Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 110 for “"Cerebrospinal fluid (CSF)"”.
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Describing the immune cell profile of ventricular cerebrospinal fluid (CSF) in paediatric central nervous system (CNS) infections
… this is the analysis of infected ventricular cerebrospinal fluid (CSF), but there is often a paucity of cells in CSF samples, especially in conditions like tuberculous meningitis (TBM), and these undergo rapid immune cell death after sampling. Consequently, the cell populations in CSF are not …
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Studies of Low Levels of Anti-Pseudorabies Antibody in Swine
… even lower antibody levels can be present in the cerebrospinal fluid (CSF). Study of low antibody and its causes was initiated to elucidate new features of PR pathogenesis.
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Central control of food intake in the domestic fowl
… to determine if factors exist in the blood or cerebrospinal fluid (CSF) of the domestic fowl that act upon the central nervous system to control food intake. Plasma collected from free-feeding and 24-hour fasted leghorn cockerels was lyophilized, reconstituted to 2, 4, or 5 times the original …
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Brain-derived Extracellular vesicles as biomarkers of Parkinson’s disease
… biomarkers of PD have concentrated on analyzing cerebrospinal fluid (CSF). Although CSF is ideal due to its intimate relationship with cells of the central nervous system, obtaining it is relatively invasive. In contrast, brain-derived extracellular vesicles (EVs) are found to be in substantial …
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Cerebrospinal fluid flow quantification in the brain using magnetic resonance imaging
… is a severe brain condition in which cerebrospinal fluid (CSF) cannot properly drain into the spinal cord, resulting in a buildup of pressure. To relieve this pressure, a shunt is placed in the brain that drains the CSF. However, the failure rate of these shunts is high, requiring …
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Association between CSF Biomarkers and Performance on Neuropsychological Test in Patients with Mild Cognitive Impairment
… (T-tau) and phosphorylated tau (P-Tau) in cerebrospinal fluid (CSF). To increase prognostic specificity of MCI to AD, studies have linked findings in CSF to neuropsychological profiles in MCI. The aim of this research was to find out if there is an association between critical biomarkers, …
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Techniques for the Collection and Assay of Sleep Promotion Factor in Exercised and Sleep Deprived Dogs
… rested animals after a ventricular infusion of cerebrospinal fluid (CSF) from sleep deprived animals. According to the humoral theory of sleep, this is caused by the presentation of some sleep promoting substance (factor S) which depresses the brain. The somnolence produced is accompanied by an …
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Assessing Blood-Based Laboratory Diagnostics for Alzheimers’s Disease: A Systems Approach
… (AD). Traditional diagnostic methods, including cerebrospinal fluid (CSF) testing and positron electron tomography (PET) brain imaging, are invasive, costly, and inaccessible to many. Blood-based tests offer a less invasive and more cost-effective alternative, yet they remain underutilized in …
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Harnessing Cancer Omics to Inform Precision Oncology
… cell RNA sequencing (scRNA-seq) of patients’ cerebrospinal fluid (CSF) samples. We profiled functional proteomics from kidney tumor samples using reverse phase protein array (RPPA) and formulated an MTOR score that improves prognosis prediction of recurrent risk given Leibovich risk scoring. …
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The role of the astrocytic marker S100B in HIV-associated neurocognitive disorders
… (ART) was initiated. The S100β levels in the cerebrospinal fluid (CSF) of forty-six participants with HIV, but not yet on antiretroviral therapy, was quantified using an enzyme-linked immunoassay (ELISA). A battery of cognitive tests was performed and the global deficit score (GDS) was …
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Predictive ability of cerebrospinal fluid biomarkers in diagnosing and evaluating Parkinson's disease
… of this thesis was to determine whether or not cerebrospinal fluid (CSF) biomarker data could predict incidence of Parkinson's with a high degree of accuracy and differentiate between patients with varying levels of severity. We used various supervised machine learning algorithms on the …
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Evaluation of Neurofilament Light Chain as a Biomarker in Dogs with Structural and Idiopathic Epilepsy
… contribute a total of 58 samples (52 serum and 6 cerebrospinal fluid (CSF)). Dogs diagnosed with structural epilepsy received magnetic resonance imaging (MRI). Dogs were grouped into acute seizures when they had a generalized seizure within the last 7 days and chronic seizures when they had no …
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Proteomic-based Signature of Brain-related Proteins as Novel Candidate Biomarkers for Alzheimer’s Disease Diagnosis
… tangles. Brain pathology is reflected in cerebrospinal fluid (CSF) where core biomarkers amyloid beta 1-42, total tau, and phosphorylated tau protein levels are changed relative to cognitively normal elderly. There is a need for novel disease-specific biomarkers that will capture disease …
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Using B Cell Characteristics as Predictors of Multiple Sclerosis in Clinically Isolated Syndrome Patients
… CD19\super +\nosupersub B cells in their cerebrospinal fluid (CSF) compared to peripheral B cells from healthy donors (HCPB) or CSF B cells from patients with neurological diseases not related to MS. However, VH4 bias was a moderate predictor for conversion to MS. Nevertheless, detailed …
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The Role of Perivascular Fibrosis In Post-Stroke Glymphatic Impairment and Cerebral Amyloid Angiopathy
… are transported by the pulsatile flow of cerebrospinal fluid (CSF) along perivascular drainage pathways. Ischemic stroke may disrupt this process, leading to a perivascular build-up of Aβ, termed cerebral amyloid angiopathy (CAA). I hypothesize that an abnormal pattern of extracellular …
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Characterization of Cre Mouse Models to Target CNS Barriers for Generating Conditional Knockouts of ABC Transporters
… both possess a blood to brain and a blood to cerebrospinal fluid (CSF) barrier. The blood-brain barrier (BBB) and blood-CSF barrier (BCSFB) regulate the passage of many molecules to maintain and protect these sensitive organs from harmful xenobiotics (i.e. drugs, pollutants, etc.) or …
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Experimental study of bubble rupture during shock-fluid interaction
… is hypothesized that cavitation can occur in the cerebrospinal fluid (CSF) layer, brain interstitial fluid, and possibly also in the cerebral blood. In this thesis, it is tested that if a bubble is present, it collapses when a shock wave passes through it. The effect of shock waves on cavitation …
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I. THE DEVELOPMENT OF TWO ASSAYS, EMPLOYING ENZYMES AS REAGENTS, FOR THE DETERMINATION OF LECITHIN AND TOTAL CHOLINE-CONTAINING PHOSPHOLIPIDS IN AMNIOTIC FLUID. II. A STUDY OF CO-SUBSTRATES FOR PEROXIDASE COUPLED REACTIONS. III. A STUDY OF THE APPLICABILITY OF A BIURET PROCEDURE AND TWO DYE-BINDING PROCEDURES TO TOTAL PROTEIN AND ALBUMIN DETERMINATIONS IN CEREBROSPINAL FLUID.
… choline-containing phospholipids in amniotic fluid, which employ enzymes as reagents have been developed, optimized and carried through the initial clinical trials. Unlike previous procedures for the prediction of respiratory distress syndrome, both assays are relatively quick, simple, …
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Tests, Tests, and More Tests: A New Era for Dementia Diagnosis
Cerebrospinal fluid: CSF) proteins correlate with pathological changes that are hallmarks of Alzheimer’s disease: AD). CSF biomarkers have been used in research settings to predict AD diagnosis and rate of cognitive decline, however their use in clinical settings is limited. Given their potential …
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