Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Chan-Lam"”.
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Expansion of the iterative cross-coupling synthesis strategy through Csp3 halide cross-coupling, Mida boronate synthesis, and chan-lam couplings
… entire iterative cross coupling platform to the Chan-Lam coupling to form carbon-heteroatom bonds.
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High-Throughput Methods For Reaction Development Using The Mosquito® Liquid Handling Robot
… for quantitative data generation. The Chan-Lam reaction of an amine and aryl boronates was used as an initial proof-of-concept reaction to standardise the high-throughput protocol. All parts of the protocol were optimised including the creation of an Excel spreadsheet and Mosquito® …
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Synthesis, Vinylation and Rearrangement of NH-Isoxazolines and Copper Catalyzed 6 Pi Electrocyclization
… the gem-dione under basic conditions and the mechanism of the corresponding products was further investigated. Chapter 2 discusses a ring expansion reaction of azetidine–N–oxides to form highly functionalized isoxazolidine products with up to 3 contiguous stereocenters in excellent …
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ARYL-HETEROATOM CROSS-COUPLING WITH DUAL NICKEL/PHOTOCATALYST PROTOCOLS : THEORY, APPLICATIONS AND RECENT DEVELOPMENTS
… protocols (Buchwald-Hartwig-, Ullmann- and Chan-Lam couplings) illustrating the general advantages and disadvantages of each cross-coupling method. The scope of different dual nickel/photocatalyst protocols are then explored, concentrating on cross-coupling of amines, alcohols/thiols and …
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Synthesis of phosphorus/sulfur-based antivirals
… and phosphonic acids via copper-catalysed Chan-Lam coupling of adenine-derived nucleobases with boronic acids and esters. Ten novel aryl-linked phosphonates/phosphonic acids were successfully synthesised and have been evaluated for activity against HIV and hepatitis B. The application of …
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Synthesis of Novel Amino Acids and Peptidomimetics as Tools for Drug Discovery
… block the invasion of leukocytes into inflamed tissues in the brain and in the gut, biotin-R8ERY represents a potential cure for multiple sclerosis and Crohn’s disease. In this work, a structure-activity relationship study with biotin-R8ERY-containing side-chain modified tyrosine building …