Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Changeover time"”.
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Investigation of a process analytical technology (PAT) for rapid cleaning verification in the pharmaceutical industry to reduce product changeover time
… complete the verification study, and during this time, the manufacturing equipment is not in use. In addition to this downtime, another major drawback of the current method is the poor swab recovery which may lead to an ambiguous result. Therefore, the pharma regulators are encouraging to develop …
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Enhancing machine availability in plastic SMEs through lean and TPM: evidence from a peruvian case study
… significant challenges related to machine downtime and prolonged set-up times, which limit productivity and increase operational costs. Previous studies have highlighted the benefits of Lean Manufacturing and Total Productive Maintenance (TPM) for improving equipment efficiency, yet the …
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Optimal handling of Highly Active Pharmaceutical Ingredients during milling and blending operations
… Automated WIP and CIP systems decrease changeover time and allow for higher equipment availability. Additionally, the results of the analyses suggest that manufacturers consider standardizing transportation containers with the upstream vendors and downstream consumers. Lastly, from an …
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Cost modeling for monoclonal antibody manufacturing
… However, when using standard costs it can be time-consuming to extrapolate and predict costs when inputs and assumptions (such as product mix or process parameters) are changed. This project describes development of a model that allows the factory to quickly and easily simulate new product …
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Estimating and Optimizing Throughput in an Aluminum Rolling Mill Using Capacity Modeling and Optimization Techniques
… mix to reduce production hours lost to product changeover time. The scheduling of a CCL is considered a single machine scheduling problem (SMSP), and the introduction of transition coils is considered a sequence-dependent setup times (SDSTs) problem. This last portion of the paper will focus on …
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Prioritization and integration of lean initiatives with theory of constraints
… operation and the high leverage of machine changeover time in productivity improvement. We conclude that the Theory of Constraints can provide an effective focusing tool for the lean enterprise.
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Econometric modelling in a changing, globalised world
… transmission channels selected for inclusion to changeover time. Using our approach, we analyse crisis episodes in Latin America. We only detect abrupt contagion during the global financial crisis from the US to Argentina and Brazil. During crises, results also show that macroeconomic and …
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Early Stages of the Aluminothermic Process: Insights into Separation and Mould Filling
… and computational methods to predict the time duration of a complete separation and to obtain a better understanding of the internal multiphase flow within the crucible and mould. The decomposition of AT reaction products after the combustion and the subsequent mould filling by thermite …
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A method for setup time reduction in high precision machine cells
… on an important aspect of production, machine changeover, or setup time. Setup time is defined as the elapsed time between producing the last part from the most recent lot to the first part of an incoming lot. The research had four objectives. First, an existing method to reduce machine …
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The Benefit of Using Simulation to Improve The Implementation of Lean Manufacturing Case Study: Quick Changeovers to Allow Level Loading of The Assembly Line
… of the operations was improved to allow quick changeovers. The changeover time was reduced by 60% and with a few additional changes changeovers could be completely external. In order to be able to conduct simulation experiments to find the optimum production schedule, cycle times were gathered …