Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Channel formation"”.
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Settling and sedimentation behavior of fine-grained materials
Channeling has already been an observed phenomenon that often occurs during settling and sedimentation processes of finer materials. However, it has been regarded as a minor factor affecting settling process, e.g. settling velocity or consolidation rate. In this study, settling behaviors of talcs, …
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Synthesis and function of the conserved motif of mycosamine-containing polyene macrolides
… to exert their biological activity through ion channel formation and thus represent small molecules with the capacity to perform a protein-like function. This function and the dose-limiting toxicity of AmB are thought to be dependent upon the presence of sterols in the cellular membrane, but the …
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Interaction of Colicin Ia With Escherichia Coli: I. Mechanisms of Colicin Insensitivity. Ii. Inhibition of Colicin Binding by Phenolic Uncouplers
… shows that the TonB function is not required for channel formation and maintenance within the cytoplasmic membrane, but, instead, is probably required for translocation of the colicin protein to the inner membrane.
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Elucidation of the mycosamine dependent sterol binding and antifungal activities of amphotericin B
… This natural product has been shown to form ion channels in model membrane systems and therefore represents a molecule with the capacity to perform protein-like function, i.e. the formation of a transmembrane ion channel. Efforts to improve the therapeutic index of AmB or harness its potential to …
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Less toxic yet still resistance evasive amphotericins and atomistic probing of the amphotericin B ion channel
… two major functions: antifungal activity and ion channel formation. For over 50 years AmB has remained the last line of defense against systemic fungal infections. Remarkably, AmB has evaded the development of drug resistance during this extensive clinical lifetime. Unfortunately, AmB’s utility is …
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Vasculogenic mimicry in bladder cancer and its association with cancer stem cells and human chorionic gonadotropin-beta
… metastasise. Vascular mimicry is the process of formation of tumour cell lined channels for nutrient transportation, independent of typical modes of angiogenesis. However, not much research has been done to investigate the occurrence of vascular mimicry (VM) in bladder cancer or to correlate the …
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Small molecules that imperfectly replicate protein function of missing proteins restore physiology in yeast and human epithelia
… robust protein networks comprised of pumps and channels drive targeted ions in targeted directions throughout the spectrum of living systems. We hypothesized that relatively unselective and unregulated small molecule mimics of missing protein transporters might be capable of collaborating with …
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Morphodynamics of large anabranching rivers : the case of the Madeira River, Brazil
Anabranching channels are the dominant channel pattern of large rivers worldwide. The top nine largest rivers of the world by water discharge, in particular, all develop anabranching channels. Given the limited understanding on large river morphodynamics and the mechanisms of formation and process …
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Hydrodynamic and sediment transport modeling of deltaic sediment processes
… the early phases of deltaic bar and distributary channel formation and sediment transport on an adverse slope could be simulated with a 2D finite element sediment transport model. The models used were RMA2 and SED2D modules of the TABS-MD model suite. A finite element mesh of the lower Atchafalaya …
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Slow-release cross-coupling and an advanced method for β-glycosylation: methods stimulated by amphotericin B
… that additionally has the ability to form ion channels in biological membranes, a capacity normally associated with proteins. Better understanding the dynamics of channel formation and how it relates to AmB’s antifungal activity would stand to enable both the rational development of derivatives …
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Sedimentology of the Bullion Creek and Sentinel Butte formations (Paleocene) in a part of southern McKenzie County, North Dakota
… of the Bullion Creek and Sentinel Butte Formations (Paleocene) in western North Dakota has been variously ascribed to lacustrine, meandering fluvial, and deltaic settings. The purpose of this study was to interpret the depositional environments, depositional history, and provenance of the …
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Multigate MOSFETs for digital performance and high linearity, and their fabrication techniques
… facing great challenges to overcome severe short-channel effects. Multigate MOSFETs are one of the most promising candidates for scaling beyond Si CMOS, due to better electrostatic control as compared to conventional planar MOSFETs. Conventional dry etching-induced surface damage is one of the …
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Electronic tuning of site selectivity and semisynthesis of C2'-deoxyamphotericin B
… AmB is known to self-assemble into ion channels in phospholipid membranes containing sterol. The resulting membrane permeabilization has long been the leading hypothesis for the primary mechanism of antifungal activity. Three possible interactions involving the carboxylic acid and …
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Exploring equifinality in a landscape evolution model
… selected for variation, covering mass movement, channel formation, fluvial erosion and weathering processes, and value ranges appropriate for the catchment are established from published data and calibration. Parameter space sampling is then carried out using a response surface methodology …
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Analysis and Modeling of Landscape Topography: Statistical Description and Evolution Under Natural and Disturbed Conditions
… and non-regular points of the watershed, and the formation of spatially organized ridge and valley patterns.</p><p>We start from the analysis of topographic slopes under natural and accelerated soil erosion. Using large topographic datasets from mountain ranges worldwide, we show that the …
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Structural studies of membrane-associated complexes by solid-state NMR
… plasma concentrations of calcium results in the formation of PS-rich nanodomains on the membrane surface, which are proposed as high affinity binding sites for coagulation factors. Phosphatidylethanolamine (PE) has been shown to enhance the pro-coagulation activity of PS membranes, and is …
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Bio-physical controls on tidal network geomorphology
… order and the median depth of the network main channel have the highest discriminating weight on the patterns investigated. High correlation between the latter variable and network main channel width has revealed that linear, linear-dendritic and dendritic networks followed a transitional …
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Mesoscale Forces and Grain Motion in Granular Media Exhibiting Stick-Slip Dynamics: Effects of Friction and Grain Shape
… which the intruder carves out a completely open channel in the granular material. With a geometrical model, we relate the packing fraction of open channel formation to a characteristic packing fraction of the material and the ratio of the intruder's diameter and the width of the annular cell, and …
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The evolution of tidal coastal landscapes and the controls on pathways to equilibrium
… However, residence time, development of channels and energy dissipation were observed to be different. In the case of available incoming mud from open boundaries, equilibrium bathymetry was dominated by the mud supply and sediments accreted all over the domain, forming a mudflat and a …
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Mechanisms underlying polyene macrolide mediated rescue of growth in ion channel deficient yeast
… caused by missing or dysfunctional protein ion channels, known as channelopathies, affect several organs and systems of the body including that of the heart, lungs, kidneys, and nervous system. Channelopathies can result in devastating and potentially life-threatening diseases. To date, more …