Global ETD Search

Single-molecule studies on the accessibility of chromatin : post-translational modifications and nucleosome remodeler CHD1

Quack, SalinaUniversität Ulm

ulm-diss Repository record for Single-molecule studies on the accessibility of chromatin : post-translational modifications and nucleosome remodeler CHD1 (opens in a new tab)

Structural Investigation of the Chromatin Remodeller Fun30

Faherty, JonathanUniversity of Dundee2016

… members Fun30 (Function Unknown Now 30) and Chd1 function as homodimers and monomers respectively and represent tractable systems for structural investigation in comparison to multi-subunit complexes. Here systems are described for expression of Fun30 and Chd1 protein fragments from …

dundee Repository record for Structural Investigation of the Chromatin Remodeller Fun30 (opens in a new tab)

Understanding and Targeting The Immunosuppressive Tumor Microenvironment

Cai, Li, <p>0000-0002-2160-5055</p>2023

… that MDSC recruitment can be regulated by CHD1-mediated IL6 secretion in PTEN- deficient PCa cells. Targeting the CHD1/IL-6 axis significantly decreased MDSC infiltration in TME and improved the efficacy of ICIs in multiple PTEN-deficient PCa mouse models.</p> <p>Another important aspect …

uthsc Repository record for Understanding and Targeting The Immunosuppressive Tumor Microenvironment (opens in a new tab)

Identification of Novel Prostate Cancer Subtypes Using Stem/Progenitor Cell Models

Rodrigues, Lindsey UlkusWake Forest University2014

Prostate cancer (CaP) is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths in American men. Despite earlier detection, CaP continues to be fatal in ~10% of cases and better treatments for patients with advanced disease are desperately needed. Understanding …

wfu Repository record for Identification of Novel Prostate Cancer Subtypes Using Stem/Progenitor Cell Models (opens in a new tab)

Identification of a conserved alternative mRNA splicing program that supports hepatic growth and maturation during development and regeneration

Bhate, AmrutaUniversity of Illinois at Urbana-Champaign2018

… mature hepatocyte markers like Cyp2b10, Alb and Chd1 and a persistent expression of fetal genes like Meg3 and Chd2. Histological analysis showed that ESRP2 KOs have a normal hepato-somatic index, but have smaller cells with increased number of mono- and bi-nucleated hepatocytes. Based on these …

uiuc Repository record for Identification of a conserved alternative mRNA splicing program that supports hepatic growth and maturation during development and regeneration (opens in a new tab)

Single molecule investigations into DNA replication, recombination and repair

Qiu, YupengUniversity of Illinois at Urbana-Champaign2015

Double-stranded DNA breaks (DSBs) is a principal cytotoxic damage that can be repaired by several well-known repair pathways. One of the most prominent routes is the homologous recombination (HR). The mechanism of repair has been studied primarily by biochemical analysis over the years. Recent …

uiuc Repository record for Single molecule investigations into DNA replication, recombination and repair (opens in a new tab)