Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Cervical tissue"”.
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Mechanical and biochemical properties of human cervical tissue
The mechanical integrity of cervical tissue is crucial for maintaining a healthy gestation. Altered tissue biochemistry can cause drastic changes in the mechanical properties of the cervix and contribute to premature cervical dilation and delivery. This work presents an investigation of the …
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Property determination of biomedical polymer scaffolds for cervical tissue repair
Cervical cancer is the second most common cancer disease among women and around 1/2 million women are diagnosed each year. Treatment options include surgery, such as hysterectomy, or radiotherapy. Both treatments make childbearing impossible. Other well-known medical issues related to the uterine …
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An investigation of the structure-function relationship in human cervical tissue
… biochemical and mechanical properties of the cervical tissue are suspected to play an important role in spontaneous pre term birth. Slight changes in the biochemical properties are known to cause softening of the cervical tissue thus weakening the structure. Premature softening of the cervical …
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A three-dimensional constitutive model for the mechanical behavior of cervical tissue
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2003.
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Examining viscoelastic response of pregnant rat cervical tissue using 3, 4, and 5 element spring and dashpot models
… of death and abnormality among newborn infants. Cervical insufficiency is one of the major causes of preterm birth. Unfortunately, this asymptomatic condition remains hidden to many patients until preterm birth occurs. Accurate characterization of the mechanical behavior of cervical tissue can …
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Differential effects of progestogens on HIV-1 replication and host gene expression in primary PBMCs and cervical tissue explants
… regulation of selected genes was investigated in cervical tissue explants from premenopausal, HIV-1negative, and contraception negative women and peripheral blood mononuclear cells (PBMCs) from women, by real time quantitative PCR, western blotting and Luminex assays, in response to …
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Real time PCR and fluorescent in situ hybridization in the detection of the physical tsate of human papillomavirus 16 and 18 in paraffin embedded cervical tissue
… (HPV) are the etiologic agents of most cervical dysplasia and all cervical carcinoma. Integration of high risk HPV into the human genome is thought to be a critical event in the progression from cervical dysplasia to invasive cervical carcinoma. The ability to use molecular assays in the …
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Deep learning and localized features fusion for medical image classification
… of handcrafted features is developed to classify cervical tissue histology images into different cervical intra-epithelial neoplasia classes. Using deep learning combined with handcrafted features improved the accuracy by 8.4% achieving 80.72% exact class classification accuracy compared to 72.29% …
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Quantitative spectroscopy for detection of cervical dysplasia
The current clinical standard for cervical cancer diagnosis is colposcopy, a procedure that involves visual inspection and biopsy of at-risk tissue, followed by histopathology. The major objective of colposcopy is detection of high-grade squamous intraepithelial lesions (HSIL), which are …
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Biomechanical properties of engineered collagen scaffolds
… to enter the extracellular matrix and weaken the tissue. By performing tension tests on cervix tissue in vivo, one can produce a theoretical fit to predict relevant collagen network parameters, which can be compared with those of non-pregnant cervical tissue to indicate the early onset of cervical …
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Clinical, biochemical and morphological aspects of cervical ripening in the first trimester
… of the foetus at parturition. This process, cervical ripening, has been described similar to an inflammatory reaction of the extracellular matrix involving activation of inflammatory cytokines, matrix metalloproteinases and breakdown of the collagen framework. Cervical ripening can be induced …
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Calibration of sonographic gel probe covers for in-vivo mechanical testing
Cervical insufficiency is a condition in pregnancy in which the cervix asymptomatically dilates in the absence of uterine contractions, resulting in a spontaneous preterm delivery. The condition is often misdiagnosed and presents a significant challenge for the clinical community. In order to …
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Biospectroscopy investigations Into cervical cytology
Local treatment for cervical intra-epithelial neoplasia (CIN) involves the removal of the affected part of the tissue and is >95% effective in preventing re-invasive disease. However, removal of part of the cervix is linked to significant adverse sequelae, including preterm birth; with cone depth …
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Biomechanics of cervical function in pregnancy : case of cervical insufficiency
… to allow for the delivery of the fetus. Cervical insufficiency refers to a condition in which the cervix dilates asymptomatically and painlessly in the absence of contractions from the uterine smooth muscle and results in a spontaneous pregnancy loss between the second and third trimester …
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Estrogenic Effects of Genistein in Ovariectomized Gilts
… administration of a graded dose of genistein on tissues known to be estrogen sensitive. Thirty-four post-pubertal gilts were ovariectomized, and randomly assigned to one of six-treatment groups 15 days post-ovariectomy. Treatment groups received vehicle, estradiol (2 mg/day), or genistein (50, …
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Lamina-associated polypeptide 2 (LAP2) expression patterns in transformed and cancer cells
… elevated levels of LAP2α in cervical cancer patient material compared to normal. Altered expression of LAP2 may thus have significance in the development of certain cancers. The aim of this project was thus to independently confirm the up-regulation of LAP2α in …
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The impact of vaccination on adenocarcinoma associated with non-vaccine type HPV : a mathematical model with two HPV types
… human papilloma virus (HPV) is the main cause of cervical cancer in women and HPV is the most common sexually transmitted infection. To prevent women from developing cervical cancer there are two methods in use, the primary method being vaccination against HPV and the secondary being screening. …
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The molecular pathways mediating the role of cyclooxygenase enzymes and prostaglandins in cervical neoplasias
Cervical Carcinoma is one of the leading causes of cancer-related death in women. The prevalence of this disease is particularly high in South Africa, occurring on average, in 60 out of every 100 000 women. Previous studies have demonstrated over-expression of cyclooxygenase-2 enzyme and enhanced …
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Evaluating the role of PLGF and VEGFR-1/ Flt-1 in the development of cervical intraepithelial neoplasia and invasive cervical carcinoma in the background of HIV infection in women living in South Africa
Cervical cancer remains a major public health challenge in sub-Saharan Africa, where high-risk human papillomavirus (hr-HPV) infection and HIV co-morbidity drive elevated incidence and mortality (Kelly et al., 2022). While persistent hr-HPV infection is the primary etiological factor, the molecular …