Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Channel modulation"”.
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Ion channel modulation during Chlamydia trachomatis development
… recruits the host inwardly rectifying K+ channel Kir6 to the inclusion membrane from early in the infection cycle. Channel recruitment was most prevalent in stages of the C. trachomatis infection cycle when RB predominate, with Kir6 recruitment gradually diminishing in correspondence with …
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Sex Differences in Cardiac Electrophysiology
… communication rely on gap junctions, sodium channels and the perinexus. When conduction is disrupted it causes arrhythmias. When investigating these three critical determinants of cardiac conduction in guinea pig hearts, we determined that there are sex differences in two of three …
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The Effect of Noise Bandwidth and Modulation on Signal Detection for Single Neurons in the Frog Auditory Midbrain
… is challenging, and depends on the bandwidth and modulation depth of the background noise. A process that facilitates target detection in noisy environments is comodulation masking release (CMR), whereby the detectability improves when the noise is coherently modulated across a wide frequency …
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Exploring mechanisms of inhibition and inactivation in voltage-gated sodium channels using molecular simulations
Voltage-gated sodium (Nav) channels play a pivotal role in the conduction of electrical signals across the human body, with different subtypes expressed across excitable tissue in the brain, heart and muscle. Nav channels transiently form transmembrane pores by cycling through the closed, open and …
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Exploring mechanisms of inhibition and inactivation in voltage-gated sodium channels using molecular simulations
Voltage-gated sodium (Nav) channels play a pivotal role in the conduction of electrical signals across the human body, with different subtypes expressed across excitable tissue in the brain, heart and muscle. Nav channels transiently form transmembrane pores by cycling through the closed, open and …
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The Pharmacological Characterization of Hco-UNC-49, a GABA-gated Chloride Channel from the Parasitic Nematode Haemonchus contortus
… Hco-UNC-49 is a H. contortus GABA-gated chloride channel and is an orthologue to the UNC-49 channel from the free-living nematode Caenorhabditis elegans. Previous research by our group has shown that while the UNC-49 channels from the two nematodes share similar sequence homology they do not share …
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NOVEL THERAPEUTIC APPROACHES EMERGING FROM HCN CHANNELS STRUCTURAL AND FUNCTIONAL STUDIES
… cyclic-nucleotide gated 1 (HCN1) channels are the molecular determinants of the cationic Ih current that regulates spontaneous electrical activity and synaptic integration in neurons. Mutations in the HCN1 gene have been linked to Early Infantile Epileptic Encephalopathy (EIEE) and …
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Functional Studies of Novel Bioactives From Complex Host-Microbiomes as Drug Leads for Cancer, Infectious Disease, Depression and Pain
… approval of the "direct-from-the-sea" calcium channel blocker Prialt (ziconotide), marine natural products has been validated as a source for new medicines. However, the demand for natural products is extremely high due to the development of high-throughput assays and this bottleneck has …