Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Chek1"”.
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Identifying New Genes for Inherited Breast Cancer by Exome Sequencing
… breast and ovarian cancer were detected in ATR, CHEK1, and GEN1, each in one of the 54 families. ATR is recruited to sites of DNA damage; ATR phosphorylates CHEK1 in response to DNA damage, leading to a halt in cell cycle progression; GEN1 is an endonuclease that resolves Holliday junctions. Like …
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Host Modulators of the Death Response to Influenza A Infection
… inhibition of representative targets, RGGT and CHEK1, resulted in significant protection against infection of human epithelial cells by the A/WS/33 virus. In addition, chemical inhibition of RGGT partially protected against H5N1 and the 2009 H1N1 pandemic strain. The observations reported here …
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Deciphering The Role of miR-506 in Ovarian Cancer Drug Sensitivity
… damage repair (DDR) pathway, like RAD51, RAD17, CHEK1 and WEE1 and I concentrated on genes not previously studied in EOC. I validated RAD17 as a direct target of miR-506 and identified the miR-506-RAD17 axis as relevant in chemosensitising EOC cells to different treatments. I demonstrated that …
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Immunohistochemical and molecular studies on ovarian cancer progression and prognosis
… of poor prognosis in EOC were identified, i.e. Chek1, Chek2 and minichromosome maintenance complex component 3 (MCM3). Paper III provides a first description of expression of the Dachshund 2 (DACH2) protein in any form of human cancer, after its identification in the Human Protein Atlas portal. …
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Axis of placental ageing in adverse pregnancy outcomes
… expression of senescence associated genes CHEK1, PCNA, PTEN, CDKN2A, CCNB-1 was significantly upregulated in PE, while TBX-2, PCNA, ATM and CCNB-1 expression were significantly decreased in IUGR compared to controls. Moreover, placental p16 protein expression was significantly decreased in …