Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Charybdotoxin"”.
-
Beeinflussung der Migration humaner neutrophiler Granulozyten durch Ca 2+-empfindliche K +-Kanäle (hIK1)
… spezifischen hIK1-Kanalblocker Clotrimazol und Charybdotoxin führten zu einer dosisabhängigen Verringerung der Migrationsgeschwindigkeit Neutrophiler. Eine Hemmung der hIK1-Kanäle mittels Clotrimazol und Charybdotoxin fürte zu einer signifikanten Zellschwellung. Die mittels Hypotonie erzwungene …
-
Zur Drucksensitivität der Kanalfunktion vestibulärer Haarzellen Typ II
… K+ current. These currents are inhibited by charybdotoxin, an inhibitor of Ca2+ dependent K+ channels. Furthermore cinnarizine is an inhibitor of voltage-gated Ca2+ currents in hair cells and is used as a drug in condition with vestibular vertigo. An aim of the presented experiments was to …
-
Activation of Ca<sup>2+</sup>-activated K<sup>+</sup> Channels and Cell Migration by Hepatocyte Growth Factor/Scatter Factor in Madin-Darby Canine Kidney Cells.
… MDCK-F cells depends on activation of a charybdotoxin (ChTX)-sensitive, volume-activated membrane K<sup>+</sup> current. Patch-clamp electrophysiology and transwell migration assays were used to study the effects of HGF/SF on membrane K<sup>+</sup> currents and cell migration in MDCK II …
-
Einfluß des Ca2+-sensitiven Kaliumkanals hIK1 auf die Migration humaner neutrophiler Granulozyten auf Fibronektin
… Blockade der Kaliumkanäle mit Clotrimazol und Charybdotoxin ergebenhatten. Nachdem ausgeschlossen wurde, dass Zellmorphologie oder –geschwindigkeit diesen Unterschied bedingten, spricht dies für einen matrixspezifischen „Crosstalk“ zwischen Adhäsionsmolekülen der Zelle und Untergrund. Die dabei …
-
Vascular action of glycine in hypertensive rat models
… K+ channel inhibitors, apamin and Tram-34/charybdotoxin. In contrast, intravenous administration of glycine evoked a fall in BP in normotensive Wistar-Kyoto (WKY) rats and an elevation of BP in spontaneously hypertensive rats (SHR), and in WKY rats subjected to chronic nitric oxide (NO) …
-
Relaxin: a new cardiovascular hormone in humans? Comparative potency and mechanisms of action
… (NOS) inhibitors and EDHF with apamin and charybdotoxin (potassium channel blockers) (n=7) had a curious effect causing the opposite action to that expected, by enhancing relaxin’s vasodilatory action. In patients not treated with an ACE inhibitor, we found that manipulation of nitric oxide …
-
Endozytose des Ca2+-sensitiven hIK1-Kanals in migrierenden MDCK-F-Zellen
… K+-Kanäle (IK1) durch das Skorpiongift Charybdotoxin wird die Migrationsfähigkeit von Zellen erheblich gestört. Da dies ein möglicher thera-peutischer Ansatzpunkt zur Malignitätsreduzierung von Tumoren durch Hemmung der Metastasierung sein könnte, galt es in dieser Arbeit, den …
-
Regulierung eines kalziumempfindlichen Kaliumkanals durch Proteinkinase C
… aktiviert. Der Kanal wird durch Barium, Charybdotoxin und Clotrimazol blockiert und durch 1-Ethyl-2-Benzimidazolon aktiviert. Die funktionellen und pharmakologischen Eigenschaften des klonierten cIK1 entsprechen damit denen des nativen Kanals aus MDCK-F-Zellen und stimmen mit denen …
-
Tissue injury and remodeling in rat hippocampal dentate gyrus following sodium-potassium-ATPase inhibition.
… features. The broad-spectrum K+ channel blocker, charybdotoxin is capable of significantly attenuating the neuronal damage associated with inhibition of the Na+, K+ pump, indicating that loss of intracellular K+ plays an important role in cell death associated with pump inhibition. (3) We describe …
-
Studies on preconditioning with adenosine, glutamate and ouabain in rat hippocampal slices
… Ouabain was also co-perfused in the presence of charybdotoxin, a blocker of large-conductance calcium activated potassium channels. It was observed that charybdotoxin enhanced the effect of ouabain upon the antidromic spikes. No changes were detected in HSP72 expression in the slices in response …
-
Interactions of insecticidal spider peptide neurotoxins with insect voltage- and neurotransmitter-gated ion channels
… selective BKCa blockers such as paxilline, charybdotoxin and iberiotoxin did not induce acute toxicity in insects. Furthermore, while ƙ-HXTX-Hv1c was found to prolong action potential repolarisation, increase spontaneous firing frequency and reduce spike afterhyperpolarisation, these results …