Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Checkpoint Inhibitors"”.
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Immunotoxin Monotherapy and Combinatorial Therapy With Immune Checkpoint Inhibitors for Malignant Brain Tumors
… previous studies have demonstrated that immune checkpoint inhibitors have a robust anti-tumor efficacy by augmenting the T cell response to the tumor cells. Thus, immune checkpoint inhibitors were combined with D2C7-IT in order to enhance the immunotoxin-induced anti-tumor immune response to …
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Increased Risk of Cutaneous Immune-Related Adverse Events in Patients Treated with Talimogene Laherparepvec and Immune Checkpoint Inhibitors: A Multi-Hospital Cohort Study
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Discovery of Anti-CD47 Peptides for Cancer Immunotherapy and CD47-mimicking Peptides That Inhibit Phagocytic Clearance of Nanoparticles
… as a standard pillar of cancer treatment. Immune checkpoint inhibitors that are currently available target the adaptive immune system, generating T-cell antitumor responses. As critical innate immune cells, macrophages play important roles in homeostasis, preventing pathogen invasion, eliminating …
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Endocrine Effects of Cancer Chemotherapy
… antibiotics, targeted therapies, and immune checkpoint inhibitors—affect the endocrine system. It examines chemotherapy-induced dysfunctions in key endocrine glands, including the hypothalamus-pituitary axis, thyroid, adrenal glands, gonads, and pancreas. Special attention is given to …
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Interpretable Modeling of Immunotherapy Response Factors
… and B-cell lymphoma. A type of immunotherapy, checkpoint inhibitors work by blocking the ability of cancer cells to evade immune system detection. However, not all patients respond to checkpoint inhibitors, even those with the same tumor types, and the complexity of biological networks and …
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Imaging Biomarkers of Response to Immune Checkpoint Inhibition in Melanoma
Immune checkpoint inhibition using monoclonal antibodies targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed cell death receptor-1 (PD-1) to enhance cytotoxic T-lymphocyte response against tumours has been used in the management of several malignancies including metastatic melanoma. …
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Exercise as an adjunct therapy in melanoma patients undergoing checkpoint inhibitor therapy
… ± 13.6 years) with advanced melanoma receiving checkpoint inhibitors completed the 8-week single-group telehealth intervention. Intervention sessions were undertaken three times per week (24 sessions) and included supervised comprehensive balance, aerobic, and resistance exercises. The …
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Engineered Type 1 Conventional Dendritic Cell–Based Therapies for In Situ Cancer Immunization
Cancer immunotherapy, such as immune checkpoint inhibitors, Chimeric Antigen Receptor (CAR) T therapy, and cytokine therapy, have achieved successful improvement in extending survival in some patients. However, the immunosuppressive environment of solid tumors substantially compromises therapeutic …
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Establishment of recombinant antibody technologies allowing for the generation of SNAP-tag fusion proteins
… of all mAb based therapies currently used, are checkpoint inhibitors. In a balanced immune response, immune activation is counteracted with immunoregulatory pathways such as checkpoint inhibition. These negative regulatory pathways are necessary for maintaining tolerance and preventing …
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Biologically Interpretable Representation Learning for Mechanistic Insights into Cancer Immunotherapy Resistance
Resistance to immune checkpoint inhibitors (ICIs) remains a critical barrier to effective cancer therapy, driven by complex, multi-scale interactions that current biomarkers often fail to capture. This dissertation introduces the Biologically Disentangled Variational Autoencoder (BDVAE)—an …
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Micrornas Associated With Melanoma Inflammation and Response to Pd-1 Inhibition
… targeted agents and immunotherapies. Immune checkpoint inhibitors achieve T-cell mediated anti-tumor efficacy by blocking engagement of inhibitory checkpoints on T-cells to overcome immunosuppressive signals from tumor cells and the broader microenvironment. Despite these advances, there are …
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Single cell landscape of innate and adaptive immunity in metastatic melanoma treated with immunotherapy
Immune checkpoint inhibitors (ICIs) have revolutionized the care for cancer and extended survival for many patients. While ICIs have shown astonishing clinical benefits, less than 50% of patients experience a durable response. To find better biomarkers for ICI response and understand the diverse …
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Investigating the Mechanisms of Resistance to Dual PI3K/MTOR Inhibitor in PIK3CA Mutant Basal Like Bladder Cancer
… To date, targeted therapies, except for immune checkpoint inhibitors have not been shown to be effective in the management of this disease, where conventional chemotherapy (i.e. cisplatin) continues to be the standard of care. Therefore, the challenge lies in identifying key molecular events …
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The Role of Ganglioside GD2 and GD3 Synthase (ST8SIA1) in the Regulation of Immune Suppression in Breast Cancer
… that GD3S expression associates with immune checkpoint inhibitors and its elevated expression in primary breast tumors causes a reduced immune cell infiltration into the tumors. Additionally, we have observed that GD3S regulates macrophage-mediated phagocytosis, NK cell-mediated killing and T …
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Understanding and Targeting The Immunosuppressive Tumor Microenvironment
<p>Immune checkpoint inhibitors (ICIs), such as anti-PD1/PD-L1 and anti-CTLA-4, have shown impressive antitumor efficacy by improving the activity of T cells. While these inhibitors work in many patients with various cancer types, they have minimal or no effect in many more patients. Mounting …
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Identification Of Effective New Drugs Combinations Exploiting The Ability Of trabectedin To Modulate Transcription
… that its activity could be increased by checkpoint inhibitors. The studies performed on the combination of trabectedin and the WEE1 inhibitor, AZD-1775, have shown that the inhibition of WEE1 enhances the trabectedin activity, thus the combination is synergic. Since trabectedin affects …
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Efficacy of novel immunotherapeutic strategies targeting L1CAM in pancreatic cancer
… (MYC-I) altered the presentation of immune checkpoint proteins at the cell surface of different immune cell populations including monocytes and T cells suggesting a more anti-inflammatory phenotype. These findings suggest that a combinatory treatment of L1CAMxCD3-bAB and immune checkpoint …
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Systems immunology frameworks link multicellular immune perturbation phenotypes and setpoints to response outcomes
… a cohort of cancer patients treated with immune checkpoint inhibitors. In this work, we identify multicellular baseline setpoints linked to development of immune related adverse events after treatment which are uncoupled from the phenotypes induced by treatment. Together, these approaches help …
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Modulation of the tumor microenvironment by the CXCR4 antagonist AMD3100 in pancreatic and colorectal adenocarcinoma
Immunotherapy with checkpoint inhibitors has not been effective thus far in patients with micro-satellite stable pancreatic ductal adenocarcinoma (PDAC), which suggests an immunosuppressive mechanism operates within the tumour microenvironment (TME) of PDAC. In the KRasG12D; p53R172H; Pdx1-Cre …
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