Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Channelopathy"”.
-
Regulation of signaling and function of the voltage-gated sodium channel complex by protein:protein interactions
… platform that can be adapted to search for any channelopathy-associated regulatory protein, these results lay the potential groundwork for a new class of drugs targeting Nav channels with a broad range of applicability for CNS disorders.
-
Genetic Mutations of K<sub>Ca</sub>2.3 and K<sub>Ca</sub>3.1 Channels Affect Ca2+ Sensitivity
… gating modulators as a novel target in these channelopathy-causing mutations. At the same time would guide us to design more potent and subtype-selective positive modulators targeting these channels.</p>
-
Genetic exploration of exercise associated sudden death in racehorses
… were not directly analogous to known human ion channelopathy genes, aquaporin 4 (AQP4) and potassium channel tetramerization domain containing 1 (KCTD1) on the region in chromosome 8, showed potential relevance to dysrhythmia development. Specific Aim 2: This study aimed to identify causative …
-
Computational studies of cerebellar cortical circuitry
… to characterize the effects of the P/Q-type Ca2+ channelopathy on the physiology of the cerebellar cortex in tottering mice and to explore the mechanisms that transform homeostatic deficits due to genetic mutations into transient phenotype such as episodic dystonia. Understanding the cerebellum …
-
Modelling Brugada Syndrome using induced pluripotent stem cells
… abnormal functional phenotype of an inherited channelopathy that is independent of structural abnormalities and that the relative immaturity of iPS cell-derived cardiomyocytes does not prevent their use as an accurate model system for channelopathies affecting the cardiac sodium channel Nav1.5. …
-
Structural and functional role of the extracellular loops and C-terminal domain of the voltage-gated sodium ion channel
Voltage-gated sodium ion channels (Nav) are central to action potential initiation through regulating the entry of sodium ions (Na+) into excitable cells including cardiomyocytes and neurones. The α-subunit of Nav consists of four homologous domains (DI-DIV), each consisting of six transmembrane …