Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Chalcones"”.
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Chalcones derived from m-nitroacetophenone
… to prepare substituted derivatives of various chalcones having the nitro group substituted in the 3<sup>1</sup>-position, the idea being to help complete the series of chalcones having the nitro group in that position. This was to be done by condensing various substituted benzaldehydes with …
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Assessment of synthetic chalcones as cancer chemopreventive agents
… In the current research a library of synthetic chalcones were investigated, which were synthesised and kindly gifted by Prof Arroo from De Montfort University (DMU). These chalcones are categorised based on their chemical structures such as alkoxyl group (17 chalcones), methylene-dioxy group (13 …
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Characterisation and investigation of structual relationships of 4,4'-disubstituted chalcones
… fifty crystal structures of 4,4’-disubstitituted chalcones, X-C6H5-CO-C2H2-C6H5-Y, where X = CF3, Br, Cl, F, H, Me, Et, OMe and Y = Br, Cl, F, H, Me, Et, OMe are investigated by comparative study of the molecular packing in each of the structures. The members of this family contain no strong …
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Chalcone derivatives from pyrrole-2-aldehyde
… recent years extensive preparation and study of chalcones has been carried out utilizing chalcones for their biological effects in medical and pharmaceutical fields. It has been shown that certain highly substituted compounds present in the flower pigments as additives to adhesive absorb …
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Organomanganese compounds in organic synthesis
… and reactions of some cyclomanganated chalcones, dienones and aryl ketones. Investigation has previously been undertaken into the reaction of cyclomanganated chalcones and dienones with alkynes to give both pyranyl and cycloheptadienyl Mn(CO)₃ complexes. In the current study, the …
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Expression and purification of HGXPRT from Plasmodium falciparum and characterisation of its interaction with an effector chalcone
… characterising the interaction of the effector chalcones with the protein.
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Novel Antimalarial and Antitubercular Agents Based on Natural Products
… dihydroartemisinin-isatin, dihydroartemisinin-chalcones and other miscellaneous hybrids. These were evaluated for antiplasmodial activity against the chloroquine resistant (W2) and chloroquine sensitive (D10) strains of Plasmodium falciparum as well as for inhibitory activity against cysteine …
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Synthesis and kinetics of isomerisation of 2',6'-dihydroxychalcones
… KC1) at 30°C for the following 2' ,6'-dihydroxychalcones: 2' ,6'-dihydroxychalcone (34); 2' ,6'-dihydroxy-4-methoxychalcone (38); 2' ,6'-dihydroxy-3,4-dimethoxychalcone (40); 2' ,6'-dihydroxy-3,4,5-trimethoxychalcone (42); 2' ,6'-dihydroxy-2,4,6-trimethoxychalcone (44); 4-chloro-2' …
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The Stetter reaction : synthesis of complex spiro Bis-indanes and studies on quaternary centre formation
… the Stetter-aldol-aldol reactions of o-formyl chalcones 36 with phthalaldehyde derivatives 27. The scope, limitations, and potential applications of these remarkable complexity-generating domino reactions are discussed. Preliminary results in the formation of quaternary centers via the …
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Synthesis and reactivity of alpha-thio-beta-chloroacrylamides and alpha-thio-beta-chloroenones
… of these compounds. The biological activity of chalcones is also summarised in this chapter. The second chapter delineates the stereoselective synthesis of the novel α-thio-β-chloroenones from the corresponding α-thioketones in a multistep reaction cascade initiated by a NCS-mediated …
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A study of methods of preparation of phthalaldehyde
… years on the general field centering around the chalcones, flavones, and anthocyanidins. Members of the three classes of compounds exist as natural products and occur widely as coloring matter in flowers and plant saps.</p><p>An attempt has been made to work out a new method for the preparation …
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Structural studies of organic crystals of pharmaceutical relevance. Correlation of crystal structure analysis with recognised non-bonded structural motifs in the organic solid state
… range of pharma-relevant materials including chalcones, cryptolepines, biguanides and xanthines. These selected systems were validated using functional group and molecular analysis and correlating them to the Cambridge Structural Database. Crystallization studies are done on these selected …
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Concentration dependency, mode of action and characterization of compounds involved in alfalfa autotoxicity
… present in the sample had characteristics of chalcones and flavones. Medicarpin was not found in the extract.
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Reactions of cyclomanganated compounds
… were derived from aryl and heteroaryl ketones, chalcones, dienones and azabutadienes. A preliminary investigation has previously been undertaken into the reaction of carbon disulfide with some orthomanganated aryl ketones. In the present study these reactions were further investigated, with the …
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Synthesis of Novel CYP1 Activated Heterocyclic Anticancer Prodrugs
… CYP1 enzymes over-expressed at tumour sites. The chalcones have been shown to exhibit effective anti-cancer prodrug activity, but are labile to photoisomerisation reactions converting the potent trans isomer to the less toxic cis isomer. Several heterocyclic ring systems were incorporated across …
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Advancements in green chemistry approaches to chemical synthesis
… such as the hydrogenation of quinolines, chalcones, and substituted 1,10-phenanthroline. The catalytic process is safe and sustainable as we have mitigated its flammability hazard, making it more suitable for potential large-scale industrial applications. The second advancement was …
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Novel Photochemical Methodologies for Diversity Oriented Synthesis and Screening of Combinatorial Libraries
… <em>Diels-Alder</em> addition of heterocyclic chalcones and other benzoyl ethylenes to a variety of dienes, followed by the <em>Paternò-Büchi</em> reaction, was described as an alkene-carbonyl oxametathesis. This methodology offers a rapid increase in molecular complexity and diversity of the …
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Design, synthesis, and biological evaluation of dihydronaphthalene and chalcone-based anticancer agents inspired by the natural product combretastatin A-4.
… focused library of α-conformationally restricted chalcones and related analogues, which were evaluated (in collaborative studies) for inhibition tubulin polymerization, and cytotoxicity against human cancer cell lines (NCI-H460, SK-OV-3, and DU-145). Another targeting strategy relies on regions of …
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In search of human cytochrome P450 1A1 enzyme inhibitor
… to cancer. Natural products such as flavonoids, chalcones and stilbenes have attracted a great deal of attention since these compounds have an ability to modulate the activity of CYPs by inhibiting CYP-specific enzymatic activity. Several compounds have been found which potently inhibit CYP1 …
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The powerful combination of novel organosulfur methodology and continuous flow technology
… this provided access to the Z-sulfoxide chalcones for the first time. Chapter 3 details the successful extension of the NCS-mediated chlorination reaction to include lactam derivatives, synthesising a number of novel α-sulfenyl-β-chloro-enelactams. Once again, the mechanistic route to …
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