fluorescence. Addition of …
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Syntheses of mono- and diamide cross -bridged cyclens and syntheses of bifunctional chelators based upon cross -bridged tetraamine macrocycles
… macrocycles are promising bifunctional chelators (BFC). Improved synthesis of one BFC (36) is presented, alternative synthesis of one BFC (39) is also presented, the synthesis of a precursor of one BFC (42), the attempted syntheses of four BFCs (40, 41, 43 and 44) and the syntheses of …
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Design and synthesis of novel compounds as fatty acids binding protein inhibitors and as gallium-68 chelators for positron emission tomography
Finding new small molecules targets as well as improving the diagnosis methodologies are two of the most important areas in which the researchers are spending efforts to improve our arsenal to fight cancer and other diseases. In this thesis, two different chapters are discussed. In the first one, …
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Evaluation of radiolabelled hynic-salmon calcitonin analogues as imaging agents for multiple myeloma and characterisation of novel hynic derivatives as chelators for technetium
… of novel hydrazinonicotinate (hynic) chelators. Following chemical characterisation in vitro stabilities of the radiopeptides were assessed on incubation in human serum. In vitro uptake studies in CTR+ MCF-7 cells confirmed that the Tc-99m labelled sCTLys18-hynic-TFA and …
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Influence of Chelating Agents on Proteolysis of Micellar Casein Slurries
… of this research was to analyze the effect of Ca chelators on the proteolytic activity of rennet during ripening of a micellar casein slurry. This research was divided in two phases. During the first phase, preliminary studies were performed to understand the behavior of rennet and the milk system …
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Novel MRI Contrast Agents Based on Functional DNA and Nanomaterial Conjugates for Biomedical Applications
… in water. At the same time, we have shown that chelators of inorganic mercury can be encapsulated in liposomes and released upon mercury detection.
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Presence and Role of Acanthamoeba in Wound Infections
… microorganisms to grow is iron. The role of iron chelators, including deferiprone and selected novel compounds based on hydroxyl pyridine moiety, was studied. Findings revealed that all novel iron chelators have an antimicrobial activity against both bacteria. In addition, all novel iron chelators …
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Physiology and Biochemistry of Lead Accumulation in Sesbania Drummondii
… grown in the presence of Pb and synthetic chelators in soil and 3) the expression of antioxidant enzymes in S. drummondii seedlings exposed to Pb and synthetic chelators in aqueous media. In the first study, Sesbania drummondii plants were grown in soil containing 0-10 g/kg Pb(N03)2 for 0-4 …
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Macromolecular Reactions and Sensory Perception at the Air-Water-Human Interface
… for the metallic flavor. Antioxidants and chelators were investigated to study prevention of lipid oxidation and, chelators were determined to be more effective. Oral epithelial cell cultures were developed as a model for oral cavity to further investigate lipid oxidation and effectiveness …
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Prediction of Physicochemical Properties For Fe3+ Chelating Agents
… have also been shown to be useful therapeutic chelators, demonstrating the essential affinity and selectivity for Fe3+ along with good oral activity. Deferiprone, a typical HPO, has emerged as a prominent therapeutic, able to remove accumulated excess iron from the heart and mitochondria. …
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