Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"Cerebral malaria"”.
-
murine cerebral malaria: aspects of pathogenesis and protection
Contains fulltext : 18672.pdf (Publisher’s version ) (Open Access)
-
Intracranial hypertension in Kenyan children with cerebral malaria
Cerebral malaria is a common encephalopathy in African children, but the cause of death and neurological sequelae are unknown. This dissertation examines the hypothesis that raised intracranial pressure (ICP) is a determinant of poor outcome in Kenyan children with cerebral malaria. The opening …
-
Malarial retinopathy and neurovascular injury in paediatric cerebral malaria
… potential markers of brain disease. Paediatric cerebral malaria is a severe neurological complication of infection with the parasite Plasmodium falciparum, which is responsible for death and disability in a significant number of children in sub-Saharan Africa. As with many neurological diseases, …
-
Identification of Host and Parasite Factors Mediating the Pathogenesis of Severe and Cerebral Malaria
Severe manifestations of malaria, including cerebral malaria (CM) and respiratory distress, result in approximately three million deaths annually worldwide. Currently, relatively little is known about severe disease pathogenesis. The development and outcome of severe malaria is determined by …
-
Corpus callosum morphology in retinopathy-positive and retinopathy-negative Malawian children diagnosed with cerebral malaria
… and retinopathy-negative pediatric survivors of cerebral malaria (CM). Participants were 20 children who were admitted to the Queen Elizabeth Central Hospital in Blantyre, Malawi, and satisfied the clinical case definition of CM. There were two groups: retinopathy-positive CM (n = 16) and …
-
Behavioral changes in children in Malawi, after recovering from cerebral malaria and treatment acceptability among Malawian parents
Cerebral malaria is a life-threatening disease that affects many children in sub-Saharan Africa. Research has shown that children that survive this disease are often left with neurological disabilities after their recovery, for example behavioral changes similar to ADHD. However, diagnosis and …
-
Hyperinflammatory Experimental Cerebral Malaria: Coagulation and Glial Cell Activation in Plasmodium chabaudi Infection of IL-10-deficient Mice
Cerebral malaria is one of the most severe complications of Plasmodium falciparum infection and occurs mostly in young African children. This syndrome results from a combination of high levels of parasitemia and inflammation. While mutations in inflammatory cytokine genes and the levels of …
-
A study of the immune response in murine experimental malaria, with special reference to the effects of South African medicinal plants, artesunate and chloroquine
… (TNF and IFN-y) in a murine experimental malaria model for cerebral malaria is reported in this thesis. Wild type and receptor knockout mice (IFN-y deficient mice (IFN-l") and TNF-a/fr1- double deficient) were infected with Plasmodium berghei ANKA {PbA). PbA induced fatal cerebral malaria …
-
Host Response to Plasmodium Infection: Implications for Pathogenesis and Management of Severe Malaria
Cerebral malaria (CM), caused by
-
A Comparative Study of the Pathology and Pathophysiology of Severe Malaria in a Non-Human Primate Model
… the world, a dwindling arsenal of anti-malarials and a predilection for use of less than ideal murine models, the need for effective, applicable and established animal models through which to understand severe malarial disease and test potential treatments is becoming increasingly …
-
A study to determine the morbidity and mortality patterns of malaria in children in a very low transmission setting
… Despite several strides made to control malaria in Zambia, it still is endemic in many parts of the country and remains one of the leading causes of morbidity and mortality. Its epidemiology is characterised by varying transmission intensities which may bring about change in the patterns …
-
A study to determine the morbidity and mortality patterns of malaria in children in a very low transmission setting
… Despite several strides made to control malaria in Zambia, it still is endemic in many parts of the country and remains one of the leading causes of morbidity and mortality. Its epidemiology is characterised by varying transmission intensities which may bring about change in the patterns …
-
Host Inflammatory Pathways in Malaria Infection: Potential Therapeutic Targets and Biomarkers of Disease Severity
Severe malaria infections cause almost 1 million deaths annually, mostly among non-immune African children. The pathogenesis of severe malaria is poorly understood. It is increasingly appreciated that while host innate immune responses such as inflammation and phagocytosis are critical for control …
-
Neurocognitive impairment following central nervous system infections in Kenyan children as detected by event related potentials
… in sub-Saharan Africa, namely falciparum malaria, acute bacterial meningitis (ABM) and human immune-deficiency virus (HIV). Four groups of children were recruited: children previously admitted with severe falciparum malaria (n= 50), or acute bacterial meningitis (n = 65), or mY-infected …
-
Identifying parasite virulence factors and host genetic and immunologic factors that contribute to severe malarial outcomes in Ugandan children
Cerebral malaria (CM) and severe malarial anemia (SMA) remain drivers of morbidity and mortality due to Plasmodium falciparum infection in children in Sub-Saharan Africa. There are currently no adjunctive therapies for severe malaria (SM), suggesting that we need a better understanding of both host …
-
An investigation of the relationship between malaria and red-cell polymorphisms in Madang, Papua New Guinea
… a heterozygote survival advantage against malaria. This “malaria hypothesis” formed the basis for this programme of research. Between 1993 and 2006, | conducted a series of comprehensive and detailed studies of the relationships between malaria and the common red-cell variants …
-
Discovery of Alternative Artemisinin Binding Sites in Plasmodium falciparum ATPase-6
Malaria is a fatal yet preventable and treatable disease. It is commonly spread through the bite of an infected Anopheles mosquito. Malaria parasites belong to the Plasmodium genus and can be caused by the falciparum, malariae, ovale, vivax, and knowlesi species. Artemisinin is an endoperoxide …
-
Identification of malaria parasite-infected red blood cell aptamers by inertial microfluidics SELEX
Malaria kills over 500,000 people annually, the majority of whom are children under five years old in sub-Saharan Africa. This disease is caused by several parasite species, of which Plasmodium falciparum is associated with the highest mortality. The clinical manifestations of malaria are …
Page 1 of 2