Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Cervical carcinogenesis"”.
-
Factors Promoting Human Papillomavirus Mediated Cervical Carcinogenesis
… papillomavirus (HPV) is the causative agent of cervical cancer. Integration of the HPV genome into the host genome is a key event in cervical carcinogenesis, with oxidative stress (OS) likely playing a major role in promoting DNA damage, and subsequently, integration. In our current study, we …
-
Mechanisms of human papillomavirus and host gene transcriptional deregulation in cervical carcinogenesis
Cervical malignancy is the fourth most common cause of cancer-related mortality in women worldwide; infection with high-risk human papillomavirus (HRHPV) is responsible for over 500,000 cases of cervical carcinoma each year, approximately 90% of which are squamous cell carcinomas (SCCs). Over half …
-
Cell-Type-Specific Requirement of Progestereone Receptor for Suppression of Cell Proliferation and Carcinogenesis in the Cervix
Cervical cancer is the third most leading cause of cancer deaths in women worldwide. Persistent infection with high–risk human papillomaviruses (HPVs) is causally associated with cervical cancer. High–risk HPV E6 and E7 oncoproteins promote cell proliferation by inactivating p53 and pRb cellular …
-
Influence of molecular and genetic factors of the organism΄s antioxidative system on cervical carcinogenesis and the role of these factors in treatment of locally advanced cervical cancer /
Incidence of cervical cancer in Lithuania is one of the largest in Europe. Approximately in 50% of the cases locally advanced cervical cancer is diagnosed, despite screening programme. In order to more effectively diagnose and treat this disease, it is necessary to deepen knowledge about cervical …
-
Cervical Cancer at the Crossroads. An historical ontology of evidence in cervical cancer prevention
… of complex changes in the practices of cervical cancer prevention. Since the post-war period, women throughout most western countries have undergone cytology-based screening to detect and treat cellular changes before they turn to cancer. Over the past decades, the recognition of the …
-
Cytokine Dysregulation Promotes HPV Persistence
… (HPV) is the causative agent in almost all cervical cancers. Most HPV infections are resolved by the cell-mediated immune response of the host. However, in a small subset of individuals exposed to genital HPV, infection persists and can progress to cervical carcinoma. The inability to …
-
Human papillomaviruses in skin cancer and cervical cancer
… human papillomavirus (HPV) and development of cervical cancer is well established. In contrast, the significance of infections with cutaneous HPV for development of non-melanoma skin cancer (NMSC) is not well understood. We have evaluated whether seropositivity to cutaneous HPV is a marker for …
-
Suppression of Cervical Cancer by the Progesterone Receptor Signaling
Cervical cancer is the fourth-most common cancer in woman and fourth leading cause of cancer death worldwide. The majority of cervical cancer is associated with high-risk human papillomaviruses (HPVs). Their tumorigenic potential stems mainly from viral oncoproteins E6 and E7, which are best known …
-
Computational Analysis of Transcriptional Regulation
… and transcription using the W12 model for early cervical carcinogenesis with a novel Chromosome Conformation Capture (3C) method that specifically enriches for interactions involving viral integrants. Integration occurs without disrupting host 3D chromatin structure but alters the expression of …
-
Evaluating the role of PLGF and VEGFR-1/ Flt-1 in the development of cervical intraepithelial neoplasia and invasive cervical carcinoma in the background of HIV infection in women living in South Africa
Cervical cancer remains a major public health challenge in sub-Saharan Africa, where high-risk human papillomavirus (hr-HPV) infection and HIV co-morbidity drive elevated incidence and mortality (Kelly et al., 2022). While persistent hr-HPV infection is the primary etiological factor, the molecular …