Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"ChREBP"”.
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Regulation of Energy Metabolism by Fructose in the Liver
… glycogen and triglycerides in liver. SREBP-1 and ChREBP, and possibly FoxO1, likely mediate gene induction by dietary fructose. The study also suggests that further ChREBP activation occurs in the nucleus after nuclear translocation of ChREBP in F-fed rat.
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Microarray-basierte Expressionsanalysen des weißen Fettgewebes der NZO-Maus sowie der Langerhansschen Inseln der NZL-Maus : zwei Modelle für das metabolische Syndrom
… hin. Der Transkriptionsfaktor Mlxipl (ChREBP; 3,8-fach erniedrigt durch die HF) stellt in Langerhansschen Inseln eines der am stärksten herunter regulierten Gene dar. Ferner wurde ChREBP, dessen Funktion als glucoseregulierter Transkriptionsfaktor für lipogene Enzyme bislang in der …
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Rgs16 is a Pancreatic Reporter of Chronic Hyperglycemia in Diabetes
… Carbohydrate Response Element Binding Protein (ChREBP), as pancreatic Rgs16::GFP was absent in STZ-treated ChREBP KO mice. We found that Rgs16::GFP is also expressed in Pancreatic Ductal Adenocarcinoma (PDAC) tumors and primary tissue culture cells. RNA-Seq analysis revealed that cultured PDAC …
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The impact of glucotoxicity on pancreatic β-cell function
… islets also displayed increased expression of ChREBP and TXNIP. Down-regulation of ChREBP and TXNIP in INS-1 832/13 cells cultured at high glucose suppressed high glucose-induced increase in VDAC1 expression. The cultured INS-1 832/13 cells also exhibited a reduced expression of VADC1 when …
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A study of the protective effects of an aspalathin enriched green rooibos extract on experimentally induced hepatic steatosis
… (TNF-α) and glucose metabolism (GCK and ChREBP) were assessed. Further investigation was done using leptin-receptor deficient C57BL6/J db/db mice (n=8/group) and their lean littermates (db/+) (n=8/group). The mice received standard ii rodent chow ad libitum. Treatments were given daily …
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Regulation of milk fat synthesis by dietary fatty acids
… factor (TF) SREBP-1C. Potential roles of the TF ChREBP, PPARG, and INSIG1 were also established. A subsequent study aimed to establish whether these mechanisms operated in lactating dairy cows. Compared with un-infused controls and a t10c12 CLA negative control, post-ruminal infusion of butterfat …
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Development of a Pediatric Model of Nafld in Neonatal Iberian Pigs
… and PPARγ (<em>P ≤ 0.001</em>), and decreased ChREBP (<em>P ≤ 0.001</em>). A probiotic affect was seen as pigs fed CON-P and HFF2-P had higher insulin and HOMA values were increased (<em>P ≤ 0.05</em>). Western blot analysis showed dysregulation of autophagy in liver of pigs fed CON-P and …