Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Cerebral organoid"”.
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Characterization of A Novel Oncogenic Mirna Inhibitor In Cancer Therapy
… vitro</em>. This effect is also shown in a cerebral organoid model. Using a multidisciplinary approach, this study identifies a relationship between oncogenic miR-10b and the dysregulation of the PI3K/AKT pathway in cancer, along with putting forth a compound that can mitigate these effects. …
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Traumatic Injury-Induced Cell Responses in Human Cortical Organoids
… Here, I developed a 3D human stem cell-derived cerebral organoid slice culture that recapitulates cortical cell diversity and mimics aspects of human traumatic brain injury. This accessible multicellular model allows more precise observations on human CNS-specific propagation of cellular …
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Scaling up 3D imaging, analysis, and culture of complex brain models
… intact mouse beams, marmoset bi am samples, and cerebral organoids The mouse brain pipeline allows region-based statistical analysis of protein expression and cell counts An efficient single-cell non-rigid coregistration algorithm for multiplexed volumetric fluorescence imaging based on matching …
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Fabrication of Designable and Suspended Microfibres via Low Voltage Electrospinning Patterning towards Replicating Extracellular Matrix Cues for Tissue Assembly
… was investigated to improve the efficiency of cerebral organoid assembly. Pursuing these applications led to further refinement of the fibre fabrication technique and the development of targeted cell seeding strategies on suspended fibre structures. Glioblastoma cell aggregates were cultured on …
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Modelling Prenatal Hypoxia As A Risk Factor For Schizophrenia Vulnerability In Patient-Derived Cerebral Organoids
… unclear. Our laboratory has developed human cerebral organoids using induced pluripotent stem cells (iPSCs) derived from healthy control or SCZ patient cell lines to address these questions. This creates a platform that allows for the investigation into the pathophysiology of SCZ and hypoxia …
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Astrocytic Sonic Hedgehog signalling in development and disease
… modified rodent models, alongside human-derived cerebral organoids. This research seeks to elucidate the mechanisms by which Shh signalling instructs astrocyte function, heterogeneity, and their contribution to the broader neural environment. My overarching hypothesis is Shh signalling …