Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Cerebral ischemia"”.
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Astrocyte metabolism following focal cerebral ischemia
… of either the response of astrocytes to cerebral ischemia or the extent to which these cells can recover function if blood flow is restored. The main aim of the project was to assess key metabolic properties in astrocytes during early reperfusion following unilateral occlusion of the …
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Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… toxicity, exhibited anti-apoptotic properties on cerebral ischemia injury. HNG reduced infarct volume after ischemia/reperfusion injury with pre-treatment or post-treatment (i.c.v. and i.p.) in a middle cerebral artery occlusion model in mice and decreased neurological deficits induced by …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… an important role in the development of the cerebral lesions [6]. This inflammatory reaction involves activation of resident cells (mainly microglia), infiltration and accumulation of various inflammatory cells (including neutrophils, leukocytes, monocytes, macrophages), and production of …
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Development of SiRNA Incorporated Surface Modified Polymeric Nanoparticle for the Potential Treatment of Global Cerebral Ischemia
Global cerebral ischemia is a cerebrovascular disease caused by cardiac arrest or cardiac surgery. Chronic and excessive neuroinflammation is a major contributor to cell death in the pathophysiology of global ischemia, likely having a detrimental effect on cognitive function. Bromodomain-containing …
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Predictive models of tissue outcome in acute human cerebral ischemia using diffusion and perfusion weighted MRI
… current therapeutic decisions for acute human cerebral ischemia are typically based on time of symptom onset, limiting the number of patients treated. Imaging, however, offers insight into the physiologic integrity of brain tissue that is not attainable with time of symptom onset alone. This …
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The role of dopamine in the striatal cell death produced by transient, global cerebral ischemia in rats
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Ρινική χορήγηση φαρμάκων στη διαχείριση της εγκεφαλικής ισχαιμίας / Nasal drug delivery in the management of cerebral ischemia
Η εγκεφαλική ισχαιμία είναι η κύρια αιτία θανάτου και μόνιμης αναπηρίας στον κόσμο. Είναι εξαιρετικά δύσκολη η αντιμετώπισή της λόγω της ταχείας εξέλιξης της νευρωνικής βλάβης και των περιορισμών των συμβατικών συστημάτων χορήγησης φαρμάκων. Η ρινική χορήγηση φαρμάκων χρησιμοποιείται για την …
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Assessing the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia
… statins in reducing stroke incidence, reducing cerebral ischemia in hypercholesterolemic patients, and preventing ischemic stroke. This paper aims to assess the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia. To achieve …
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Role of Cofilin, an Actin Cytoskeletal Protein, in Ischemic Conditions: Potential Therapeutic Target for Ischemic Stroke
Cerebral ischemia or stroke is a condition associated with decreased blood supply to brain leading to death of neurons. It is associated with a diverse cascade of responses involving both degenerative and regenerative mechanisms. Actin cytoskeleton changes play a key role in mediating these …
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Partielle Resistenz Chorea Huntington transgener Mäuse gegen globale cerebrale Ischämie
… HD transgenic mice are also resistant to global cerebral ischemia, installed by temporary bilateral occlusion of the common carotid arteries. Since the neurons of the hippocampus are known to show the lowest ischemic tolerances we especially investigated these neurons. We found out that HD …
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Evaluation der Umsetzung der Leitlinien der Deutschen Gesellschaft für Neurologie und der Deutschen Schlaganfallgesellschaft zur medikamentösen Sekundärprävention der zerebralen Ischämie durch Hausärzte
… for medicamentous secondary prevention of cerebral ischemia created by the German Stroke association and the German Association of Neurology by medical specialists working as general practitioners. Furthermore the study investigates reasons for deviation from the guidelines. For patients …
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Effect of Isoflurane Post-treatment on tPA-exaggerated Brain Injury in a Rat Ischemic Stroke Model
… post-conditioning is crucial for reducing ischemia-related injury. The aim of this study was to assess the effect of isoflurane post-treatment on intracranial hemorrhage and cerebral infarction after tPA treatment for transient cerebral ischemia. Cerebral ischemia was modeled in male …
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Paradoxe Hirnembolie : Nachweis von Risikofaktoren für Rezidive und Strategien zur Sekundärprophylaxe
… treatment is preferable to prevent recurrence of cerebral ischemia in patients with patent foramen ovale (PFO) as a suspected cause of stroke. Methods: During a prospective follow-up over a mean time of 52 ñ 32 months 124 patients (mean age 51 ñ 15 years) with cryptogenic cerebral ischemia and PFO …
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Einfluss der Anästhetika Sevofluran und Propofol auf den nekrotischen und den apoptotischen Zelltod nach inkompletter zerebraler Hemisphärenischämie und Reperfusion in der Ratte über einen Beobachtungszeitraum von 28 Tagen
… and apoptotic cell death after incomplete cerebral ischemia and reperfusion in the rat The present study investigates the effect of the anesthetic agents propofol and sevoflurane on irreversible cell damage (necrosis) and programmed cell death (apoptosis) for a time period of 28 days after …
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The Cross-Talk Between Neurons and Microglia Through Interleukin-4 After Ischemic Injury
… propose that this neuronal response to sublethal ischemia is designed to guide surrounding microglia/macrophages to a reparative and anti-inflammatory (M2) phenotype.</p> <p>The research included in this study is designed to establish the mechanisms that underlie neuronal production and secretion …
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An investigation of the neuroprotective properties of fenamate NSAIDs, against experimental model of ischemic stroke
… in understanding the underlying pathogenesis of cerebral ischemia support the involvement of multiple biochemical pathways in the development of the ischemic injury.</p> <p>The work reported in this thesis was undertaken to investigate the hypothesis that fenamate NSAIDs have neuroprotective …
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Perinatal hypoxic-ischemic brain injury – characterization, mechanisms and treatment
… such as Exendin-4. I showed that global cerebral ischemia was associated with a striking increase in concentration of adenosine triphosphate in the cerebrospinal fluid at 6 hours in near-term fetal sheep. Curiously, the increase in adenosine triphosphate occurred despite no change in the …
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The Total Synthesis of () 7-HDHA
… and related diseases (Alzheimers disease, cerebral ischemia, retina inflammation, etc.), the study of 7-HDHA in relation to PPARs has been hampered by the high cost and limited supply of 7-HDHA. The total synthesis of 7-HDHA was attempted using four different strategies, and finally …
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TREM1-Mediated Neuroinflammation is Critical to Global Ischemia-Induced Neurodegeneration and Cognitive Deficits.
Global cerebral ischemia occurs when blood flow to the entire brain is significantly reduced; this occurs most commonly following cardiac arrest. Following global ischemia, there is delayed and selective loss of neurons in the hippocampal CA1, a critical brain region for learning and memory, …
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