Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Checkpoint kinases"”.
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Cell cycle checkpoints and checkpoint kinases in the apicomplexan parasites Plasmodium and Toxoplasma
… repair mechanisms and particularly cell cycle checkpoint mechanisms in *P. falciparum* are not well characterised. A greater understanding of these is required, especially as artemisinin- resistant parasites have a dormancy phenotype that resembles a cell cycle checkpoint. Elucidating these …
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Investigating Checkpoint Kinases 1/2 As Novel Therapeutic Targets In Head and Neck Squamous Cell Carcinoma
… lethal strategy through targeted inhibition of checkpoint kinases Chk1/2 leads to cisplatin sensitization of p53-deficient cells through induction of mitotic death. Serendipitously, we also found out that a significant subset (roughly 20%) of HNSCC cell lines are acutely sensitive to single …
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Elucidation and characterisation of checkpoint kinase interactions with the replisome
… mechanism called the DNA replication checkpoint (DRC) which ensures that replication is successful, even under conditions which perturb replication (also called replication stress). Checkpoint kinases are the major actor of DRC activation, coordinating multiple cellular events with …
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Deciphering The Role of miR-506 in Ovarian Cancer Drug Sensitivity
… the signalling cascade responsible for G2/M checkpoint activation upon DNA damage insults. This behaviour, recapitulating a BRCAness phenotype, would allow propagation of cells with unrepaired DNA damage with the subsequent sensitisation to DNA damaging drugs. Furthermore, miR-506 expression, …
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Consequences of partial chromosome re-replication in mammalian cells
… re-licensing in G2. Inhibition of cell cycle checkpoints in<br/>cells lacking geminin promotes progression through mitosis without detectable<br/>levels of re-replication. Checkpoint kinases thereby amplify re-replication into an<br/>all-or-nothing response by delaying geminin depleted cells …
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Examining the Regulation of Cell Division by the Spindle Assembly Checkpoint
… mechanism called the spindle assembly checkpoint (SAC) inhibits chromosome segregation before all chromosomes are correctly attached (bi-oriented) on the microtubule spindle to prevent segregation errors that may lead to chromosomal instability and cell death. In this thesis, I have …
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RADIOSENSITIZING EFFECTS OF THROMBIN PEPTIDE TP508 ON MEDULLOBLASTOMA CANCER STEM CELLS
… and by downregulating the activation of checkpoint kinases necessary for cell cycle arrest and repair. A strong understanding of the mechanisms by which TP508 exerts its effects on CSCs will allow for the development of this peptide as a novel therapeutic to target brain cancers, improve …
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Identification and characterization of novel genes involved in DNA double strand break repair process in the yeast Saccharomyces cerevisiae
… in the NHEJ process through interaction with checkpoint kinases Rad53 and Chk1. We also propose a novel role for yeast uncharacterized ORF HUR1, in NHEJ pathway through its association with Nej1. We also report that BUB1/BUB2 may affect the efficiency of NHEJ by limiting cell cycle …
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Novel Roles of Replication Protein A Phosphorylation in Cellular Response to DNA Damage
… including replication, recombination, DNA damage checkpoints and signaling, as well as all DNA repair pathways. This project presents 2 novel roles of RPA in the cellular response to DNA damage. The first elucidates the regulation of RPA and p53 interaction by DNA-dependent protein kinase …
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PARKIN, BLM AND EXO1: INVOLVEMENT IN POST-NER ACTIVITY IN NON-REPLICATING CELLS
… trigger the activation of the DNA damage checkpoint signaling cascade and can potentially lead to the generation of toxic Double-Strand Breaks (DSB). We analyzed the response of murine neurons to the bulky lesions inducing agent BPDE, and we found indeed that the compound was able to …