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Showing 1 to 2 of 2 for “"Checkpoints, Mitotic"”.
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Generating the Spindle Assembly Checkpoint Signal at the Kinetochore
… containing BubR1 and Bub3 has been purified from mitotic human cells. BubR1 directly interacts with Cdc20 and inhibits the activity of APC in vitro,much more efficiently than Mad2. Surprisingly, the kinase activity of BubR1 or association with Bub3 is not required for the inhibition of APCCdc20. …
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Generating the Spindle Assembly Checkpoint Signal at the Kinetochore
… containing BubR1 and Bub3 has been purified from mitotic human cells. BubR1 directly interacts with Cdc20 and inhibits the activity of APC in vitro,much more efficiently than Mad2. Surprisingly, the kinase activity of BubR1 or association with Bub3 is not required for the inhibition of APCCdc20. …