Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"Cerebral metabolism"”.
-
Cerebral metabolism of hypoxic fetal sheep investigated by NMR Spectroscopy
Contains fulltext : 146685.pdf (Publisher’s version ) (Open Access)
-
Measurement of Cerebral Metabolism and Vascular Function with Magnetic Resonance Imaging
The brain relies on oxidative metabolism to function properly. Cerebral metabolic rate of oxygen (CMRO2) is thus an important marker for brain health. Existing techniques for quantification of CMRO2 with positron emission tomography (PET) or magnetic resonance imaging (MRI) involve special …
-
Imaging and Measuring Cerebral Metabolism in the Healthy Brain and Changes Following Inflammation
Metabolism is a key process to the function and survival of all living organisms. The role of metabolism is key in many pathologies, and presents a prime opportunity to both understand and treat disease in new ways. In particular, lactate is a molecule which has been known and studied for many …
-
Hypothermia and rewarming after cardiac arrest. Dynamics in cerebral blood flow, cerebral metabolism and inflammation
Contains fulltext : 139518.pdf (Publisher’s version ) (Open Access)
-
Cerebral Metabolic and Neuropsychological Outcomes Following Mild Traumatic Brain Injury
… assessment to determine if prolonged cerebral metabolic and cognitive alterations occur in individuals with persistent neurocognitive deficits following a mild TBI (mTBI). The current study evaluated the potential interactions between cerebral metabolism and neuropsychological …
-
Interrogating and potentiating energy metabolism in the human brain after traumatic brain injury
… injury (TBI) includes perturbations to energy metabolism. Improving our understanding of cerebral energy metabolism will lead to strategies that improve clinical outcomes. For the studies in my thesis I used microdialysis to deliver carbon-13 labelled substrates to the human brain. I combined …
-
MRI based cerebral oxygenation measures in humans : technical development for use across lifespan
MRI based cerebral oxygenation measures could enable brain-centered clinical care and improve understanding of brain energy use throughout human development. We made technical improvements to two MR oxygenation imaging techniques, and explored the concordance between various methods to quantify the …
-
Brain states and circuit mechanisms underlying sleep and general anesthesia
… local cortical dynamics consistent with impaired cerebral metabolism. Taken together, these results identify a set of neural dynamics associated with unconscious states, and demonstrate specific mechanisms for how they disrupt brain function. These findings provide new insight into the …
-
Factors Affecting Focal Cerebral Ischemic Infarction: Inferences from Experimental Modelling in Macaques and Murines
… same manner as in humans, such as: injury size, cerebral metabolism, cerebral vascularity and perfusion, and thresholds of cell death. These confounding variables, and various animal models of stroke, are discussed in the background of the thesis. As such, the internal validity of animal models, …
-
Heading Disorientation in Amnestic Mild Cognitive Impairment is Correlated with Hypometabolism in the Posterior Cingulate Cortex
… to extract the regions whose changes in regional cerebral metabolism correlated significantly with part A and B of the CPT with adjustment of age and sex of patients. RESULTS: Controlling for age, sex, and education years, the K-MMSE score and CPT B score was significantly lower in the aMCI group …
-
