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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"Chalcone."”.
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Chalcone derivatives from pyrrole-2-aldehyde
<p>Claisen first synthesized Chalcone in 1881 by condensing acetophenone with benzaldehyde using sodium methoxide as a condensing agent. Chalcone and its derivatives have been prepared primarily as intermediates for the synthesis of anthocyanins and other related pigments.</p><p>In recent years …
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Characterization of chalcone synthase genes in red raspberry cultivar (rubus idaeus)
… involves type III polyketide synthases (PKSs): chalcone synthase (CHS), which is the first enzyme of the flavonoid synthetic pathways leading to synthesis of various anthocyanins. The European red raspberries are a commercially important fruit that needed both for fresh fruit consuming and food …
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Novel synthetic methodology employing organosulfur chemistry in the synthesis of chalcone derivatives
… this work is the synthesis of a series of novel chalcone derivatives which were prepared using Stille coupling. Six a-thiochalcones and five a-sulfinylchalcones synthesised in this work were accepted by the National Cancer Institute (NCI) for testing and were found to be extremely potent growth …
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Endogenous short interfering RNAs that silence chalcone synthase result in pigment pattern formation on soybean seed coats
… dominant alleles correspond to duplications of chalcone synthase (CHS) genes leading to production of CHS siRNAs which in turn degrade CHS mRNAs resulting in yellow seed coats (Tuteja et al., 2009 and Vodkin et al., 2012). However, it was not known if the same phenomenon applied to the yellow …
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Expression and purification of HGXPRT from Plasmodium falciparum and characterisation of its interaction with an effector chalcone
… characterising the interaction of the effector chalcones with the protein.
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Examination of the antibacterial activities of some semi-synthetic chalcone-derivatives alone and in combination with polymyxin B.
… of action. This study demonstrated that two chalcone derivatives - F1 and F23 - had MICs from 16 mg/ml to over 512 mg/ml, when used against two plant pathogens (P. caratovoram and C. michiganensis, subsp. michiganensis) and other important clinical bateria. Both compounds also demonstrated an …
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Design, synthesis, and biological evaluation of dihydronaphthalene and chalcone-based anticancer agents inspired by the natural product combretastatin A-4.
… focused library of α-conformationally restricted chalcones and related analogues, which were evaluated (in collaborative studies) for inhibition tubulin polymerization, and cytotoxicity against human cancer cell lines (NCI-H460, SK-OV-3, and DU-145). Another targeting strategy relies on regions of …
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Studies on the mechanism of action of the bioflavonoid Hesperidin methyl chalcone in causing vascular and intestinal smooth muscle to relax
… of action of the bioflavonoid, hesperidin methyl chalcone (HMC), in causing smooth muscle to relax. The term bioflavonoid refers to several compounds that can be extracted from the mesocarp of citrus fruits. They have been the subject of investigation and controversy since 1936. Much of this is …
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Anti-cancer and anti-malarial 4-aminoquinoline derivatives : synthesis and solid-state investigations
… employed for this project was to hybridize chalcone moieties and their Mannich base derivatives with the 4-aminoquinoline moiety. This dual drug concept uses the basic structure of the chalcone scaffold, which has a wide range of known antimalarial and anticancer activities, and is …
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Novel Antimalarial and Antitubercular Agents Based on Natural Products
… the non-peptidic natural product isatin and the chalcone scaffold. In this way a series of hybrids were constructed which can be subdivided into three main groups: (i) thiolactone-isatin hybrids, (ii) -amino alcohol thiolactone-chalcone and isatin-chalcone hybrids, and (iii) …
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Exploring protein interactions and intracellular localization in regulating flavonoid metabolism
… to probe the role of subcellular localization of chalcone synthase, the first committed flavonoid biosynthetic enzyme, on metabolic flux, and to characterize a novel chalcone synthase-interacting protein. The over-expression of this interacting protein induces novel phenotypes that are likely …
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Dual-omics approach for 3,4-dihydroisocoumarin characterisation from Hydrangea serrata and isolation of polyketide synthases for heterologous expression in Pseudomonas putida KT2440
… biocatalysis mechanism is well known from the chalcone synthase superfamily, a group of plant specific Type III polyketide synthases. Chalcone synthases and their homologues, the stilbene synthases produce a huge amount of specialised plant metabolites including phenylpropanoids. The …
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Development of antibodies for characterizing the Arabidopsis flavonoid biosynthetic pathway
… cDNAs from Arabidopsis coding regions of chalcone synthase (CHS) and chalcone isomerase (CHI) were sub-cloned in frame into a bacterial expression vector as fusions with glutathione Stransferase (GST) using standard directional cloning techniques. Analysis of crude extracts of Escherichia …
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Investigating Extreme Lifestyles Through Mangrove Transcriptomics
… characterized phenylalanine ammonia-lyase (PAL), chalcone synthase (CHS), and dihydroflavonol reductase (DFR) gene families in R. mangle , which are at major regulatpry points in the phenylpropanoid pathway. I have identified one DFR, two CHS, and ten PAL genes in R. mangle . Differential …
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Synthesis and kinetics of isomerisation of 2',6'-dihydroxychalcones
The first-order rate constant, kₒbₛ, for the chalcone - flavanone isomerisation has been determined over the pH range 0-14 in water (μ = 1.0 mol 1⁻¹ with KC1) at 30°C for the following 2' ,6'-dihydroxychalcones: 2' ,6'-dihydroxychalcone (34); 2' ,6'-dihydroxy-4-methoxychalcone (38); 2' …
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Ecological and Genetic Status of the Purple Pitcher Plant, <i>Sarracenia purpurea</i> L., in Maryland and Virginia
… restriction fragments from the intron of the chalcone synthase gene to compare <em>S. purpurea</em> populations and determine whether the subspecies concept was supported. I performed a census of existing populations, compiled all known historical data on the species, and investigated the …
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Structural Characterization of the Flavonoid Enzyme Complex
… characterize a series of loss-of-function chalcone synthase (CHS) alleles and to define the molecular basis of the interaction between CHS and the second enzyme of flavonoid biosynthesis, chalcone isomerase (CHI). CHS proteins encoded by five previously characterized alleles were …
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In search of human cytochrome P450 1A1 enzyme inhibitor
… to cancer. Natural products such as flavonoids, chalcones and stilbenes have attracted a great deal of attention since these compounds have an ability to modulate the activity of CYPs by inhibiting CYP-specific enzymatic activity. Several compounds have been found which potently inhibit CYP1 …
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Synthesis and Computational Studies on Hiv-1 Integrase Inhibitors
… biological evaluation of 3-keto salicylic acid chalcones as novel HIV-1 IN inhibitors. In the chalcone series, the most active compound, 5-bromo-2-hydroxy-3-[3-(2,3,6-trichloro-phenyl)- acryloyl]-2-hydroxybenzoic acid (96) was selectively active against IN strand transfer (ST) with IC50 of 3.7 …
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Immunomodulation of Flavonoid Biosynthesis in Transgenic Arabidopsis thaliana
… from a phage display library using Arabidopsis chalcone isomerase (CHI) of the flavonoid biosynthetic pathway as the antigen. Each of the genes encoding the scFv's was cloned into a plant transformation vector, which was subsequently used to generate transgenic plants. One transgenic line with …
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