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Showing 1 to 1 of 1 for “"Chagas disease, inflammation, oxidative stress, SIRT1, macrophages"”.
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SIRT1 ACTIVATION IMPROVES HEART FUNCTION THROUGH INHIBITION OF INFLAMMATION IN CHAGAS DISEASE
Chronic chagasic cardiomyopathy (CCM) is presented by increased oxidative/inflammatory stress and decreased mitochondrial bioenergetics. SIRT1 senses the redox changes and integrates mitochondrial metabolism and inflammation; and SIRT1 deficiency may be a major determinant in CCM. To test this, …