Contusion Progression in Traumatic Brain Injury
Cerebral contusions that result from brain trauma have the propensity to enlarge over the days following injury, including extension of the haemorrhage core and swelling of the surrounding peri-contusional brain. This secondary injury increases the likelihood of death and severe disabil- ity, and …
-
Investigation of BACE1 as a stress-induced regulator of neuronal metabolism
… and oxidative stress events as well as reduced cerebral metabolism thought to occur early on in disease progression.<br/><br/>Evidence from rare, familial AD cases suggests a causative role for A in AD pathogenesis. For this reason, the enzyme beta-site amyloid precursor protein (APP) cleaving …
-
Influence of Whole Body Exposure of 914 MHz Radiofrequency Identification on Endocrine system
… thyroid hormone system and melatonin, and cerebral metabolism, especially glucose metabolism. For these animal trials, a reverberation chamber was used as a whole-body exposure system. RFID exposure trial was performed during the day for the studies except for a study regarding the pineal …
-
Hypoxia and vascular nitric oxide bioavailability: Hypoximplications for the pathophysiology of high-altitude illness
… of acute mountain sickness (AMS), high-altitude cerebral oedema (HACE) and high-altitude pulmonary oedema (HAPE), though data to date remains scarce. Therefore, there is a clear need for further work to address the role of NO in the pathogenesis of high-altitude illness.Aims: There were two …
-
Method Development of 13C, 1H and 31P Magnetic Resonance Spectroscopy for use in Traumatic Brain Injury
… its ability to directly measure in vivo rates of cerebral metabolism non-invasively. In this thesis the 13C-labelled substrate [2-13C]glucose was used for infusion due to its reduced technical demands. To date [2-13C]glucose infusion research has mainly focused on acquisition based methodological …
-
NNeMo (Neonatal NeuroMonitor) - a hybrid optical system to characterize perfusion and metabolism in the newborn brain
… a further 5-10% develop major disorders such as cerebral palsy. The likelihood of injury increases with a shorter gestational period and/or a lower birthweight. Intraventricular hemorrhaging (IVH) occurs in 20-25% of VLBW infants, characterized by bleeding in the germinal matrix and surrounding …
-
Behavioural, genetic and epigenetic determinants of white matter pathology in a new mouse model of chronic cerebral hypoperfusion
… this hypothesis, cerebrovascular (e.g. chronic cerebral hypoperfusion) and molecular (e.g. APOE, epigenetics) factors might contribute to age-related white matter pathology and cognitive decline. To test this, I used a new mouse model of chronic cerebral hypoperfusion and examined the following …
-
ΜΕΛΕΤΗ ΤΟΥ ΤΟΠΙΚΟΥ ΕΓΚΕΦΑΛΙΚΟΥ ΜΕΤΑΒΟΛΙΣΜΟΥ ΤΗΣ ΓΛΥΚΟΖΗΣ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΕΣΤΙΑΚΗ ΕΠΙΛΗΨΙΑ ΚΑΙ ΣΥΣΧΕΤΙΣΜΟΣ ΜΕ ΚΛΙΝΙΚΑ ΚΑΙ ΕΡΓΑΣΤΗΡΙΑΚΑ ΔΕΔΟΜΕΝΑ
ΤΡΙΑΝΤΑ ΕΞΗ ΑΣΘΕΝΕΙΣ ΜΕ ΕΣΤΙΑΚΗ ΕΠΙΛΗΨΙΑ ΕΜΕΛΕΤΗΘΗΚΑΝ ΩΣ ΠΡΟΣ ΤΟΝ ΤΟΠΙΚΟ ΕΓΚΕΦΑΛΙΚΟ ΜΕΤΑΒΟΛΙΣΜΟ ΤΗΣ ΓΛΥΚΟΖΗΣ ΜΕ ΤΗΝ ΜΕΘΟΔΟ ΤΗΣ ΤΟΜΟΓΡΑΦΙΑΣ ΕΚΠΟΜΠΗΣ ΠΟΖΙΤΡΟΝΙΩΝ. ΟΙ ΑΣΘΕΝΕΙΣ ΕΙΧΑΝ ΕΠΙΣΗΣ ΠΛΗΡΗ ΕΛΕΓΧΟ ΚΛΙΝΙΚΟ, ΗΛΕΚΤΡΟΕΓΚΕΦΑΛΟΓΡΑΦΙΚΟ ΚΑΙ ΑΚΤΙΝΟΛΟΓΙΚΟ. ΟΙ ΑΣΘΕΝΕΙΣ ΕΠΑΣΧΑΝ ΑΠΟ ΑΝΘΙΣΤΑΜΕΝΗ ΣΤΗΝ …
-
MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… an important role in the development of the cerebral lesions [6]. This inflammatory reaction involves activation of resident cells (mainly microglia), infiltration and accumulation of various inflammatory cells (including neutrophils, leukocytes, monocytes, macrophages), and production of …