Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 523 for “"Checkpoint"”.
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A semi-blocking checkpoint protocol to minimize checkpoint overhead
… fault tolerance strategy. Double in memory/disk checkpointing is a production fault tolerance strategy in Charm++ runtime system. Each node will store one copy of its checkpoint in its own memory or disk as a local checkpoint and another copy in other node’s memory or disk as a global checkpoint. …
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Self-tuning data exploration checkpoint
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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Safeguard of Mitosis: The Spindle Checkpoint
… attachment is under surveillance by the spindle checkpoint to ensure the fidelity of chromosome segregation. Defects in the checkpoint could lead to aneuploidy, which has been implicated in cancers, birth defects, and other human diseases. In presence of kinetochores that are not attached or …
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Histone H3 K4 Methylation Regulates The Spindle Assembly Checkpoint Through Direct Binding of Multiple Checkpoint Components and Cdc20
… regulating mitosis through the Spindle Assembly Checkpoint. The Spindle Assembly Checkpoint ensures duplicated chromosomes are segregated correctly and each daughter cell receives one full copy of the genome. Our data show <em>SET1 </em>mutants and histone H3K4 mutants display a resistance to the …
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Keeping checkpoint/restart viable for exascale systems
… techniques to ensure progress across faults like checkpoint/restart, the dominant fault tolerance mechanism for the last 25 years, are increasingly problematic at the scales of future systems due to their excessive overheads. In this work, we evaluate a number of techniques to decrease the …
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Meiotic Dna Re-Replication And The Recombination Checkpoint
… required for the meiotic recombination checkpoint. Therefore, indicating that induction of the pachytene checkpoint by a gene deletion of <em>DMC1</em> was responsible for meiotic DNA re-replication. The downstream targets of the meiotic recombination checkpoint, Ndt80, Sum1, and Swe1, …
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Mathematical Modeling Reveals That G2/M Checkpoint Override
<p>Cell cycle checkpoints determine whether cells meet requirements to progress through the next stage. In response to DNA damage, how cells activate checkpoints have been well studied, but little is known about checkpoint deactivation (recovery), which directly impacts on cell fate. In tumor …
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Generating the Spindle Assembly Checkpoint Signal at the Kinetochore
… a surveillance mechanism termed Spindle assembly checkpoint that senses the lack of tension/attachment on the kinetochores and consequently blocks anaphase onset by inhibiting an E3 ubiquitin ligase called anaphase-promoting complex. The roles of two kinases- BubR1 and Mps1, implicated in spindle …
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Generating the Spindle Assembly Checkpoint Signal at the Kinetochore
… a surveillance mechanism termed Spindle assembly checkpoint that senses the lack of tension/attachment on the kinetochores and consequently blocks anaphase onset by inhibiting an E3 ubiquitin ligase called anaphase-promoting complex. The roles of two kinases- BubR1 and Mps1, implicated in spindle …
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Functions of RTF2 in DNA Replication and Checkpoint Control
… RTF2-deficient cells bypass the intrinsic S/G2 checkpoint and prematurely accumulate mitotic markers while replication proceeds. To understand the mechanism of checkpoint bypass in these cells, we performed an in silico protein interaction screen using AlphaFold-Multimer. We identified a …
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DNA stress checkpoint control in Arabidopsis thaliana by WEE1
… control mechanism is utilized by the DNA damage checkpoint to induce a cell cycle arrest upon DNA stress. In plants, a homolog of the WEE1 gene is present and is also responsible for phosphorylation of CDKs, although only during DNA damage. Plants that not contain a functional WEE1 gene develop …
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Determining stromal evolution in response to immune checkpoint inhibition
… to the clinic with the discovery of immune checkpoint inhibitors (ICIs) which reactivate anti-tumour T cells. However, their rapid translation into front-line treatment has left a number of the fundamental mechanisms of action of the drugs underexplored. One outstanding question is why a …
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Molecular Mechanisms of Mitotic Checkpoint Complex Assembly onto Kinetochores
… attachments, the spindle assembly checkpoint (SAC), activates the mitotic checkpoint complex (MCC), to inhibit the E3 ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C). Inhibition of the APC/C then delays premature chromosome segregation by preventing APC/C-mediated …
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Regulation of the spindle checkpoint by Mad2 binding proteins
The spindle checkpoint ensures the fidelity of chromosome segregation by delaying anaphase until all sister chromatids form proper bipolar attachments to the mitotic spindle. Spindle checkpoint proteins localize to unattached or maloriented kinetochores in mitosis and generate a signal that …
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Identification of TICRR, a novel checkpoint and replication regulator
… cells have evolved surveillance mechanisms, or checkpoints, that protect the cells from DNA lesions. Understanding the molecular mechanisms by which checkpoints act is of clinical relevance, since mutations in checkpoint components are often associated with human developmental disorders and …
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A semantic checkpoint framework for enabling runtime-reconfigurable applications
… applications through the use of semantic checkpointing. We view applications here as a collection of inter-connected components, and reconfigurations as the reconstitution of components that make up an application. By checkpointing only values that are deemed to be of semantic …
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RNA Knockdown of the Immune Checkpoint VISTA Promotes Tumor Regression
… and unique opportunity for synergism with checkpoint blockade therapy due to its upregulation on tumor infiltrating MDSCs and TAMs suggesting that therapeutic approaches that effectively reduce VISTA protein (e.g., VISTA ASOs) may occupy a distinct compartment to evolve into a novel therapy …
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Outcomes of Immune Checkpoint Inhibitor-Mediated Colitis: Multicenter Cohort Study
Immune checkpoint inhibitor (ICI)-mediated colitis (IMC) is a common and serious toxicity. Multiple reports have described the clinical presentation and course of IMC based on limited data. This was a collaborative effort from several cancer institutes to investigate features and outcomes of IMC. …
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Elucidation and characterisation of checkpoint kinase interactions with the replisome
… mechanism called the DNA replication checkpoint (DRC) which ensures that replication is successful, even under conditions which perturb replication (also called replication stress). Checkpoint kinases are the major actor of DRC activation, coordinating multiple cellular events with …
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