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Showing 1 to 1 of 1 for “"Chaperone inhibiton"”.
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Regulation of mammalian IRE1α: Co-chaperones and their importance
… to IRE1 to drive its oligomerisation. In the chaperone inhibition mechanism, unfolded proteins compete for the repressive BiP bound to IRE1 leaving IRE1 free to oligomerise. Currently, these two mechanisms respectively lack compelling in vivo and in vitro evidence required to assess their …