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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Ceruloplasmin"”.
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Human ceruloplasmin gene and cDNA
Ceruloplasmin is a 132Kda serum protein found in all vetebrates. The protein ismulti-functional. Functions include copper transport, serum and tissue anti-oxidant and anti-coagulation modulation. The cDNA of ceruloplasmin sharehomology with the cDNAs of factors V and VIII of the blood coagulation …
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Copper status in multiple trauma patients: measurement of copper balance, serum copper and ceruloplasmin
… Twenty-four hour copper losses, serum copper and ceruloplasmin were measured in 11 MTP with Injury Severity Scores (ISS) >12 at 24-48 hours post admission. Collections of biological fluids (urine, nasogastric, chest tube, drains, stools) were analyzed for copper using atomic absorption …
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Novel risk factors for atrial fibrillation in an urban population
… (ISPs) and genotyping of polymorphisms in the ceruloplasmin gene (CP). Red blood cells distribution width (RDW) was measured in participants of Paper III. Carotid intima-media thickness (IMT) was measured in participants of Paper IV. All subjects were without history of AF, myocardial …
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Iron and copper interactions in humans: models and mechanisms.
… was used as a tool to examine how Fe and ceruloplasmin were inter-related in humans. Fifty three pregnant women, aged from 19 to 39 years (29.8 ± 1.08 years), referred for antenatal care were recruited at the Aberdeen antenatal clinic (Aberdeen Maternity Hospital, U.K.). Venous blood …
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Studies on the role of hephaestin and transferrin in iron transport
… generation of harmful hydroxyl-free radicals. Ceruloplasmin is the major multicopper ferroxidase in blood; however, hephaestin, a membrane-bound ceruloplasmin homolog, has been implicated in the export of iron from duodenal enterocytes into blood. These ferroxidases supply transferrin, the …
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Function of multicopper oxidases adsorbed on gold nanoparticles /
… As multicopper oxidases, laccases and human ceruloplasmin are used. The enzymes have been employed in electrochemical systems consisting of gold electrodes covered by gold nanoparticles and enzymes. For the first time direct electron transfer between gold nanoparticle and active centre of …
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Misregulation of Iron Handling Proteins in Excitotoxic Brain Injury
… of the iron transporters, ferroportin-1 and ceruloplasmin was also observed after kainate injection. The misregulation of iron handling proteins would lead to abnormally high iron accumulation in kainate lesioned hippocampus, which generate reactive oxidative stress and further contribute to …
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Protein polymorphism in northern populations of field mice (Apodemus sylvaticus L.)
… Protein: Serum pre-albumins, albumin and ceruloplasmin are monomorphic, whilst post-albumin and transferring may be polymorphic. R-cell proteins A and B are polymorphic. Other tissue proteins were found to be uniform, except for a cathodally migrating protein fraction in striated muscle. …
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SERUM AMYLOID A IN RUMINANTS: DIAGNOSTIC VALUE AND FOOD CONTAMINATION ASSESSMENT
… namely Serum amyloid A, Haptoglobin, Ceruloplasmin, α1-acid glycoprotein and Lipolysaccaride Binding Protein were sequenced for the first time, and two of them were quantified. In the second part of the thesis, we purified amyloid fibrils from amyloidosis-affected cows, and added …
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Elucidating the role of Mitoferrin (Mfrn), Iron Regulatory Proteins (IRP1 and IRP2) and Hephaestin (Heph) in Iron Metabolism by tagSNP and Protein-Protein Interaction (PPI) analysis
… identification of a potential ferroxidase. Ceruloplasmin (Cp) was used as a postive control. Non-denaturing gel eletrophoresis of the K562, MDA-MB-231 and PNT2-C2 cell fractions confirmed the presence of the extra band establishing the ubiquitous nature of the band. Mass spectrometry …
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Copper supplementation and monocyte function in growing beef calves
… 126. Calves supplemented with Cu had increased ceruloplasmin activity on d 84, 126, and 150 as compared to controls. Hepatic Cu measured on d 150 was decreased in controls compared to Cu-supplemented calves. Monocyte cell number and function from CuLy-supplemented calves showed increased …
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The effect of a dietary phase 2 protein inducer on inflammatory parameters in blood and liver of spontaneously hypertensive stroke prone rats
… an increase in plasma albumin and a decrease in ceruloplasmin), 4. Activity of phase 2 enzymes (increased phase 2 enzyme induction results in higher activities of liver quinone reductase (QR), glutathione-S-transferase (GST) and glutathione reductase (GR)). My experimental results demonstrated …
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Topographical Differences in Stress Vulnerability in Experimental Parkinson's Disease
… levels of the antioxidants glutathione and ceruloplasmin, and loss of glutathione synthesis rendered neocortex as vulnerable to proteotoxicity as allocortex. Consistent with these observations, allocortex was protected against proteotoxicity by facilitating glutathione synthesis with …
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Stress and the coronary-prone behavior pattern in working women
… population such as increased corticosteroids, ceruloplasmin, and proteins along with decreased levels of glucose, ascorbic acid, and oxidation- reduction protein.
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Iron-induced Complement Dysregulation in the Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration
… hypothesis comes from mice lacking ferroxidases Ceruloplasmin (Cp) and Hephaestin (Heph), which have a primary genetic defect in iron homeostasis. These mice develop some AMD-like morphological features and a telling molecular feature: activated complement component 3 (C3) fragment deposition at …
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Effects of a sustained-release copper bolus on growth and reproductive traits of beef bulls
… venipuncture to determine serum Cu and plasma ceruloplasmin (Cp) concentrations. Breeding soundness examinations (B S E) were conducted on all bulls on d 140 and 185 in experiment 1 and d 168 in experiment 2. Body weight and SC were not affected by treatment in either experiment (P > .05). …
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The Effects of Excess Dietary Sulfur Using Supplemental Sodium Sulfate on Beef Steer, Heifer, and Progeny Productive and Physiological Responses
… plasma and liver Cu concentrations and plasma ceruloplasmin activity (S main effect, P ≤ 0.07). Progeny liver Cu concentrations were similar among treatments and indicative of adequate liver Cu status in cattle, which was in contrast to maternal Cu indices. </p>
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Dietary Selenium in Cultured Hybrid Striped Bass
… various biomarkers of fish health (lysozyme, ceruloplasmin and glutathione peroxidase (GSH-Px) activities), were examined to determine whether dietary Se supplementation had a positive impact upon fish immunocompetence. Moreover, the effect of vaccination was also examined using lysozyme and …
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Pharmacokinetics and pharmacodynamics of non-steroidal anti-inflammatory drugs in birds
… indices, such as plasma corticosterone and ceruloplasmin levels, serum thromboxane B2 and zinc levels were also monitored during the experiment. In a separate experiment, food and water consumption and other behavioural parameters were studied. In the first experiment, a dose dependent …
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