Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 208 for “"Chaperones"”.
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Microglial activation and regulation by secreted chaperones
… and LRPAP-1 are ubiquitously expressed protein chaperones that aid in protein folding and processing within the endoplasmic reticulum (ER). Both proteins might also be released into the extracellular space, but, if so, it is unclear whether and how they affect microglial functions when present …
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Energy Stress Causes Chaperones to Assemble Into Cytoplasmic Complexes
<p>The majority of proteins require molecular chaperones to assist their folding into tertiary and quaternary structures. Certain stresses can compromise the weak hydrophobic forces responsible for these structures and lead to protein unfolding, misfolding, and aggregation. Aggregates of proteins …
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Regulation of mammalian IRE1α: Co-chaperones and their importance
… inhibition establish BiP and its J-domain co-chaperones as key regulators of the UPR. This thesis also utilises the power of Cas9-CRISPR technology to introduce specific mutations into the endogenous IRE1α locus and to screen for derepressing IRE1α mutations. Via this methodology, two …
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Investigating the molecular mechanisms of chaperones involved in antigen presentation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Deciphering The Role of Hsp110 Chaperones In Diseases of Protein Misfolding
<p>Molecular chaperones maintain protein homeostasis (proteostasis) by ensuring the proper folding of polypeptides. Loss of proteostasis has been linked to the onset of numerous neurodegenerative disorders including Alzheimer’s, Parkinson’s, and Huntington’s disease. Hsp110 is a member of the Hsp70 …
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Stress-Induced Targeting of Molecular Chaperones In The Yeast Saccharomyces Cerevisiae
… (HSP) is induced, which act as molecular chaperones to assist in the repair or triage of unfolded proteins. The 90-kDa HSP (Hsp90) operates in the context of a multi-chaperone complex to promote the maturation of nuclear and cytoplasmic clients. I have discovered that Hsp90 and the …
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Analysis of axonal transport and molecular chaperones during neurodegeneration in drosophila
Neuronal dysfunction and cell death occurs during neurodegeneration. Animal models that express human disease genes and show neurodegenerative-like pathologies are widely used to study particular molecular systems in early neurodegenerative changes. Axonal transport (AT) is perturbed in several …
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Probing the role of Tat proofreading chaperones in the assembly of molybdoenzymes
… Tat proofreading, where the substrate specific chaperones, TorD and NapD, bind tightly to the signal peptides of these substrates, TorA and NapA, respectively, assisting in the assembly of the proteins.<br/>Work described in this thesis demonstrates that TorD simultaneously binds to two …
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Molecular chaperones and telomerase expression profiles and inhibition: Clinical implications for Glioma
Glioma, an infrequent form of cancer, continues to confer poor prognosis despite advances in current therapeutic techniques. This research identified the presence of hsp90a in glioma and investigated its potential as a diagnostic or therapeutic marker. l-Isp90ct is emerging as an encouraging target …
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Distant chaperones and N-glycan signals : new mechanisms of secretory pathway proteostasis
… of cells. At each step, proteins are helped by chaperones, which both shepherd proteins towards their native structures and serve as gatekeepers for export. Many proteins in the secretory pathway are also modified by installation of polysaccharides on specific asparagine residues. These …
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Biochemical Characterization of Binding Partners of Two Hsp70 Co-Chaperones In Saccharomyces Cerevisiae
… stress, cells deploy an array of molecular chaperones that assist in the repair or removal of misfolded proteins.</p> <p>Hsp70, an evolutionarily conserved molecular chaperone, promotes protein folding and helps maintain them in a functional state. Requisite co-chaperones, including …
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Characterisation of the (H3-H4)2-tetramer and its interaction with histone chaperones
… of H3 and H4 in complex with histone chaperones.Firstly, we determined the conformation of histones H3 and H4 when in complex with two histone chaperones from S. cerevisaie, Nap1 and Vps75. Within the nucleosome H3 and H4 form a heterotetrameric structure sustained by the interface …
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Regulatory network built by Cytochrome c with Histone Chaperones in response to DNA damage
… Protein Phosphatase 2A (PP2A). Moreover, histone chaperones assist the DNA repair mechanisms altering chromatin dynamics through their nucleosome assembly activity. Recent studies have reported that the mitochondrial respiratory protein cytochrome c is promptly translocated into the cell nucleus …
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Shield and Shuttle: Importins as Protective Chaperones and the Nuclear Transport Mechanism of H2A-H2B
… as 1) nuclear importers and 2) molecular chaperones. This thought stems back to characteristics of importins: they are negatively charged and shuttle positively charged DNA and RNA binding proteins prone to aggregation such as histones, ribosomal proteins, and transcription factors. …
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Regulating the stabilities of NOD1 and NOD2, two innate immune receptors, with sugars and chaperones
A healthy human body contains as many bacterial cells as it does human cells, and while some of these bacteria are known to cause diseases, many are beneficial and vital for our well-being, comprising the microbiome. Therefore, it is extremely important for us to distinguish the harmful, pathogenic …
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The role of the histone variant H3.3 and its chaperones in the response to DNA damage
… complexes: ATRX/DAXX and HIRA. H3.3 and its chaperones have been implicated in the response to and repair of various types of DNA damage. Furthermore, a supply of H3.3 has been shown to be required to maintain replication fork progression in the transformed avian cell line DT40, despite the …
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Pharmacological Chaperones of the Dopamine Transporter: A Strategy for Increasing Function of Wild Type and Mutant Transporter
… maturation of the transporter. Pharmacological chaperones have previously been used to rescue mutations in other membrane proteins, and we therefore examined the possibility of using pharmacological chaperones to rescue DTDS mutations. We developed a DAT surface expression assay in order to …
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