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Showing 1 to 20 of 45 for “"Chagas disease"”.
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Factors Affecting the Epidemiology of Chagas' Disease
Made available in DSpace on 2014-12-09T22:30:06Z (GMT). No. of bitstreams: 1 6507151.pdf: 7185978 bytes, checksum: ce02f0aad3fbd6401e2d135e8b1affcf (MD5) Previous issue date: 1965
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Efficacy and Safety of Pharmacological Treatments of Chagas Disease
Background: Chagas disease is a neglected tropical disease that causes a high burden of disease in the Americas. Current trypanocidal treatments vary drastically in efficacy, depending on the stage of disease and the drugs administered. Conventional trypanocidals present a significant risk of …
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The eco-epidemiology of Chagas disease risk in Panama
Chagas disease is a vector-borne disease affecting between 5 to10 million people world-wide. It is spread by dozens of species of blood-feeding triatomines (Hemiptera: Reduviidae). Trypanosoma cruzi, a kinetoplastid protozoan parasite and causative agent of Chagas disease, is shed in the feces of …
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The Beneficial Effect of Vitamin E and Selenium During Experimental Chagas' Disease
… positive synergistic effect during experimental Chagas' disease. In the first phase of the study, 25 female C3HeB/FeJ mice were infected with a Brazil strain of Trypanosoma cruzi while receiving vitamin E supplementation of 0 IU/kg, 200 IU/kg, 400 IU/kg, 600 IU/kg, 800 IU/kg in their diets. In …
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SIRT1 ACTIVATION IMPROVES HEART FUNCTION THROUGH INHIBITION OF INFLAMMATION IN CHAGAS DISEASE
Chronic chagasic cardiomyopathy (CCM) is presented by increased oxidative/inflammatory stress and decreased mitochondrial bioenergetics. SIRT1 senses the redox changes and integrates mitochondrial metabolism and inflammation; and SIRT1 deficiency may be a major determinant in CCM. To test this, …
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The Effect of Dietary Supplemented Vitamin E and Selenium on Experimental Chagas' Disease
… of Trypanosoma cruzi, the causative agent of Chagas' disease. To study the role of diet on the course of experimental Chagas' disease, C3HeB/FeJ mice were fed pelleted, synthetic food containing no vitamin E and selenium, 800 IU/kg vitamin E, 2 ppm selenium, or food containing 800 IU/kg …
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Chagas disease, need and progress made in implementing donor blood screening in the United States.
Background: Chagas disease is a parasitic infection caused by Trypanosoma cruzi affecting 11 million people worldwide. The condition can be acquired via exposure of a wound or mucosa to infected feces from a reduviid bug, blood transfusion or congenitally. It is estimated that there are between …
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Chagas Disease in the United States: the Emerging Threat and the Role Climate and Awareness Play in Its Spread
… the roles of temperature variability and disease awareness in the emergence of Chagas disease (American trypanosomiasis). Chagas disease is endemic in Latin America and primarily spreads to humans directly via the triatomine vector. Hosts for most triatomine species are mainly rodents and …
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Crescimento da literatura brasileira de doença de Chagas: análise bibliométrica
Historical outline of Chagas' disease, since its discovery by Carlos Chagas up to currently research areas, in Brazil. Goffman's theory on the works on Chagas' disease and the use of the deterministic model, verifying a growth of the literature after 1933.
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Avaliação soroepidemiológica da Doença de Chagas no município de Santo André-PB
Chagas disease (CD) is an infectious disease caused by Trypanosoma cruzi parasite and is a serious public health problem. It is a neglected disease may be asymptomatic or have cardiac and / or digestive complications. Therefore this study aims to carry out a seroepidemiological assessment of Chagas …
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High Diversity of Trypanosoma Cruzi Discrete Typing Units Circulating in Triatoma in Western Mexico
Chagas disease is caused by the protozoan parasite <em>Trypanosoma cruzi</em>, which is transmitted to domestic and sylvatic mammals via the feces of hematophagous hemiptera of the subfamily Triatominae (Reduviidae). <em>Trypanosoma cruzi</em> is found only in the Americas and displays remarkable …
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Small molecule inhibitors of parasitic enzymes
… agents of Malaria, African sleeping sickness and Chagas disease, (ii) development of potential new and novel anti-trypanosomal inhibitors of trypanosome alternative oxidase, and (ii) synthetic and methodological studies.
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Mapping and modeling of neglected tropical diseases in Brazil and Bolivia
Accurately defining disease distributions and calculating disease risk is an important step in the control and prevention of diseases. This study used geographical information systems and remote sensing technologies within the MaxEnt ecological niche modeling program to create predictive risk maps …
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Understanding and modulating macrophage metabolism for improving inflammatory functions against Trypanosoma cruzi infection
… infection. T. cruzi is the etiologic agent of Chagas disease, which affects over 8 million people and current therapy has limited efficacy. Macrophages are one of the first sentinels to T. cruzi infection yet are susceptible to infection. Prior research indicated that glycolysis and broken …
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Small molecules with anti-trypanosomal and anti-leishmanial activity
Parasitic diseases such as Human African Trypanosomiasis (HAT), Chagas disease and Leishmaniasis cause thousands of fatalities each year. Current chemotherapy is based on drugs discovered over 60 years ago that are expensive and difficult to administer. The drug-pipeline is virtually dry and the …
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Perfil epidemiológico da infecção por Trypanosoma cruzi em regiões de vulnerabilidade do Brasil
… profile of individuals with suspected acute Chagas disease in Northern Brazil and to evaluate the entomological control of T. cruzi vectors in an endemic area of the Rio Grande do Norte state. Methods: The epidemiological profile of individuals with suspected acute Chagas disease was …
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Effects of Antioxidant Supplementation with Vitamin E and Selenium on Cytokine Production in Mice Infected with Trypanosoma Cruzi
… parasite Trypanosoma cruzi during experimental Chagas' disease. Supplementation of mice with vitamin E and selenium at levels well above the recommended daily allowance for these two substances results in significantly decreased parasitemia levels and increased longevity. However, the …
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Inhibitors of human cathepsin L and cruzain as therapeutic agents.
… target for the development of new chemotherapy. Chagas disease, a result of Trypanosoma cruzi infection, is the third largest parasitic disease challenge worldwide after malaria and leishmania and there is an urgent need for development of new therapeutic agents against Chagas disease. From the …
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New Chemotherapeutic Approaches for the Treatment of Parasitic Protozoan Diseases
… for the treatment of parasitic protozoan diseases. The work presented in this thesis focuses on the design, synthesis, and screening (in vitro and in vivo) of bisphosphonates as a novel class of anti-parasitic agents. The infectious agents targeted in this study are Trypanosoma brucei, …
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The Effects of Lead Acetate on Host Susceptibility to Trypanosoma Cruzi
… parasite, causes American trypanosomiasis or Chagas' disease. The infective stage of this parasite resides in the hindgut of the reduviid bug (family Reduviidae), which is both host and vector, and is transmitted to the mammalian host through fecal material released during a blood meal. …
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