Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Channelopathies"”.
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Zebrafish Models of KATP Channelopathies
… tissues, as well as the molecular basis of the channelopathies that result from loss-of-function or gain-of-function mutations in these channels. These studies have also highlighted that the available pharmacology to treat such diseases is limited. To overcome such limitations, a better …
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Modelling Brugada Syndrome using induced pluripotent stem cells
… a novel approach to studying inherited cardiac channelopathies with advantages over existing model systems. Whilst this technique has enormous potential to model inherited channelopathies, such as Brugada Syndrome, the derived cells have not been fully characterised and compared to foetal and …
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Synthesis Of Non-Natural Fmoc-Protected Amino Acids To Provide Novel Fluorescent Anion Probes And Their Incorporation Into Synthetic Peptides
… in grasping a better understanding of protein channelopathies such as cystic fibrosis. One day, the use of synthetic peptide ion channels will be an effective therapy to alleviate the many symptoms and even the causes of death that afflicts the many patients suffering from channelopathies today.
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Canais iônicos na epilepsia : aspectos fisiopatológicos e terapêuticos
… led some epileptic syndromes were considered channelopathies and therefore increased the understanding of convulsive disorders pathophysiology. The epileptic channelopathies are caused by mutations in genes encoding ion channels, either voltage-gated ion channels (Na+, K+, Ca2 + and Cl-) as …
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Genetic Mutations of K<sub>Ca</sub>2.3 and K<sub>Ca</sub>3.1 Channels Affect Ca2+ Sensitivity
… genes results in a broad spectrum of human channelopathies, including Zimmermann- Laband syndrome (ZLS), idiopathic non-cirrhotic portal hypertension (INCPH), and hereditary xerocytosis (HX). The impact of dysfunctional K<sub>Ca</sub>2.3/K<sub>Ca</sub>3.1 channels on human health has not …
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Mechanisms underlying polyene macrolide mediated rescue of growth in ion channel deficient yeast
… or dysfunctional protein ion channels, known as channelopathies, affect several organs and systems of the body including that of the heart, lungs, kidneys, and nervous system. Channelopathies can result in devastating and potentially life-threatening diseases. To date, more than 30 human …
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Genetic exploration of exercise associated sudden death in racehorses
… patients without a diagnosis at necropsy, ion channelopathies are found to be an important underlying cause. The genetics underlying EASD have been largely unexplored in horses.Hypothesis: Thoroughbred racehorses with variants in ion channels and other arrhythmogenic genes are predisposed to a …
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Augmentations vs. Restoration: A computational study of the effects of bacterial sodium channels on cardiac conduction.
… that could induce unidirectional block or channelopathies such as mutations leading to Brugada syndrome. BacNavs outperformed the endogenous channel in source-load mismatches due to increased action potential amplitude and slower inactivation kinetics. These conclusions were stable to …
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Defining a Novel Role for the E3 Ubiquitin Ligase Wwp1 in Cardiac Arrhythmogenesis
… coronary artery disease, cardiomyopatheis, or channelopathies), therapies that prevent SCD would have a major impact in medical practice as there are few options that currently exist. In the heart, gap junctions function as specialized channels that localize to the boundary between neighboring …
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Computational studies of cerebellar cortical circuitry
This thesis includes two directions of research regarding the function and physiology of the cerebellum. One direction was concentrated on the cerebellum involvement in motor control during a visually guided tracking task performed by non-human primates. The second effort aimed to characterize the …